The application of functional magnetic resonance imaging in an infant rat model of irritable bowel syndrome.

Abstract:

:The aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS. Sixteen newborn rats were randomized into an IBS model group and a control group. Those in the IBS group were separated from their mothers and were mechanically immobilized and had rectal sensitization with mustard essential oil for 1 week. The control group had no treatment. After 2 weeks, balloon catheters were inflated with 5 or 10 mL of air in the rectums of both groups. BOLD-fMRI was performed and the data analyzed by imaging software. In the IBS model group, rectal stimulation with 5 mL air distension activated the anterior cingulate cortex, insula cortex (IC), prefrontal cortex (PFC), and thalamus, while 10 mL air significantly activated the ACC, IC, PFC, and thalamus in the model, but not controls. IBS model group was hypersensitive to visceral stimulation by rectal balloon inflation. The major brain areas participating in visceral sensation included the IC, PFC, and thalamus.

authors

Zhu X,Zhu X,Chen W,Chen J

doi

10.1155/2014/473846

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

473846

eissn

1687-6121

issn

1687-630X

journal_volume

2014

pub_type

杂志文章
  • Hepatocellular Carcinoma in Pakistan: National Trends and Global Perspective.

    abstract::Hepatocellular carcinoma (HCC) ranks second amongst all causes of cancer deaths globally. It is on a rise in Pakistan and might represent the most common cancer in adult males. Pakistan contributes significantly to global burden of hepatitis C, which is a known risk factor for HCC, and has one of the highest prevalenc...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5942306

    authors: Hafeez Bhatti AB,Dar FS,Waheed A,Shafique K,Sultan F,Shah NH

    更新日期:2016-01-01 00:00:00

  • Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer.

    abstract::Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/393015

    authors: Carrasco G,Corvalan AH

    更新日期:2013-01-01 00:00:00

  • The Methylation Status and Expression of Epstein-Barr Virus Early Genes BARF1 and BHRF1 in Epstein-Barr Virus-Associated Gastric Carcinomas.

    abstract::Epstein-Barr virus (EBV) is an important DNA virus which establishes latent infection in human malignancies. Expression of EBV-encoded genes in the associated tumors is strongly modulated by promoter CpG methylation of EBV genome. This study aimed to explore the methylation status of the promoters of EBV BamHI-A right...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/3804146

    authors: Li J,Liu W,Che K,Zhang Y,Zhao Z,Luo B

    更新日期:2017-01-01 00:00:00

  • SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases.

    abstract::Toll-like receptor (TLR) signaling pathways are strictly coordinated by several mechanisms to regulate adequate innate immune responses. Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS) family proteins, originally identified as negative-feedback regulators in cytokine signaling, are i...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2010/470468

    authors: Fujimoto M,Naka T

    更新日期:2010-01-01 00:00:00

  • Changes in the Management of Patients with Crohn's Disease Based on Magnetic Resonance Enterography Patterns.

    abstract:Background and Aims:Magnetic resonance enterography (MRE) has become an important modality of radiological imaging in the evaluation of Crohn's disease (CD). The aim of this study was to investigate the impact of MRE in the assessment of disease activity and abdominal complications and in the making of therapeutic deci...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/3467316

    authors: Chinem ESS,Esberard BC,Moreira ADL,Barbassa TG,da Cunha GM,Carneiro AJV,de Souza HS,Carvalho ATP

    更新日期:2019-12-17 00:00:00

  • Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats.

    abstract::Background. Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/3126280

    authors: Dembiński A,Warzecha Z,Ceranowicz P,Dembiński M,Cieszkowski J,Gosiewski T,Bulanda M,Kuśnierz-Cabala B,Gałązka K,Konturek PC

    更新日期:2016-01-01 00:00:00

  • Health-Related Quality of Life among Patients with Hepatitis C Virus Infection: A Cross-Sectional Study in Jianping County of Liaoning Province, China.

    abstract:Background:Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), and hepatitis C virus (HCV) infection is a leading cause of CLD, cirrhosis, and hepatocellular carcinoma (HCC). This study is aimed at assessing HRQOL in patients with HCV infection...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/6716103

    authors: Zhang H,Ren R,Liu J,Mao Y,Pan G,Men K,Ma L

    更新日期:2020-01-07 00:00:00

  • Influence of gastrectomy on cortical and cancellous bones in rats.

    abstract::The aim of the present study was to examine the influence of gastrectomy (GX) on cortical and cancellous bones in rats. Twenty male Sprague-Dawley rats were randomized into the two groups of 10 animals each: a sham operation (control) group and a GX group. Seven weeks after surgery, the bone mineral content and densit...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,收录出版

    doi:10.1155/2013/381616

    authors: Iwamoto J,Sato Y,Matsumoto H

    更新日期:2013-01-01 00:00:00

  • The Differential Role of Human Cationic Trypsinogen (PRSS1) p.R122H Mutation in Hereditary and Nonhereditary Chronic Pancreatitis: A Systematic Review and Meta-Analysis.

    abstract:Background:Environmental factors and genetic mutations have been increasingly recognized as risk factors for chronic pancreatitis (CP). The PRSS1 p.R122H mutation was the first discovered to affect hereditary CP, with 80% penetrance. We performed here a systematic review and meta-analysis to evaluate the associations o...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/9505460

    authors: Hu C,Wen L,Deng L,Zhang C,Lugea A,Su HY,Waldron RT,Pandol SJ,Xia Q

    更新日期:2017-01-01 00:00:00

  • Impact of Body Mass Index on Surgical and Oncological Outcomes in Laparoscopic Total Mesorectal Excision for Locally Advanced Rectal Cancer after Neoadjuvant 5-Fluorouracil-Based Chemoradiotherapy.

    abstract:Aims:To evaluate the impact of body mass index (BMI) on the surgical outcome of laparoscopic total mesorectal excision (laTME) for locally advanced rectal cancer (LARC, clinically staged as UICC stage II/III) after neoadjuvant chemoradiotherapy (nCRT). Methods:312 LARC patients undergoing laTME after nCRT were divided...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/1509140

    authors: Sun Y,Chi P

    更新日期:2017-01-01 00:00:00

  • Colonic Gastrointestinal Stromal Tumor: A Population-Based Analysis of Incidence and Survival.

    abstract:Objectives:The incidence of gastrointestinal stromal tumors (GISTs) located in the colon is rare. Current studies mainly focus on case reports for colonic GISTs. Therefore, a population-based analysis was useful to guide the clinical treatment strategy. Methods:The patients were selected from 2000 to 2015 based on Sur...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/3849850

    authors: Liu Z,Sun Y,Li Y,Zhao J,Wu S,Meng Z,Wu H

    更新日期:2019-04-11 00:00:00

  • Colorectal Malignancy in a Prospective Irish Inflammatory Bowel Disease Population 15 Years Since Diagnosis: Comparison with the EC-IBD Cohort.

    abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/4946068

    authors: Shuhaibar M,O'Morain C

    更新日期:2017-01-01 00:00:00

  • Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art.

    abstract::We explain the state of the art of the immunohistochemical markers of response in rectal cancers treated with neoadjuvant medical therapies and its implication with prognosis. Neoadjuvant chemoradiotherapy is widely used to improve the outcome of patients with locally advanced rectal cancer, and the evaluation of the ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/2808235

    authors: Del Gobbo A,Ferrero S

    更新日期:2017-01-01 00:00:00

  • The genetic predisposition and its impact on the diabetes mellitus development in patients with alcoholic chronic pancreatitis.

    abstract::The most common cause of chronic pancreatitis (CP) is alcohol abuse. The aim of the present study was to identify patients with genetic predisposition to CP abusing alcohol. The question posed was whether CP manifests at a younger age and diabetes mellitus develops earlier in individuals with genetic predisposition. T...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/309156

    authors: Madro A,Ciesielka M,Celinski K,Slomka M,Czechowska G,Kurzepa J,Kaszelan-Szczerbinska B,Buszewicz G,Madro R

    更新日期:2015-01-01 00:00:00

  • Beneficial Effects of Probiotic Treatment on Gut Microbiota in Very Low Birth Weight Infants.

    abstract::The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/3682836

    authors: Li YF,Zhu CR,Gong XL,Li HL,Xiong LK,Wang KJ,Liu GS

    更新日期:2019-10-17 00:00:00

  • Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis.

    abstract::Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was inject...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/8438172

    authors: Vigna SR

    更新日期:2017-01-01 00:00:00

  • The Spectrum of Endoscopic Ultrasound Intervention in Biliary Diseases: A Single Center's Experience in 31 Cases.

    abstract::Background and Aim. EUS-guided intervention (EGI) for biliary therapy has been increasingly used in recent years. This report aims to describe the spectrum and experience of EUS-guided interventions in biliary diseases in a single-tertiary center. Methods. All patients with EGI were analyzed retrospectively by retriev...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/680753

    authors: Attasaranya S,Netinasunton N,Jongboonyanuparp T,Sottisuporn J,Witeerungrot T,Pirathvisuth T,Ovartlarnporn B

    更新日期:2012-01-01 00:00:00

  • Proximal Sessile Serrated Adenomas Are More Prevalent in Caucasians, and Gastroenterologists Are Better Than Nongastroenterologists at Their Detection.

    abstract:Background and Aim:Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods:Patients ≥ 50...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/6710931

    authors: Parikh MP,Muthukuru S,Jobanputra Y,Naha K,Gupta NM,Wadhwa V,Lopez R,Thota PN,Sanaka MR

    更新日期:2017-01-01 00:00:00

  • Small intestinal tumours.

    abstract::Objective. Balloon enteroscopy (BE) and capsule enteroscopy (CE) are enteroscopy methods that allow examination and treatment of the small bowel. Before the CE and BE era, the small intestine was difficult to access for investigation. Small intestinal tumours are infrequent conditions, but about half of them are malig...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/702536

    authors: Kopáčová M,Rejchrt S,Bureš J,Tachecí I

    更新日期:2013-01-01 00:00:00

  • Ileostomy Prolapse in Children with Intestinal Dysmotility.

    abstract:BACKGROUND:A relationship between intestinal motility and ileostomy prolapse has been suggested but not demonstrated objectively. AIMS:This study evaluated the association between ileostomy prolapse and intestinal dysmotility in children. METHODS:IRB-approved retrospective review of 163 patients with ileostomies (199...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/7182429

    authors: Sparks EA,Velazco CS,Fullerton BS,Fisher JG,Khan FA,Hall AM,Jaksic T,Rodriguez L,Modi BP

    更新日期:2017-01-01 00:00:00

  • Development of probiotic candidate in combination with essential oils from medicinal plant and their effect on enteric pathogens: a review.

    abstract::Medicinal plants and probiotics both have very high potential in terms of their antimicrobial activity against antibiotic-resistant enteric pathogens. The probiotics being enteric microorganism do not have any parasitic effect on human beings. They have been an integral part of daily food for centuries. They have been...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/457150

    authors: Shipradeep,Karmakar S,Sahay Khare R,Ojha S,Kundu K,Kundu S

    更新日期:2012-01-01 00:00:00

  • Retracted: Influence of Gastrectomy on Cortical and Cancellous Bones in Rats.

    abstract::[This retracts the article DOI: 10.1155/2013/381616.]. ...

    journal_title:Gastroenterology research and practice

    pub_type: 撤回出版物

    doi:10.1155/2020/5109831

    authors: Research And Practice G

    更新日期:2020-10-31 00:00:00

  • Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients.

    abstract::Background. Helicobacter pylori chronically colonizes gastric/duodenal mucosa and induces gastroduodenal disease and vigorous humoral and cellular immune responses. Methods. In order to clarify the immunological changes induced by this infection, we determined the percentage and, as indicated, ratios of the following ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/819842

    authors: Satoh Y,Ogawara H,Kawamura O,Kusano M,Murakami H

    更新日期:2012-01-01 00:00:00

  • Epidemiological and Clinical-Pathological Aspects of Helicobacter pylori Infection in Brazilian Children and Adults.

    abstract:Aim:To evaluate the prevalence and risk factors of H. pylori infection in the pediatric and adult population seen at a public hospital in São José do Rio Preto, SP, Brazil. Methods:This is a retrospective study that evaluated 2406 medical records of children, adolescents, and adults with dyspeptic symptoms who underwe...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/8454125

    authors: Toscano EP,Madeira FF,Dutra-Rulli MP,Gonçalves LOM,Proença MA,Borghi VS,Cadamuro ACT,Mazzale GW,Acayaba R,Silva AE

    更新日期:2018-09-04 00:00:00

  • 24-Hour Measurement of Gastric pH in Rural South Africa.

    abstract::Background. Previous studies have established norms of 24-hour gastric pH profiles for western countries. This study was designed to establish the pattern for a rural African population with a high incidence of oesophageal cancer. Methods. After lower oesophageal manometry a probe was placed 10 cm distal to the lower ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/658106

    authors: Sammon AM,Ndebia EJ,Umapathy E,Iputo JE

    更新日期:2015-01-01 00:00:00

  • An Indole Alkaloid Extracted from Evodia rutaecarpa Inhibits Colonic Motility of Rats In Vitro.

    abstract::Evodiamine (Evo) is an indole alkaloid extracted from the traditional Chinese medicinal herb Evodia rutaecarpa. Evo may regulate gastrointestinal motility, but the evidence is insufficient, and the mechanisms remain unknown. The aim of this study was to investigate the effect of Evo on colonic motility of rats and the...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/8610653

    authors: Wang GX,Xiang YL,Wang HG,Miu YD,Yu G

    更新日期:2020-04-03 00:00:00

  • Safety of Simultaneous Hepatectomy and Splenectomy in the Treatment of Hepatocellular Carcinoma Complicated with Hypersplenism: A Meta-analysis.

    abstract:Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9065845

    authors: Liu X,Chen Z,Yu M,Zhou W,Zhi X,Li T

    更新日期:2019-08-14 00:00:00

  • Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study.

    abstract:Background and Aims:Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients. Methods:All UC pati...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/4195968

    authors: Pugliese D,Aratari A,Festa S,Ferraro PM,Monterubbianesi R,Guidi L,Scribano ML,Papi C,Armuzzi A

    更新日期:2018-10-03 00:00:00

  • Initial Development and Validation of a Transition Readiness Scale for Adolescents with Inflammatory Bowel Disease.

    abstract:Background and Aims:To date, there are no validated measures in IBD to assess the level of preparedness for transition into adult health care. The purpose of this study was to develop and assess the reliability and validity of a "Transition Readiness" (TR) measure for adolescents with IBD, as well as to evaluate the le...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/5062105

    authors: Hammerman O,Bayatra A,Turner D,Levine A,Shamir R,Assa A,Wilschanski M,Bachner YG,Israeli E

    更新日期:2019-06-18 00:00:00

  • Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience.

    abstract::Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of pati...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/6126707

    authors: Buechter M,Manka P,Heinemann FM,Lindemann M,Juntermanns B,Canbay A,Gerken G,Kahraman A

    更新日期:2017-01-01 00:00:00