Abstract:
:Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the role of HP in the multistep cascade of GC. We attempt to define the role of the Operative Link for Gastritis Assessment (OLGA) staging system in assessing the risk of GC. The epigenetic bases of chronic gastritis, mainly DNA methylation, are presented through examples such as (i) the methylation of the promoter region of E-cadherin in HP-induced chronic gastritis and its reversion after HP eradication and (ii) the association of methylation of the promoter region of Reprimo, a p53-mediated cell cycle arrest gene, with aggressive HP strains in high risk areas for GC. In addition, we discuss the finding of RPRM as a circulating cell-free DNA, offering the opportunity for noninvasive risk assessment of GC. Finally, the integration of OLGA and tissue biomarkers, by systems pathology approach, suggests that severe atrophy has a greater risk for GC development if, in addition, overexpressed p73. This trial is registered with ClinicalTrials.gov NCT01774266.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Carrasco G,Corvalan AHdoi
10.1155/2013/393015subject
Has Abstractpub_date
2013-01-01 00:00:00pages
393015eissn
1687-6121issn
1687-630Xjournal_volume
2013pub_type
杂志文章abstract::Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been established as treatment options for patients with peritoneal metastases or peritoneal mesothelioma. However, this novel treatment strategy remains associated with a large percentage of local-regional treatment failures. These ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/752643
更新日期:2012-01-01 00:00:00
abstract::Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis m...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/979506
更新日期:2012-01-01 00:00:00
abstract:Aim:This study aims to analyze factors possibly related to the prognosis of duodenal gastrointestinal stromal tumors (DGISTs). Methods:We collected and retrospectively analyzed clinical and pathological data of 62 patients with primary DGISTs. All the patients were hospitalized and received complete surgical resection...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/4812703
更新日期:2018-02-20 00:00:00
abstract:OBJECTIVE:To investigate the differences in the results of esophageal function tests for functional heartburn (FH) and reflux hypersensitivity (RH). METHODS:Patients with FH and RH and healthy volunteers (HVs) from the Department of Gastroenterology, Beijing Anzhen Hospital and Beijing Chao-Yang hospital, who underwen...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/3596148
更新日期:2017-01-01 00:00:00
abstract::Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/398585
更新日期:2015-01-01 00:00:00
abstract::Irritable bowel syndrome (IBS) accounts for 25% of gastroenterology output practice, making it one of the most common disorders in this practice. Psychological and social factors may affect the development of this chronic disorder. Furthermore, psychiatric symptoms and psychiatric diseases are highly prevalent in this...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/486067
更新日期:2012-01-01 00:00:00
abstract::Background and Study Aims. When performing endoscopic submucosal dissection (ESD) for patients on antithrombotic agents, the frequency of delayed bleeding is expected to increase. The endoscopic polyglycolic acid (PGA) felt and fibrin glue sealing method could be a new method for prevention of delayed bleeding. Patien...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/1457357
更新日期:2016-01-01 00:00:00
abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/4946068
更新日期:2017-01-01 00:00:00
abstract::Background. No predictive or prognostic biomarker is available for patients with locally advanced rectal cancer (LARC) undergoing perioperative chemoradiotherapy (CRT). Members of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases EGFR (HER1, ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HE...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/3481578
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to establish a retrospective evaluation and comparison of the hydrogen/methane (H2/CH4) breath test and genetic test (C/T-13910 polymorphism) results in lactose malabsorption testing. In total 263 consecutive patients with suspected lactose malabsorption were included in this study. They unde...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/464382
更新日期:2014-01-01 00:00:00
abstract::The objective of this study was to evaluate the possibility to undertake an ileocolic resection in complex Crohn's disease using a minimal open abdominal access using standard laparoscopic instruments. The incision was carried out over the previous McBurney scar, with a mean length of 6 cm. Seventy-two patients with c...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6019435
更新日期:2020-02-28 00:00:00
abstract:Background and Aims:Functional gastrointestinal disorders (FGDs) are multifactorial disorders of the gut-brain interaction. This study investigated the prevalence of Axis I and spectrum disorders in patients with FGD and established the link between FGDs and psychopathological dimensions. Methods:A total of 135 consec...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1953435
更新日期:2017-01-01 00:00:00
abstract::Background and Aims. Studies have shown effects of diet on gut microbiota. We aimed to identify foods associated with recurrent Clostridium difficile infection (CDI). Methods. In this cross-sectional survey, consecutive patients diagnosed with CDI were identified by electronic medical records. Colitis symptoms and pos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/4514687
更新日期:2016-01-01 00:00:00
abstract::Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon. If a CLL...
journal_title:Gastroenterology research and practice
pub_type:
doi:10.1155/2008/742146
更新日期:2008-01-01 00:00:00
abstract::Objective. We aimed to determine the effectiveness of endoscopic retrograde cholangiopancreatography (ERCP) in patients with inoperable perihilar cholangiocarcinoma and establish the incidence of cholangitis development following ERCP. Material and Method. This retrospective study enrolled patients diagnosed with inop...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/508286
更新日期:2014-01-01 00:00:00
abstract::Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was inject...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8438172
更新日期:2017-01-01 00:00:00
abstract:Materials and Methods:This was a multicenter retrospective cohort study. The subjects were patients aged ≥20 years treated for chronic constipation from May 2018 to November 2019 at 12 related institutions. Patients were divided into ≤74 years and ≥75 years old. Elobixibat at 10 mg/day was prescribed for two weeks. We ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/9656040
更新日期:2020-04-28 00:00:00
abstract:Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/9065845
更新日期:2019-08-14 00:00:00
abstract::Myeloproliferative neoplasms (MPNs) are the leading cause of Budd-Chiari syndrome (BCS), and the C allele of JAK2 rs4495487 was reported to be an additional candidate locus that contributed to MPNs. In the present study, we examined the role of JAK2 rs4495487 in the etiology and clinical presentation of Chinese BCS pa...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/807865
更新日期:2015-01-01 00:00:00
abstract:Background:Rifaximin is effective in relieving pain symptoms with IBS patients, although the mechanisms were not clear. The aims of the research were to investigate whether the visceral hyperalgesia was alleviated by rifaximin via TRPV1 channel in rats. Methods:Rats were subjected to water avoidance stress (WAS) and w...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/4078681
更新日期:2020-07-20 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a chronic cholestatic liver condition characterized by the immune-mediated damage of the intrahepatic bile ducts. Polymorphisms of vitamin D receptor (VDR) are considered to contribute to its pathogenesis however their incidence varies in different populations and their potential ass...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/408723
更新日期:2012-01-01 00:00:00
abstract::Survival rates among HIV patients have significantly improved since the introduction of antiretroviral therapy (ART) in HIV management. However, persistent disease progression and clinical complications in virally suppressed individuals point to additional contributing factors other than HIV replication; microbial tra...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2014/803185
更新日期:2014-01-01 00:00:00
abstract::Objective. Here, we aim to investigate the microRNA (miR) profiling in human gastric cancer (GC). Methods. Tumoral and matched peritumoral gastric specimens were collected from 12 GC patients who underwent routine surgery. A high-throughput miR sequencing method was applied to detect the aberrantly expressed miRs in a...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1526981
更新日期:2017-01-01 00:00:00
abstract:Aim:Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocy...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5705782
更新日期:2019-06-10 00:00:00
abstract::Background. Apoptotic rates in peripheral blood lymphocytes can predict radiation induced normal tissue toxicity. We studied whether apoptosis in lymphocytes has a prognostic value for therapy outcome. Methods. Lymphocytes of 87 rectal cancer patients were ex vivo irradiated with 2 Gy, 8 Gy, or a combination of 2 Gy i...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/5076542
更新日期:2016-01-01 00:00:00
abstract::Endoscopic retrograde cholangiopancreatography (ERCP) can fail in 3-10% of the cases even in experienced hands. Although percutaneous transhepatic cholangiography (PTC) and surgery are the traditional alternatives, there are morbidity and mortality associated with both. In this paper, we have discussed the efficacy an...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/869214
更新日期:2013-01-01 00:00:00
abstract::Although the thread-traction (TT) method has been found useful during endoscopic submucosal dissection (ESD) for early gastric cancers, the movement of the thread interferes with the movement of the endoscope, and the lesion can only be pulled to the mouth side. We have developed the novel TT method using a sheath of ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/9415497
更新日期:2016-01-01 00:00:00
abstract:Background and Aims:Balloon-assisted enteroscopy (BAE) can be used to retrieve small intestinal foreign bodies (FBs). Here, we aimed at exploring the clinical usefulness of BAE for the retrieval of small intestinal FBs. Methods:We retrospectively reviewed the medical records of 34 patients who underwent BAE to retriev...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3814267
更新日期:2020-05-19 00:00:00
abstract::Objective. Role of dysfunction of the sphincter of Oddi (SO) in choledocholithiasis is controversial. This study was to evaluate SO motor activity in patients with common bile duct (CBD) stones in the Han population of China. Patients and Methods. In this study, 76 patients with CBD stones were enrolled in a single te...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/9031438
更新日期:2017-01-01 00:00:00
abstract::Background. Endoscopic-Ultrasonography- (EUS-) guided puncture and drainage of pancreatic pseudocyst is currently one of the most widely accepted nonsurgical treatments. To date, this technique has only been used for pancreatic pseudocysts adhesive to the gastric wall. This study introduces the technique of EUS-guided...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/785483
更新日期:2013-01-01 00:00:00