Abstract:
:The aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS. Sixteen newborn rats were randomized into an IBS model group and a control group. Those in the IBS group were separated from their mothers and were mechanically immobilized and had rectal sensitization with mustard essential oil for 1 week. The control group had no treatment. After 2 weeks, balloon catheters were inflated with 5 or 10 mL of air in the rectums of both groups. BOLD-fMRI was performed and the data analyzed by imaging software. In the IBS model group, rectal stimulation with 5 mL air distension activated the anterior cingulate cortex, insula cortex (IC), prefrontal cortex (PFC), and thalamus, while 10 mL air significantly activated the ACC, IC, PFC, and thalamus in the model, but not controls. IBS model group was hypersensitive to visceral stimulation by rectal balloon inflation. The major brain areas participating in visceral sensation included the IC, PFC, and thalamus.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Zhu X,Zhu X,Chen W,Chen Jdoi
10.1155/2014/473846subject
Has Abstractpub_date
2014-01-01 00:00:00pages
473846eissn
1687-6121issn
1687-630Xjournal_volume
2014pub_type
杂志文章abstract::Hepatocellular carcinoma (HCC) ranks second amongst all causes of cancer deaths globally. It is on a rise in Pakistan and might represent the most common cancer in adult males. Pakistan contributes significantly to global burden of hepatitis C, which is a known risk factor for HCC, and has one of the highest prevalenc...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5942306
更新日期:2016-01-01 00:00:00
abstract::Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/393015
更新日期:2013-01-01 00:00:00
abstract::Epstein-Barr virus (EBV) is an important DNA virus which establishes latent infection in human malignancies. Expression of EBV-encoded genes in the associated tumors is strongly modulated by promoter CpG methylation of EBV genome. This study aimed to explore the methylation status of the promoters of EBV BamHI-A right...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/3804146
更新日期:2017-01-01 00:00:00
abstract::Toll-like receptor (TLR) signaling pathways are strictly coordinated by several mechanisms to regulate adequate innate immune responses. Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS) family proteins, originally identified as negative-feedback regulators in cytokine signaling, are i...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2010/470468
更新日期:2010-01-01 00:00:00
abstract:Background and Aims:Magnetic resonance enterography (MRE) has become an important modality of radiological imaging in the evaluation of Crohn's disease (CD). The aim of this study was to investigate the impact of MRE in the assessment of disease activity and abdominal complications and in the making of therapeutic deci...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3467316
更新日期:2019-12-17 00:00:00
abstract::Background. Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/3126280
更新日期:2016-01-01 00:00:00
abstract:Background:Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), and hepatitis C virus (HCV) infection is a leading cause of CLD, cirrhosis, and hepatocellular carcinoma (HCC). This study is aimed at assessing HRQOL in patients with HCV infection...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6716103
更新日期:2020-01-07 00:00:00
abstract::The aim of the present study was to examine the influence of gastrectomy (GX) on cortical and cancellous bones in rats. Twenty male Sprague-Dawley rats were randomized into the two groups of 10 animals each: a sham operation (control) group and a GX group. Seven weeks after surgery, the bone mineral content and densit...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,收录出版
doi:10.1155/2013/381616
更新日期:2013-01-01 00:00:00
abstract:Background:Environmental factors and genetic mutations have been increasingly recognized as risk factors for chronic pancreatitis (CP). The PRSS1 p.R122H mutation was the first discovered to affect hereditary CP, with 80% penetrance. We performed here a systematic review and meta-analysis to evaluate the associations o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/9505460
更新日期:2017-01-01 00:00:00
abstract:Aims:To evaluate the impact of body mass index (BMI) on the surgical outcome of laparoscopic total mesorectal excision (laTME) for locally advanced rectal cancer (LARC, clinically staged as UICC stage II/III) after neoadjuvant chemoradiotherapy (nCRT). Methods:312 LARC patients undergoing laTME after nCRT were divided...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1509140
更新日期:2017-01-01 00:00:00
abstract:Objectives:The incidence of gastrointestinal stromal tumors (GISTs) located in the colon is rare. Current studies mainly focus on case reports for colonic GISTs. Therefore, a population-based analysis was useful to guide the clinical treatment strategy. Methods:The patients were selected from 2000 to 2015 based on Sur...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3849850
更新日期:2019-04-11 00:00:00
abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/4946068
更新日期:2017-01-01 00:00:00
abstract::We explain the state of the art of the immunohistochemical markers of response in rectal cancers treated with neoadjuvant medical therapies and its implication with prognosis. Neoadjuvant chemoradiotherapy is widely used to improve the outcome of patients with locally advanced rectal cancer, and the evaluation of the ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/2808235
更新日期:2017-01-01 00:00:00
abstract::The most common cause of chronic pancreatitis (CP) is alcohol abuse. The aim of the present study was to identify patients with genetic predisposition to CP abusing alcohol. The question posed was whether CP manifests at a younger age and diabetes mellitus develops earlier in individuals with genetic predisposition. T...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/309156
更新日期:2015-01-01 00:00:00
abstract::The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3682836
更新日期:2019-10-17 00:00:00
abstract::Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was inject...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8438172
更新日期:2017-01-01 00:00:00
abstract::Background and Aim. EUS-guided intervention (EGI) for biliary therapy has been increasingly used in recent years. This report aims to describe the spectrum and experience of EUS-guided interventions in biliary diseases in a single-tertiary center. Methods. All patients with EGI were analyzed retrospectively by retriev...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/680753
更新日期:2012-01-01 00:00:00
abstract:Background and Aim:Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods:Patients ≥ 50...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6710931
更新日期:2017-01-01 00:00:00
abstract::Objective. Balloon enteroscopy (BE) and capsule enteroscopy (CE) are enteroscopy methods that allow examination and treatment of the small bowel. Before the CE and BE era, the small intestine was difficult to access for investigation. Small intestinal tumours are infrequent conditions, but about half of them are malig...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/702536
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:A relationship between intestinal motility and ileostomy prolapse has been suggested but not demonstrated objectively. AIMS:This study evaluated the association between ileostomy prolapse and intestinal dysmotility in children. METHODS:IRB-approved retrospective review of 163 patients with ileostomies (199...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/7182429
更新日期:2017-01-01 00:00:00
abstract::Medicinal plants and probiotics both have very high potential in terms of their antimicrobial activity against antibiotic-resistant enteric pathogens. The probiotics being enteric microorganism do not have any parasitic effect on human beings. They have been an integral part of daily food for centuries. They have been...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/457150
更新日期:2012-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2013/381616.]. ...
journal_title:Gastroenterology research and practice
pub_type: 撤回出版物
doi:10.1155/2020/5109831
更新日期:2020-10-31 00:00:00
abstract::Background. Helicobacter pylori chronically colonizes gastric/duodenal mucosa and induces gastroduodenal disease and vigorous humoral and cellular immune responses. Methods. In order to clarify the immunological changes induced by this infection, we determined the percentage and, as indicated, ratios of the following ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/819842
更新日期:2012-01-01 00:00:00
abstract:Aim:To evaluate the prevalence and risk factors of H. pylori infection in the pediatric and adult population seen at a public hospital in São José do Rio Preto, SP, Brazil. Methods:This is a retrospective study that evaluated 2406 medical records of children, adolescents, and adults with dyspeptic symptoms who underwe...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/8454125
更新日期:2018-09-04 00:00:00
abstract::Background. Previous studies have established norms of 24-hour gastric pH profiles for western countries. This study was designed to establish the pattern for a rural African population with a high incidence of oesophageal cancer. Methods. After lower oesophageal manometry a probe was placed 10 cm distal to the lower ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/658106
更新日期:2015-01-01 00:00:00
abstract::Evodiamine (Evo) is an indole alkaloid extracted from the traditional Chinese medicinal herb Evodia rutaecarpa. Evo may regulate gastrointestinal motility, but the evidence is insufficient, and the mechanisms remain unknown. The aim of this study was to investigate the effect of Evo on colonic motility of rats and the...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/8610653
更新日期:2020-04-03 00:00:00
abstract:Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/9065845
更新日期:2019-08-14 00:00:00
abstract:Background and Aims:Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients. Methods:All UC pati...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/4195968
更新日期:2018-10-03 00:00:00
abstract:Background and Aims:To date, there are no validated measures in IBD to assess the level of preparedness for transition into adult health care. The purpose of this study was to develop and assess the reliability and validity of a "Transition Readiness" (TR) measure for adolescents with IBD, as well as to evaluate the le...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5062105
更新日期:2019-06-18 00:00:00
abstract::Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of pati...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6126707
更新日期:2017-01-01 00:00:00