Abstract:
:The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. Finally, 32 fecal specimens extracted from 16 preterm VLBW infants were qualified and analyzed using 16S rRNA gene sequencing. The primary outcome was to evaluate the change of gut microbiota in VLBW infants after combined probiotic supplement. The secondary outcome was to analyze the correlation gut microbial composition and levels of cytokines. We found that probiotic treatment, but not placebo, decreased the α-diversity of gut microbiota in VLBW infants. At the phylum level, probiotic treatment strongly increased the abundance of Firmicutes, whereas that of Proteobacteria was significantly reduced. At the family level, Streptococcaceae and Lactobacillaceae became prevalent after probiotic treatment, while the relative abundance of Enterobacteriaceae was reduced in the meantime. Most notably, significant correlations were observed between Lactobacillaceae abundance and serum cytokine levels. Further studies are required to shed more light on the characteristics of gut microbiota of VLBW neonates. And the modulation of microbiota should be considered to improve the survival rate of VLBW infants.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Li YF,Zhu CR,Gong XL,Li HL,Xiong LK,Wang KJ,Liu GSdoi
10.1155/2019/3682836subject
Has Abstractpub_date
2019-10-17 00:00:00pages
3682836eissn
1687-6121issn
1687-630Xjournal_volume
2019pub_type
杂志文章abstract::Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). In the innate immune system, Toll-like receptors (TLRs) are sensors that recognize bacterial and viral components such as lipopolysaccharide, bacterial DNA, and peptidoglycan. Recent ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2010/362847
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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doi:10.1155/2012/106502
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pub_type: 杂志文章,评审
doi:10.1155/2017/3087904
更新日期:2017-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/9415497
更新日期:2016-01-01 00:00:00
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doi:10.1155/2016/5061640
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journal_title:Gastroenterology research and practice
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doi:10.1155/2015/126532
更新日期:2015-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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doi:10.1155/2012/615051
更新日期:2012-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/473846
更新日期:2014-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2020/4850287
更新日期:2020-09-17 00:00:00
abstract::The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Rece...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/761060
更新日期:2013-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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doi:10.1155/2016/1457357
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journal_title:Gastroenterology research and practice
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doi:10.1155/2009/713937
更新日期:2009-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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doi:10.1155/2014/343849
更新日期:2014-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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abstract:Objectives:The incidence of gastrointestinal stromal tumors (GISTs) located in the colon is rare. Current studies mainly focus on case reports for colonic GISTs. Therefore, a population-based analysis was useful to guide the clinical treatment strategy. Methods:The patients were selected from 2000 to 2015 based on Sur...
journal_title:Gastroenterology research and practice
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doi:10.1155/2019/3849850
更新日期:2019-04-11 00:00:00
abstract:Materials and Methods:This was a multicenter retrospective cohort study. The subjects were patients aged ≥20 years treated for chronic constipation from May 2018 to November 2019 at 12 related institutions. Patients were divided into ≤74 years and ≥75 years old. Elobixibat at 10 mg/day was prescribed for two weeks. We ...
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更新日期:2020-04-28 00:00:00
abstract::Evodiamine (Evo) is an indole alkaloid extracted from the traditional Chinese medicinal herb Evodia rutaecarpa. Evo may regulate gastrointestinal motility, but the evidence is insufficient, and the mechanisms remain unknown. The aim of this study was to investigate the effect of Evo on colonic motility of rats and the...
journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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更新日期:2020-05-19 00:00:00
abstract::Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in...
journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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更新日期:2012-01-01 00:00:00