Abstract:
:High throughput methodologies have revealed the existence of an unexpectedly large number of long noncoding RNAs (lncRNAs). The unconventional role of lncRNAs in gene expression regulation and their broad implication in oncogenic and tumor suppressive pathways have introduced lncRNAs as novel biological tumor markers. The most prominent example of lncRNAs application in routine clinical practice is PCA3, a FDA-approved biomarker for prostate cancer. Regarding digestive system malignancies, the oncogenic HOTAIR is one of the most widely studied lncRNAs in the preclinical level and has already been identified as a potent prognostic marker for major malignancies of the gastrointestinal tract. Here, we provide an overview of recent findings regarding the emerging role of lncRNAs not only as key regulators of cancer initiation and progression in colon, stomach, pancreatic, liver, and esophageal cancers, but also as reliable tumor markers and therapeutic tools. lncRNAs can be easily, rapidly, and cost-effectively determined in tissues, serum, and gastric juice, making them highly versatile analytes. Taking also into consideration the largely unmet clinical need for early diagnosis and more accurate prognostic/predictive markers for gastrointestinal cancer patients, we comment upon the perspectives of lncRNAs as efficient molecular tools that could aid in the clinical management.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Kladi-Skandali A,Michaelidou K,Scorilas A,Mavridis Kdoi
10.1155/2015/319861subject
Has Abstractpub_date
2015-01-01 00:00:00pages
319861eissn
1687-6121issn
1687-630Xjournal_volume
2015pub_type
杂志文章,评审abstract::Background and Aim. EUS-guided intervention (EGI) for biliary therapy has been increasingly used in recent years. This report aims to describe the spectrum and experience of EUS-guided interventions in biliary diseases in a single-tertiary center. Methods. All patients with EGI were analyzed retrospectively by retriev...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/680753
更新日期:2012-01-01 00:00:00
abstract::Gastric ectopic pancreas is an uncommon developmental anomaly and its histological diagnosis is usually difficult by using a conventional biopsy forceps. In the literature, most cases of gastric ectopic pancreas were usually diagnosed by gross pattern during endoscopic examination or features of endoscopic ultrasound....
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/160601
更新日期:2014-01-01 00:00:00
abstract::Purpose. By examining the prescribing patterns and inappropriate use of acid suppressive therapy (AST) during hospitalization and at discharge we sought to identify the risk factors associated with such practices. Methods. In this retrospective observational study, inpatient records were reviewed from January 2011 to ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/1973086
更新日期:2016-01-01 00:00:00
abstract::The rapid rise of obesity and type 2 diabetes poses a global threat to healthcare and is a major cause of mortality and morbidity. Bariatric surgery has revolutionised the treatment of both these conditions but is invasive and associated with an increased risk of complications. The EndoBarrier is a device placed endos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/7823182
更新日期:2018-07-26 00:00:00
abstract::The technological progress within the range of methods of pancreas imaging and their more common accessibility selects a group of patients requiring a microscopic diagnosis. Percutaneous fine needle aspiration biopsy under the control of ultrasonography (PCFNA/USG) is the method commonly used in determining the charac...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/908963
更新日期:2012-01-01 00:00:00
abstract::Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of pati...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6126707
更新日期:2017-01-01 00:00:00
abstract::Background. Little data on directly comparing chemoradiotherapy with observation has yet been published in the setting of adjuvant therapy for resected gastric cancer who underwent D2 lymphadenectomy. The present indirect comparison aims to provide more evidence on comparing the two approaches. Methods. We conducted a...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/634929
更新日期:2013-01-01 00:00:00
abstract:Background:The aim of this study was to evaluate the risk of development of colorectal adenomas in patients with colorectal cancer (CRC) with and without colonic diverticulosis. Methods:We performed a retrospective cohort study that included patients with CRC between 2008 and 2011. All patients underwent preoperative ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/8901026
更新日期:2019-05-20 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy is the standard treatment for patients with locally advanced rectal cancer, although tumor responses vary widely; some patients may achieve a pathologic complete response rate (pCR) after chemoradiotherapy. Controversy exists with regard to the efficacy of different preoperativ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/1373092
更新日期:2017-01-01 00:00:00
abstract::Ovarian cancer peritoneal carcinomatosis requires a multimodal-treatment approach. Current treatment considerations are analyzed in this update and include the management of recurrent malignant ascites and the understanding of its pathophysiology, the role of peritoneal washing cytology in detecting peritoneal metasta...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/5284814
更新日期:2018-04-05 00:00:00
abstract:Background:Baicalin (BA) has been shown to have anti-inflammatory and antioxidant activity. Zinc is a nutrient element. Objective:This study is aimed at investigating the antichronic gastric ulcer activity of Zn-Baicalin complex (BA-Zn) and its related mechanisms in an acetic acid-induced gastric ulcer rat model. Res...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/1275486
更新日期:2018-10-28 00:00:00
abstract:Aim:This study aims to analyze factors possibly related to the prognosis of duodenal gastrointestinal stromal tumors (DGISTs). Methods:We collected and retrospectively analyzed clinical and pathological data of 62 patients with primary DGISTs. All the patients were hospitalized and received complete surgical resection...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/4812703
更新日期:2018-02-20 00:00:00
abstract::Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). In the innate immune system, Toll-like receptors (TLRs) are sensors that recognize bacterial and viral components such as lipopolysaccharide, bacterial DNA, and peptidoglycan. Recent ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2010/362847
更新日期:2010-01-01 00:00:00
abstract::Introduction. The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC). Material and Methods. The serum levels of study factors were measured in 73 patients with CRC and in 35 ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/146819
更新日期:2015-01-01 00:00:00
abstract::Caustic esophageal stricture (CES) in children still occurs frequently in developing countries. We aimed to evaluate the long-term outcomes of endoscopic balloon dilatation (EBD) in treating CES in children and the influencing factors associated with outcome. We retrospectively reviewed the data of all patients who ha...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/8352756
更新日期:2018-08-08 00:00:00
abstract::Background. Colon capsule endoscopy (CCE) is a diagnostic test with relatively rare usage. In this study, we aimed to evaluate both the optimal cleaning regimen for CCE and the diagnostic value of test in the study group. Methods. A total of 62 patients were enrolled in this study. In the first step, 3 different colon...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/2738208
更新日期:2016-01-01 00:00:00
abstract::Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/2676513
更新日期:2017-01-01 00:00:00
abstract::Introduction. Neoadjuvant chemoradiotherapy and total mesorectal excision are considered the standard treatment for locally advanced rectal cancer. Various studies have reported pathological downstaging and a complete pathological response rate of 15%-27% following neoadjuvant chemoradiotherapy which has translated in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/867841
更新日期:2014-01-01 00:00:00
abstract:Background:Tumor regression grade (TRG) is widely used in gastrointestinal carcinoma to evaluate pathological responses to neoadjuvant chemotherapy (NCT), but whether it is an independent prognostic factor is still controversial. The aim of this study is to investigate the value of TRG in locally advanced gastric adeno...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3435673
更新日期:2020-07-18 00:00:00
abstract::The aim of the present study was to examine the influence of gastrectomy (GX) on cortical and cancellous bones in rats. Twenty male Sprague-Dawley rats were randomized into the two groups of 10 animals each: a sham operation (control) group and a GX group. Seven weeks after surgery, the bone mineral content and densit...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,收录出版
doi:10.1155/2013/381616
更新日期:2013-01-01 00:00:00
abstract::Toll-like receptor (TLR) signaling pathways are strictly coordinated by several mechanisms to regulate adequate innate immune responses. Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS) family proteins, originally identified as negative-feedback regulators in cytokine signaling, are i...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2010/470468
更新日期:2010-01-01 00:00:00
abstract::Aims. The association between Helicobacter pylori (H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue. Methods. A total of 502 inpatients with Rome III confirmed IBS-D and known H. pylori status from 8 hos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/3059201
更新日期:2016-01-01 00:00:00
abstract::Background. An increasing resistance of Helicobacter pylori strains to antimicrobial agents is the serious therapeutic problem. The aim of this study was to compare the primary and secondary resistance of H. pylori strains isolated between 2006-2008 (data published) and 2009-2011 to clarithromycin and levofloxacin. Ma...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/418010
更新日期:2012-01-01 00:00:00
abstract::Background. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a preci...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5037254
更新日期:2016-01-01 00:00:00
abstract:Aim:Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocy...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5705782
更新日期:2019-06-10 00:00:00
abstract::Background/Aims. Hepatitis B virus (HBV) can form immune complexes which may result in various types of glomerulonephritis (GN). However, proteinuria can occur because of other kidney diseases besides HBV-related GN (HBV-GN). The aim of this study is to elucidate the causes of proteinuria and report on the clinical ou...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/126532
更新日期:2015-01-01 00:00:00
abstract:Objective:To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/5609623
更新日期:2020-09-30 00:00:00
abstract::Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5491465
更新日期:2016-01-01 00:00:00
abstract::Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology. Recently, mucosal healing has emerged as an important therapeutic endpoint in UC. Linked color imaging (LCI) is a novel endoscopic system that enhances the color differences of the gastrointestinal mucosa. Our previous study emphasi...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3108690
更新日期:2020-03-06 00:00:00
abstract::The objective of this study was to evaluate the possibility to undertake an ileocolic resection in complex Crohn's disease using a minimal open abdominal access using standard laparoscopic instruments. The incision was carried out over the previous McBurney scar, with a mean length of 6 cm. Seventy-two patients with c...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6019435
更新日期:2020-02-28 00:00:00