Abstract:
:Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in animals with experimental ALD in the past, there is still no FDA (Food and Drug Administration) approved therapy for any stage of ALD. With the increasing recognition of the importance of gut microbiota in the onset and development of a variety of diseases, the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients. Potential mechanisms underlying the probiotic function are also discussed.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Li F,Duan K,Wang C,McClain C,Feng Wdoi
10.1155/2016/5491465subject
Has Abstractpub_date
2016-01-01 00:00:00pages
5491465eissn
1687-6121issn
1687-630Xjournal_volume
2016pub_type
杂志文章,评审abstract:Background/Aims:The damage of interstitial cells of Cajal and smooth muscle cells has far-reaching implications in the pathogenesis of gastroparesis in diabetic patients. Gastric electrical stimulation (GES) is an efficient therapy for gastric motility disorders, but the mechanisms of GES require clarification. Method...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/6309157
更新日期:2018-11-13 00:00:00
abstract::The technological progress within the range of methods of pancreas imaging and their more common accessibility selects a group of patients requiring a microscopic diagnosis. Percutaneous fine needle aspiration biopsy under the control of ultrasonography (PCFNA/USG) is the method commonly used in determining the charac...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/908963
更新日期:2012-01-01 00:00:00
abstract:Aim:Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocy...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5705782
更新日期:2019-06-10 00:00:00
abstract::Purpose. By examining the prescribing patterns and inappropriate use of acid suppressive therapy (AST) during hospitalization and at discharge we sought to identify the risk factors associated with such practices. Methods. In this retrospective observational study, inpatient records were reviewed from January 2011 to ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/1973086
更新日期:2016-01-01 00:00:00
abstract::Reorganization of the actin cytoskeleton underlies cell migration in a wide variety of physiological and pathological processes, such as embryonic development, wound healing, and tumor cell invasion. It has been shown that actin assembly and disassembly are precisely regulated by intracellular signaling cascades that ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/930157
更新日期:2015-01-01 00:00:00
abstract::This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder. The lithogenic diet caused elevation of triglycerides, cholesterol, and low-density...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/1343969
更新日期:2020-04-21 00:00:00
abstract:Objectives:The aims of this study were to evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers, and parameters from the complete blood count (CBC) in patients with inflammatory bowel disease (IBD) and their associations with disease activity. Methods:A total of 876 IBD patients, composed of 27...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3467419
更新日期:2020-06-22 00:00:00
abstract::Background. The role of endoglin in the Dukes B rectal cancer is still unexplored. The aim of this study was to examine the expression of endoglin (CD105) in resected rectal cancer and to evaluate the relationship between microvessels density (MVD), clinicopathological factors, and survival rates. Methods. The study i...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/504179
更新日期:2015-01-01 00:00:00
abstract::Background. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a preci...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5037254
更新日期:2016-01-01 00:00:00
abstract:Aim:This study is aimed at comparing gastric cancer T and N staging between virtual monochromatic energy images and fusion images generated by dual-source computed tomography (DSCT) dual-energy mode data acquisition prospectively while measuring the iodine concentration of gastric cancer and lymph nodes at different T ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/5015202
更新日期:2018-12-04 00:00:00
abstract::Objectives. This study is aimed at studying the prevalence and characteristics of different types of headaches in patients with Crohn's disease. Materials and Methods. 51 patients in Crohn's disease group (F/M: 26/25) and 51 patients in control group (F/M: 27/24) were involved. Patients in Crohn's disease group were d...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/6474651
更新日期:2016-01-01 00:00:00
abstract::The hallmark of pancreatic tumours, the desmoplastic reaction, provides a unique microenvironment that affects pancreatic tumour behaviour, its ability to grow and metastasize as well as resist the effects of chemotherapy. Complex molecular interactions and pathways give rise to the desmoplastic reaction. Breakdown or...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/781765
更新日期:2012-01-01 00:00:00
abstract:Background and Aims:To date, there are no validated measures in IBD to assess the level of preparedness for transition into adult health care. The purpose of this study was to develop and assess the reliability and validity of a "Transition Readiness" (TR) measure for adolescents with IBD, as well as to evaluate the le...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5062105
更新日期:2019-06-18 00:00:00
abstract::Purpose. Endoscopic ultrasound (EUS) permits the detailed visualization of clinically significant features of portal hypertension; however, it is an invasive procedure that is not widely available. The aim of this cross-sectional study was to determine whether a correlation exists between the features of portal hypert...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/395345
更新日期:2012-01-01 00:00:00
abstract::Background. Traditionally, rectal cancer surgery is recommended 6 to 8 weeks after completing neoadjuvant chemoradiation. Extending the waiting time may increase the tumor response rate. However, the perioperative complication rate may increase. The purpose of this study was to determine the association between extend...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/7870815
更新日期:2016-01-01 00:00:00
abstract:Background and Aim:Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods:Patients ≥ 50...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6710931
更新日期:2017-01-01 00:00:00
abstract::Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus b...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/8180323
更新日期:2020-11-28 00:00:00
abstract:Aim:This study aims to analyze factors possibly related to the prognosis of duodenal gastrointestinal stromal tumors (DGISTs). Methods:We collected and retrospectively analyzed clinical and pathological data of 62 patients with primary DGISTs. All the patients were hospitalized and received complete surgical resection...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/4812703
更新日期:2018-02-20 00:00:00
abstract::Background and Aims. The study was a repeated evaluation of the experience of capsule endoscopy (CE) in patients with cardiac pacemaker or implantable cardioverter defibrillator (ICD). Patients and Methods. A standardized questionnaire was sent by the manufactors Given Imaging and Olympus to all centers in Germany, Au...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/717408
更新日期:2012-01-01 00:00:00
abstract::Irritable bowel syndrome (IBS) accounts for 25% of gastroenterology output practice, making it one of the most common disorders in this practice. Psychological and social factors may affect the development of this chronic disorder. Furthermore, psychiatric symptoms and psychiatric diseases are highly prevalent in this...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/486067
更新日期:2012-01-01 00:00:00
abstract:Background:The aim of this study was to evaluate the interobserver variability in diagnosing inflammatory bowel disease (IBD)-associated neoplasia among practicing pathologists from China using telepathology, a practice of remote diagnostic consultation increasingly used nationally and internationally, and its comparis...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/8715263
更新日期:2018-04-23 00:00:00
abstract::Background and Aims. Studies have shown effects of diet on gut microbiota. We aimed to identify foods associated with recurrent Clostridium difficile infection (CDI). Methods. In this cross-sectional survey, consecutive patients diagnosed with CDI were identified by electronic medical records. Colitis symptoms and pos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/4514687
更新日期:2016-01-01 00:00:00
abstract:Background:Baicalin (BA) has been shown to have anti-inflammatory and antioxidant activity. Zinc is a nutrient element. Objective:This study is aimed at investigating the antichronic gastric ulcer activity of Zn-Baicalin complex (BA-Zn) and its related mechanisms in an acetic acid-induced gastric ulcer rat model. Res...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/1275486
更新日期:2018-10-28 00:00:00
abstract::Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. This study investigates the role that selected single n...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2009/591704
更新日期:2009-01-01 00:00:00
abstract:Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/9065845
更新日期:2019-08-14 00:00:00
abstract::The most common cause of chronic pancreatitis (CP) is alcohol abuse. The aim of the present study was to identify patients with genetic predisposition to CP abusing alcohol. The question posed was whether CP manifests at a younger age and diabetes mellitus develops earlier in individuals with genetic predisposition. T...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/309156
更新日期:2015-01-01 00:00:00
abstract::Colon cancer is a serious health problem, and novel preventive and therapeutical avenues are urgently called for. Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. Interestingly, bone morphogenetic pr...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/895462
更新日期:2012-01-01 00:00:00
abstract::Aim. Chronic gastritis was assessed serologically, endoscopically and histologically to identify correlations between these methods. Methods. Subjects comprised 319 patients who had provided informed consent. Serological assessment of chronic gastritis was based on the pepsinogen test method. Endoscopic gastritis and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2011/631461
更新日期:2011-01-01 00:00:00
abstract::Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/398585
更新日期:2015-01-01 00:00:00
abstract::The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3682836
更新日期:2019-10-17 00:00:00