Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms.

Abstract:

:Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in animals with experimental ALD in the past, there is still no FDA (Food and Drug Administration) approved therapy for any stage of ALD. With the increasing recognition of the importance of gut microbiota in the onset and development of a variety of diseases, the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients. Potential mechanisms underlying the probiotic function are also discussed.

authors

Li F,Duan K,Wang C,McClain C,Feng W

doi

10.1155/2016/5491465

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

5491465

eissn

1687-6121

issn

1687-630X

journal_volume

2016

pub_type

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