Abstract:
:Epstein-Barr virus (EBV) is an important DNA virus which establishes latent infection in human malignancies. Expression of EBV-encoded genes in the associated tumors is strongly modulated by promoter CpG methylation of EBV genome. This study aimed to explore the methylation status of the promoters of EBV BamHI-A rightward frame 1 (BARF1) and BamHI-H rightward open reading frame 1 (BHRF1) and their influence on transcriptional expression, to further understand the roles of BARF1 and BHRF1 in the occurrence of EBV-associated cancer. We evaluated the methylation status of BARF1 and BHRF1 promoters in 43 EBV-associated gastric carcinoma (EBVaGC) tissues and EBV-positive cell lines. Their expressions were evaluated by real-time quantitative PCR. We found that the promoters of BARF1 and BHRF1 were methylated by varying degrees in different EBV-positive cell lines and were almost hypermethylated in all EBVaGC tissues. The methylation status of BARF1 and BHRF1 promoters were significantly reduced by 5-Aza-CdR along with the increasing gene expressions. Hypermethylation of Ap and Hp mediates the frequent silencing of BARF1 and BHRF1 in EBV-associated tumors, which could be reactivated by a demethylation agent, suggesting that promoter demethylation and activation is important for BARF1 and BHRF1 transcription and their further action.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Li J,Liu W,Che K,Zhang Y,Zhao Z,Luo Bdoi
10.1155/2017/3804146subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3804146eissn
1687-6121issn
1687-630Xjournal_volume
2017pub_type
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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doi:10.1155/2014/867841
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更新日期:2018-02-18 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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更新日期:2018-03-04 00:00:00
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2014/530140
更新日期:2014-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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doi:10.1155/2018/8454125
更新日期:2018-09-04 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5491465
更新日期:2016-01-01 00:00:00