Colorectal Malignancy in a Prospective Irish Inflammatory Bowel Disease Population 15 Years Since Diagnosis: Comparison with the EC-IBD Cohort.

Abstract:

Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009. Patients who developed malignancies were logged electronically with verification of the site and histology. Results:Of the initial 192 patients, 133 were included in the 15-year follow-up. Of those, 80 (60.2%) had UC and 53 (39.8%) had CD. There were 82 (61.7%) males and 51 (38.3%) females. Six patients had extraintestinal malignancy; however, there was no CRC related to IBD noted in our cohort. Four of the 6 identified cases had UC (64%) with a mean age of 54.25 years at the time of cancer diagnosis, whereas the two CD patients had a mean age of 51.5 years at the time of cancer diagnosis. Conclusion:CRC was not observed in our cohort. The six extraintestinal malignancies did not show significant relation to IBD. The high total colectomy rate (in the prebiological therapy era) may have contributed to low malignancy rate.

authors

Shuhaibar M,O'Morain C

doi

10.1155/2017/4946068

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

4946068

eissn

1687-6121

issn

1687-630X

journal_volume

2017

pub_type

杂志文章
  • Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma.

    abstract:Objective:The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods:33 patients of...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/7103915

    authors: Liang Y,Zheng G,Yin W,Song H,Li C,Tian L,Yang D

    更新日期:2019-02-04 00:00:00

  • Experience with Balloon Dilatation in Crohn's and Non-Crohn's Benign Small-Bowel Strictures: Is There a Difference?

    abstract:Background/Aim:Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/1262595

    authors: Tsuboi A,Oka S,Tanaka S,Iio S,Otani I,Kunihara S,Hayashi R,Chayama K

    更新日期:2019-05-06 00:00:00

  • Clinical outcome of patients with complete pathological response to neoadjuvant chemoradiotherapy for locally advanced rectal cancers: the Indian scenario.

    abstract::Introduction. Neoadjuvant chemoradiotherapy and total mesorectal excision are considered the standard treatment for locally advanced rectal cancer. Various studies have reported pathological downstaging and a complete pathological response rate of 15%-27% following neoadjuvant chemoradiotherapy which has translated in...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/867841

    authors: Sinukumar S,Patil P,Engineer R,Desouza A,Saklani A

    更新日期:2014-01-01 00:00:00

  • Manometric Measurement of the Sphincter of Oddi in Patients with Common Bile Duct Stones: A Consecutive Study of the Han Population of China.

    abstract::Objective. Role of dysfunction of the sphincter of Oddi (SO) in choledocholithiasis is controversial. This study was to evaluate SO motor activity in patients with common bile duct (CBD) stones in the Han population of China. Patients and Methods. In this study, 76 patients with CBD stones were enrolled in a single te...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/9031438

    authors: Feng Y,Zhang J,Jiao C,Zhu H,Cheng W,Xu S,Xiao B,Ni J,Chen X

    更新日期:2017-01-01 00:00:00

  • Current advances in the diagnosis and treatment of nonerosive reflux disease.

    abstract::Nonerosive reflux disease (NERD) is a distinct pattern of gastroesophageal reflux disease (GERD). It is defined as a subcategory of GERD characterized by troublesome reflux-related symptoms in the absence of esophageal mucosal erosions/breaks at conventional endoscopy. In clinical practice, patients with reflux sympto...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/653989

    authors: Chen CL,Hsu PI

    更新日期:2013-01-01 00:00:00

  • Patients' Educational Program Could Improve Azathioprine Adherence in Crohn's Disease Maintenance Therapy.

    abstract:Aim:To determine the risk factors of nonadherence to azathioprine (AZA) maintenance therapy for Crohn's disease (CD) and to evaluate the influence of patients' educational program on adherence to AZA maintenance therapy. Methods:Patients receiving AZA as maintenance therapy for CD were enrolled. Demographic data, clin...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/6848293

    authors: Wang L,Fan R,Zhang C,Hong L,Zhang T,Wang Z,Zhong J

    更新日期:2020-04-20 00:00:00

  • 24-Hour Measurement of Gastric pH in Rural South Africa.

    abstract::Background. Previous studies have established norms of 24-hour gastric pH profiles for western countries. This study was designed to establish the pattern for a rural African population with a high incidence of oesophageal cancer. Methods. After lower oesophageal manometry a probe was placed 10 cm distal to the lower ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/658106

    authors: Sammon AM,Ndebia EJ,Umapathy E,Iputo JE

    更新日期:2015-01-01 00:00:00

  • Epidemiological and Clinical-Pathological Aspects of Helicobacter pylori Infection in Brazilian Children and Adults.

    abstract:Aim:To evaluate the prevalence and risk factors of H. pylori infection in the pediatric and adult population seen at a public hospital in São José do Rio Preto, SP, Brazil. Methods:This is a retrospective study that evaluated 2406 medical records of children, adolescents, and adults with dyspeptic symptoms who underwe...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/8454125

    authors: Toscano EP,Madeira FF,Dutra-Rulli MP,Gonçalves LOM,Proença MA,Borghi VS,Cadamuro ACT,Mazzale GW,Acayaba R,Silva AE

    更新日期:2018-09-04 00:00:00

  • Health-Related Quality of Life among Patients with Hepatitis C Virus Infection: A Cross-Sectional Study in Jianping County of Liaoning Province, China.

    abstract:Background:Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), and hepatitis C virus (HCV) infection is a leading cause of CLD, cirrhosis, and hepatocellular carcinoma (HCC). This study is aimed at assessing HRQOL in patients with HCV infection...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/6716103

    authors: Zhang H,Ren R,Liu J,Mao Y,Pan G,Men K,Ma L

    更新日期:2020-01-07 00:00:00

  • Utility of Endoscopic Examination in the Diagnosis of Acute Graft-versus-Host Disease in the Lower Gastrointestinal Tract.

    abstract:Background and Aims:We retrospectively investigated the incidence of acute graft-versus-host disease (GVHD) in the lower gastrointestinal (GI) tract and the diagnostic accuracy of endoscopy. Methods:Of 1231 patients who underwent allogeneic hematopoietic stem cell transplantation between January 2005 and December 2014...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/2145986

    authors: Nomura K,Iizuka T,Kaji D,Yamamoto H,Kuribayashi Y,Tanaka M,Furuhata T,Yamashita S,Kikuchi D,Matsui A,Mitani T,Ota Y,Taniguchi S,Hoteya S

    更新日期:2017-01-01 00:00:00

  • The Efficacy and Safety of Elobixibat for the Elderly with Chronic Constipation: A Multicenter Retrospective Cohort Study.

    abstract:Materials and Methods:This was a multicenter retrospective cohort study. The subjects were patients aged ≥20 years treated for chronic constipation from May 2018 to November 2019 at 12 related institutions. Patients were divided into ≤74 years and ≥75 years old. Elobixibat at 10 mg/day was prescribed for two weeks. We ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/9656040

    authors: Tomie A,Yoshida N,Kugai M,Hirose R,Dohi O,Inoue K,Okuda K,Motoyoshi T,Fukumoto K,Inagaki Y,Yoriki H,Inada Y,Okuda T,Hasegawa D,Ogiso K,Murakami T,Soga K,Rani RA,Yoshida N,Itoh Y

    更新日期:2020-04-28 00:00:00

  • Nutrition and Helicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome.

    abstract::Helicobacter pylori colonizes the stomachs of greater than 50% of the world's human population making it arguably one of the most successful bacterial pathogens. Chronic H. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with H. pylori is associated ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3019362

    authors: Haley KP,Gaddy JA

    更新日期:2016-01-01 00:00:00

  • Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats.

    abstract::Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus b...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/8180323

    authors: Matah Marte VM,Ateufack G,Mbiantcha M,Atsamo AD,Adjouzem CF,Djuichou Nguemnang SF,Tsafack EG,Yousseu Nana W,Madjo Kouam YK,Ngoufack Azanze E

    更新日期:2020-11-28 00:00:00

  • Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice.

    abstract::This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder. The lithogenic diet caused elevation of triglycerides, cholesterol, and low-density...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/1343969

    authors: Chen G,Wu S

    更新日期:2020-04-21 00:00:00

  • Outcomes of endoscopic-ultrasound-guided cholangiopancreatography: a literature review.

    abstract::Endoscopic retrograde cholangiopancreatography (ERCP) can fail in 3-10% of the cases even in experienced hands. Although percutaneous transhepatic cholangiography (PTC) and surgery are the traditional alternatives, there are morbidity and mortality associated with both. In this paper, we have discussed the efficacy an...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/869214

    authors: Iqbal S,Friedel DM,Grendell JH,Stavropoulos SN

    更新日期:2013-01-01 00:00:00

  • Peripheral signals mediate the beneficial effects of gastric surgery in obesity.

    abstract::Obesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the modifications in th...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/560938

    authors: Barja-Fernández S,Folgueira C,Castelao C,Leis R,Casanueva FF,Seoane LM

    更新日期:2015-01-01 00:00:00

  • Optimization of Deep Sedation with Spontaneous Respiration for Therapeutic Endoscopy Combining Propofol and Bispectral Index Monitoring.

    abstract::Background/Aims. This study aimed to establish optimal propofol anesthesia for therapeutic endoscopy, which has not been established. Methodology. We retrospectively investigated data on 89 patients who underwent upper-GI endoscopic submucosal dissection or endoscopic mucosal resection under anesthesia with propofol. ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/282149

    authors: Matsumoto K,Nagahara A,Matsumoto K,Akazawa Y,Komori H,Nakagawa Y,Takeda T,Ueyama H,Shimada Y,Asaoka D,Hojo M,Watanabe S

    更新日期:2015-01-01 00:00:00

  • Nutrition care for patients with weight regain after bariatric surgery.

    abstract::Achieving optimal weight outcomes for patients with obesity is important to the management of their chronic disease. All interventions present risks for weight regain. Bariatric surgery is the most efficacious treatment, producing greater weight losses that are sustained over more time compared to lifestyle interventi...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2013/256145

    authors: Johnson Stoklossa C,Atwal S

    更新日期:2013-01-01 00:00:00

  • Influence of gastrectomy on cortical and cancellous bones in rats.

    abstract::The aim of the present study was to examine the influence of gastrectomy (GX) on cortical and cancellous bones in rats. Twenty male Sprague-Dawley rats were randomized into the two groups of 10 animals each: a sham operation (control) group and a GX group. Seven weeks after surgery, the bone mineral content and densit...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,收录出版

    doi:10.1155/2013/381616

    authors: Iwamoto J,Sato Y,Matsumoto H

    更新日期:2013-01-01 00:00:00

  • Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome.

    abstract::Background and Aims. Although the differential expression of microRNA (miRNA) genes has been identified in many diseases, little information exists concerning the miRNA expression profile in type 2 diabetes mellitus (T2DM) with diarrhea-predominant irritable bowel syndrome (D-IBS). Therefore, the specific expression o...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/9256209

    authors: Tao W,Dong X,Kong G,Fang P,Huang X,Bo P

    更新日期:2016-01-01 00:00:00

  • Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional Study.

    abstract::Background and Aims. A retrospective cross-sectional study was conducted to evaluate the role of hyaluronic acid (HA), laminin (LN), amino-terminal propeptide of type III procollagen (PIIINP), and collagen IV (CIV) in predicting the presence of gastroesophageal varices (GEVs) in patients with liver cirrhosis. Methods....

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/274534

    authors: Qi X,Li H,Chen J,Xia C,Peng Y,Dai J,Hou Y,Deng H,Li J,Guo X

    更新日期:2015-01-01 00:00:00

  • Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists.

    abstract:Background:The aim of this study was to evaluate the interobserver variability in diagnosing inflammatory bowel disease (IBD)-associated neoplasia among practicing pathologists from China using telepathology, a practice of remote diagnostic consultation increasingly used nationally and internationally, and its comparis...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/8715263

    authors: Wu XR,Liu HS,Shi XY,Zhou WX,Jiang ZN,Huang Y,Karamchandani DM,Goldblum JR,Xiao SY,Zhu HF,Feely MM,Collinsworth AL,Esnakula A,Xie H,Shen B,Lan P,Liu XL

    更新日期:2018-04-23 00:00:00

  • Radiofrequency Energy in Hepatic Bed during Partial Cystectomy for Hydatid Liver Disease: Standing Out from the Usual Conservative Surgical Management.

    abstract::Background. Surgical treatment of hydatid liver disease (HLD) is divided into conservative and radical procedures. While conservative techniques are easier and faster to perform, there is an emerging need to reduce their morbidity and recurrence rates. Our aim was to present and evaluate the efficiency and safety of t...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/1078653

    authors: Mantonakis E,Papalampros A,Moris D,Dimitrokallis N,Sakarellos P,Griniatsos J,Felekouras E

    更新日期:2016-01-01 00:00:00

  • Minimal Open Access Ileocolic Resection in Complicated Crohn's Disease of the Terminal Ileum.

    abstract::The objective of this study was to evaluate the possibility to undertake an ileocolic resection in complex Crohn's disease using a minimal open abdominal access using standard laparoscopic instruments. The incision was carried out over the previous McBurney scar, with a mean length of 6 cm. Seventy-two patients with c...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/6019435

    authors: Sica GS,Di Carlo S,D'Ugo S,Arcudi C,Siragusa L,Fazzolari L,Biancone L,Monteleone G,Cardi M,Sibio S

    更新日期:2020-02-28 00:00:00

  • Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance.

    abstract::Aims. We here investigated whether the combination of simvastatin and irinotecan could induce the synergistic effect on colon cancer cells with or without resistance to irinotecan. Methods. We investigated cell proliferation assay and assessed cell death detection ELISA and caspase-3 activity assay of various concentr...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/7891374

    authors: Jang HJ,Hong EM,Jang J,Choi JE,Park SW,Byun HW,Koh DH,Choi MH,Kae SH,Lee J

    更新日期:2016-01-01 00:00:00

  • Combined EUS-Guided Abdominal Cavity Drainage and Cystogastrostomy for the Ruptured Pancreatic Pseudocyst.

    abstract::Background. Endoscopic-Ultrasonography- (EUS-) guided puncture and drainage of pancreatic pseudocyst is currently one of the most widely accepted nonsurgical treatments. To date, this technique has only been used for pancreatic pseudocysts adhesive to the gastric wall. This study introduces the technique of EUS-guided...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/785483

    authors: Nan G,Siyu S,Xiang L,Sheng W,Guoxin W

    更新日期:2013-01-01 00:00:00

  • Adjuvant Second-Dose Chemotherapy before Surgery for Patients with Locally Advanced Rectal Malignancy Is Not Beneficial: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Preoperative chemoradiotherapy is the standard treatment for patients with locally advanced rectal cancer, although tumor responses vary widely; some patients may achieve a pathologic complete response rate (pCR) after chemoradiotherapy. Controversy exists with regard to the efficacy of different preoperativ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/1373092

    authors: Chen M,Song X,Chen LZ,Xu L,Lu YP,Zhang JS

    更新日期:2017-01-01 00:00:00

  • Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats.

    abstract::Background. Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/3126280

    authors: Dembiński A,Warzecha Z,Ceranowicz P,Dembiński M,Cieszkowski J,Gosiewski T,Bulanda M,Kuśnierz-Cabala B,Gałązka K,Konturek PC

    更新日期:2016-01-01 00:00:00

  • The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease.

    abstract:Objectives:The aims of this study were to evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers, and parameters from the complete blood count (CBC) in patients with inflammatory bowel disease (IBD) and their associations with disease activity. Methods:A total of 876 IBD patients, composed of 27...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/3467419

    authors: Chen YH,Wang L,Feng SY,Cai WM,Chen XF,Huang ZM

    更新日期:2020-06-22 00:00:00

  • Bifidobacterium animalis ssp. lactis 420 Protects against Indomethacin-Induced Gastric Permeability in Rats.

    abstract::Gastrointestinal (GI) adverse effects such as erosion and increased permeability are common during the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Our objective was to assess whether Bifidobacterium animalis ssp. lactis 420 protects against NSAID-induced GI side effects in a rat model. A total of 120 male Wi...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/615051

    authors: Lyra A,Saarinen M,Putaala H,Olli K,Lahtinen SJ,Ouwehand AC,Madetoja M,Tiihonen K

    更新日期:2012-01-01 00:00:00