Abstract:
:Introduction. Neoadjuvant chemoradiotherapy and total mesorectal excision are considered the standard treatment for locally advanced rectal cancer. Various studies have reported pathological downstaging and a complete pathological response rate of 15%-27% following neoadjuvant chemoradiotherapy which has translated into improved survival. We endeavour to determine the clinical outcome of patients attaining a complete pathological tumor response following neoadjuvant chemoradiotherapy in the Indian setting where most of our patient population is younger and presents with aggressive tumor biology. Materials and Methods. Clinicopathological and treatment details were recorded for 64 patients achieving pathological complete response from 2010 to 2013. Disease-free survival (DFS), overall survival (OS), and locoregional and systemic recurrence rates were evaluated for these patients. Results. After a median follow-up of 30.5 months (range 11-59 months), the 3-year overall survival (OS) was 94.6% and the 3-year disease-free survival (DFS) was 88.5%. The locoregional and systemic recurrence rates were 4.7% and 3.1%, respectively. Conclusion. In the Indian subcontinent, despite younger patients with aggressive tumor biology, outcome in complete responders is good.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Sinukumar S,Patil P,Engineer R,Desouza A,Saklani Adoi
10.1155/2014/867841subject
Has Abstractpub_date
2014-01-01 00:00:00pages
867841eissn
1687-6121issn
1687-630Xjournal_volume
2014pub_type
杂志文章abstract::We hypothesized that daily intake of nondigestible saccharides delays senescence onset through the improvement of intestinal microflora. Here, we raised senescence accelerated mice prone 8 (SAMP8) on the AIN93 diet (CONT), with sucrose being substituted for 5% of fructooligosaccharide (FOS) or 5% of glucomannan (GM), ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/303184
更新日期:2014-01-01 00:00:00
abstract::Laparoscopic appendectomy has become favored over open surgical methods for its association with decreased postoperative pain, more rapid return to daily activities, and improved cosmetic results. Mini-incision appendectomy was being performed in our clinic for a long time especially in patients with noncomplicated ap...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/138648
更新日期:2014-01-01 00:00:00
abstract:Background/Aim:Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/1262595
更新日期:2019-05-06 00:00:00
abstract::Abstract. Weight recidivism in bariatric surgery failure is multifactorial. It ranges from inappropriate patient selection for primary surgery to technical/anatomic issues related to the original surgery. Most bariatric surgeons and centers focus on primary bariatric surgery while weight recidivism and its complicatio...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/721095
更新日期:2014-01-01 00:00:00
abstract:Objective:To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/5609623
更新日期:2020-09-30 00:00:00
abstract::Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of pati...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6126707
更新日期:2017-01-01 00:00:00
abstract::The technological progress within the range of methods of pancreas imaging and their more common accessibility selects a group of patients requiring a microscopic diagnosis. Percutaneous fine needle aspiration biopsy under the control of ultrasonography (PCFNA/USG) is the method commonly used in determining the charac...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/908963
更新日期:2012-01-01 00:00:00
abstract::Introduction. The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC). Material and Methods. The serum levels of study factors were measured in 73 patients with CRC and in 35 ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/146819
更新日期:2015-01-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2014/386561
更新日期:2014-01-01 00:00:00
abstract:Background:Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), and hepatitis C virus (HCV) infection is a leading cause of CLD, cirrhosis, and hepatocellular carcinoma (HCC). This study is aimed at assessing HRQOL in patients with HCV infection...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6716103
更新日期:2020-01-07 00:00:00
abstract:Background:Our aim was to assess the risk of gastrointestinal (GI) hemorrhage associated with diabetes among patients taking low-dose aspirin (≤325 mg/day). Methods:A systematic search was conducted for publication in English and Chinese using term equivalents for "GI hemorrhage", "aspirin", and "diabetes mellitus" up...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2020/9824615
更新日期:2020-08-03 00:00:00
abstract::We determined comparative efficacy of i-Scan for detection and diagnosis of gastric cancer. Ten patients diagnosed with early gastric cancer based on histopathological findings were analyzed. White light and i-Scan moving images recorded from these patients in twin mode were separated into white light and i-Scan. Twel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/819395
更新日期:2014-01-01 00:00:00
abstract::Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was inject...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8438172
更新日期:2017-01-01 00:00:00
abstract::Background. There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods. A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/2952635
更新日期:2016-01-01 00:00:00
abstract::Aims. We here investigated whether the combination of simvastatin and irinotecan could induce the synergistic effect on colon cancer cells with or without resistance to irinotecan. Methods. We investigated cell proliferation assay and assessed cell death detection ELISA and caspase-3 activity assay of various concentr...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/7891374
更新日期:2016-01-01 00:00:00
abstract::Background. The problems of fungal infections in edentulous have been discussed in literature. Findings show that oral mycosis has an influence on the mycosis of oesophageal mucosa. Based on this we started to follow from 2007 in patients who wear dentures mycological examination, to evaluate changes of yeasts numbers...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/951572
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Preoperative chemoradiotherapy is the standard treatment for patients with locally advanced rectal cancer, although tumor responses vary widely; some patients may achieve a pathologic complete response rate (pCR) after chemoradiotherapy. Controversy exists with regard to the efficacy of different preoperativ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/1373092
更新日期:2017-01-01 00:00:00
abstract::Background. Apoptotic rates in peripheral blood lymphocytes can predict radiation induced normal tissue toxicity. We studied whether apoptosis in lymphocytes has a prognostic value for therapy outcome. Methods. Lymphocytes of 87 rectal cancer patients were ex vivo irradiated with 2 Gy, 8 Gy, or a combination of 2 Gy i...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/5076542
更新日期:2016-01-01 00:00:00
abstract::Hilar cholangiocarcinoma (HCCA) involves a complex anatomical region where bile ducts, arteries, and veins create a complex network. HCCA can lead to biliary strictures at the main hepatic confluence, involving the right and left radicles. Endoscopic drainage of jaundiced patients with HCCA is challenging and carries ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/5161350
更新日期:2019-11-04 00:00:00
abstract::Background. Surgical treatment of hydatid liver disease (HLD) is divided into conservative and radical procedures. While conservative techniques are easier and faster to perform, there is an emerging need to reduce their morbidity and recurrence rates. Our aim was to present and evaluate the efficiency and safety of t...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/1078653
更新日期:2016-01-01 00:00:00
abstract::Background. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a preci...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5037254
更新日期:2016-01-01 00:00:00
abstract::Alterations in gut microbiota are postulated to be an etiologic factor in the pathogenesis of irritable bowel syndrome (IBS). To determine whether IBS patients in China exhibited differences in their gut microbial composition, fecal samples were collected from diarrhea-predominant IBS (IBS-D) and healthy controls and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/6961783
更新日期:2018-06-05 00:00:00
abstract::The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Rece...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/761060
更新日期:2013-01-01 00:00:00
abstract::The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3682836
更新日期:2019-10-17 00:00:00
abstract:Objectives:To determine the prevalence and effect of dietary habits on functional constipation in preschool and early elementary school children in Japan. Study Design:A total of 3595 children aged 3 to 8 years from 28 nursery schools and 22 elementary schools in Yokohama City, Kanagawa Prefecture, Japan, were evaluat...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/3108021
更新日期:2018-02-27 00:00:00
abstract::Objective. The aim of the present study was to investigate whether pentraxin 3 (PTX3) can be a new noninvasive marker for prediction of liver fibrosis in patients with NAFLD. We also aimed to evaluate the relationship between PTX3 and atherosclerosis in patients with NAFLD. Method. Fifty-four male patients with biopsy...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/1417962
更新日期:2016-01-01 00:00:00
abstract::Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. This study investigates the role that selected single n...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2009/591704
更新日期:2009-01-01 00:00:00
abstract:Background/Aims:Delayed bleeding is one of the most serious complications following gastric endoscopic submucosal dissection (ESD) under antithrombotic therapy. As a safety measure, for patients receiving antithrombotic therapy, we covered the ESD ulcer with autologous fibrin glue (prepared using autologous blood) alon...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/2174957
更新日期:2018-03-04 00:00:00
abstract::Aims. The association between Helicobacter pylori (H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue. Methods. A total of 502 inpatients with Rome III confirmed IBS-D and known H. pylori status from 8 hos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/3059201
更新日期:2016-01-01 00:00:00
abstract::Background. Differentiating branch duct from mixed intraductal papillary mucinous neoplasm (BD-IPMN) is problematic, but clinically important as mixed IPMNs are managed surgically, while some BD-IPMN may be followed. Inflammatory mediator proteins (IMPs) have been implicated in acute and chronic inflammatory and malig...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/247309
更新日期:2012-01-01 00:00:00