Abstract:
Background:Environmental factors and genetic mutations have been increasingly recognized as risk factors for chronic pancreatitis (CP). The PRSS1 p.R122H mutation was the first discovered to affect hereditary CP, with 80% penetrance. We performed here a systematic review and meta-analysis to evaluate the associations of PRSS1 p.R122H mutation with CP of diverse etiology. Methods:The PubMed, EMBASE, and MEDLINE database were reviewed. The pooled odds ratio (OR) with 95% confidence intervals was used to evaluate the association of p.R122H mutation with CP. Initial analysis was conducted with all etiologies of CP, followed by a subgroup analysis for hereditary and nonhereditary CP, including alcoholic or idiopathic CP. Results:A total of eight case-control studies (1733 cases and 2415 controls) were identified and included. Overall, PRSS1 p.R122H mutation was significantly associated with an increased risk of CP (OR = 4.78[1.13-20.20]). Further analysis showed p.R122H mutation strongly associated with the increased risk of hereditary CP (OR = 65.52[9.09-472.48]) but not with nonhereditary CP, both alcoholic and idiopathic CP. Conclusions:Our study showing the differential role of p.R122H mutation in various etiologies of CP indicates that this complex disorder is likely influenced by multiple genetic factors as well as environmental factors.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Hu C,Wen L,Deng L,Zhang C,Lugea A,Su HY,Waldron RT,Pandol SJ,Xia Qdoi
10.1155/2017/9505460subject
Has Abstractpub_date
2017-01-01 00:00:00pages
9505460eissn
1687-6121issn
1687-630Xjournal_volume
2017pub_type
杂志文章,评审abstract:Background:Our aim was to assess the risk of gastrointestinal (GI) hemorrhage associated with diabetes among patients taking low-dose aspirin (≤325 mg/day). Methods:A systematic search was conducted for publication in English and Chinese using term equivalents for "GI hemorrhage", "aspirin", and "diabetes mellitus" up...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2020/9824615
更新日期:2020-08-03 00:00:00
abstract::Purpose. By examining the prescribing patterns and inappropriate use of acid suppressive therapy (AST) during hospitalization and at discharge we sought to identify the risk factors associated with such practices. Methods. In this retrospective observational study, inpatient records were reviewed from January 2011 to ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/1973086
更新日期:2016-01-01 00:00:00
abstract::Acute renal impairment is common in patients with chronic liver disease, occurring in approximately 19% of hospitalised patients with cirrhosis. A variety of types of renal impairment are recognised. The most important of these is the hepatorenal syndrome, a functional renal impairment due to circulatory and neurohorm...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/207012
更新日期:2015-01-01 00:00:00
abstract:Background:Both long-term proton pump inhibitor use and surgical fundoplication have potential drawbacks as treatments for chronic gastroesophageal reflux disease (GERD). Our aim was to investigate the potential efficacy of antireflux mucosectomy (ARMS) in porcine and determine the optimal circumference of resection in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3286738
更新日期:2019-02-24 00:00:00
abstract::Introduction. Preoperative malnutrition is a major risk factor for increased postoperative morbidity and mortality. Definition and diagnosis of malnutrition and its treatment is still subject for controversy. Furthermore, practical implementation of nutrition-related guidelines is unknown. Methods. A review of the ava...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2011/739347
更新日期:2011-01-01 00:00:00
abstract:Aim:To describe the abnormalities at MR imaging and related complaints in patients with poor outcome after STARR procedure. Materials and Methods:The medical records of 21 symptomatic patients from centre 1, 31 patients from centre 2, and 63 patients from centre 3 were reviewed with regard to findings at MR defecograp...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/4392918
更新日期:2017-01-01 00:00:00
abstract:Background/Aims:The damage of interstitial cells of Cajal and smooth muscle cells has far-reaching implications in the pathogenesis of gastroparesis in diabetic patients. Gastric electrical stimulation (GES) is an efficient therapy for gastric motility disorders, but the mechanisms of GES require clarification. Method...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/6309157
更新日期:2018-11-13 00:00:00
abstract::The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Rece...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/761060
更新日期:2013-01-01 00:00:00
abstract::Introduction. The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC). Material and Methods. The serum levels of study factors were measured in 73 patients with CRC and in 35 ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/146819
更新日期:2015-01-01 00:00:00
abstract::High throughput methodologies have revealed the existence of an unexpectedly large number of long noncoding RNAs (lncRNAs). The unconventional role of lncRNAs in gene expression regulation and their broad implication in oncogenic and tumor suppressive pathways have introduced lncRNAs as novel biological tumor markers....
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/319861
更新日期:2015-01-01 00:00:00
abstract::Background and Aims. The study was a repeated evaluation of the experience of capsule endoscopy (CE) in patients with cardiac pacemaker or implantable cardioverter defibrillator (ICD). Patients and Methods. A standardized questionnaire was sent by the manufactors Given Imaging and Olympus to all centers in Germany, Au...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/717408
更新日期:2012-01-01 00:00:00
abstract:BACKGROUNDS:Magnifying endoscopy with blue laser imaging (ME-BLI) for diagnosis of early gastric cancer (EGC) is as effective as magnifying endoscopy with narrow-band imaging (ME-NBI). However, there are different EGCs in microstructure visualization between ME-BLI and ME-NBI. This study aimed to clarify the pathologic...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8303046
更新日期:2017-01-01 00:00:00
abstract::Background. Endoscopic-Ultrasonography- (EUS-) guided puncture and drainage of pancreatic pseudocyst is currently one of the most widely accepted nonsurgical treatments. To date, this technique has only been used for pancreatic pseudocysts adhesive to the gastric wall. This study introduces the technique of EUS-guided...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/785483
更新日期:2013-01-01 00:00:00
abstract::The most common cause of chronic pancreatitis (CP) is alcohol abuse. The aim of the present study was to identify patients with genetic predisposition to CP abusing alcohol. The question posed was whether CP manifests at a younger age and diabetes mellitus develops earlier in individuals with genetic predisposition. T...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/309156
更新日期:2015-01-01 00:00:00
abstract::Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus b...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/8180323
更新日期:2020-11-28 00:00:00
abstract::This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder. The lithogenic diet caused elevation of triglycerides, cholesterol, and low-density...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/1343969
更新日期:2020-04-21 00:00:00
abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/4946068
更新日期:2017-01-01 00:00:00
abstract::Objective. Here, we aim to investigate the microRNA (miR) profiling in human gastric cancer (GC). Methods. Tumoral and matched peritumoral gastric specimens were collected from 12 GC patients who underwent routine surgery. A high-throughput miR sequencing method was applied to detect the aberrantly expressed miRs in a...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1526981
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to establish a retrospective evaluation and comparison of the hydrogen/methane (H2/CH4) breath test and genetic test (C/T-13910 polymorphism) results in lactose malabsorption testing. In total 263 consecutive patients with suspected lactose malabsorption were included in this study. They unde...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/464382
更新日期:2014-01-01 00:00:00
abstract:Objective:Recurrence after curative resection for hepatocellular carcinoma (HCC) is a major cause of death from this disease. Factors of primary curative resection are available and potential in the prognosis of follow-up treatment. Our aim was to assess the prognostic significance of primary curative resection factors...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2021/8878417
更新日期:2021-01-02 00:00:00
abstract::Reorganization of the actin cytoskeleton underlies cell migration in a wide variety of physiological and pathological processes, such as embryonic development, wound healing, and tumor cell invasion. It has been shown that actin assembly and disassembly are precisely regulated by intracellular signaling cascades that ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/930157
更新日期:2015-01-01 00:00:00
abstract::Medicinal plants and probiotics both have very high potential in terms of their antimicrobial activity against antibiotic-resistant enteric pathogens. The probiotics being enteric microorganism do not have any parasitic effect on human beings. They have been an integral part of daily food for centuries. They have been...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/457150
更新日期:2012-01-01 00:00:00
abstract:Background and Aims:To date, there are no validated measures in IBD to assess the level of preparedness for transition into adult health care. The purpose of this study was to develop and assess the reliability and validity of a "Transition Readiness" (TR) measure for adolescents with IBD, as well as to evaluate the le...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5062105
更新日期:2019-06-18 00:00:00
abstract::Common bile duct stones (CBDSs) may occur in up to 3%-14.7% of all patients for whom cholecystectomy is preformed. Patients presenting with CBDS have symptoms including: biliary colic, jaundice, cholangitis, pancreatitis or may be asymptomatic. It is important to distinguish between primary and secondary stones, becau...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2009/840208
更新日期:2009-01-01 00:00:00
abstract::Obesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the modifications in th...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/560938
更新日期:2015-01-01 00:00:00
abstract::The incidence of inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), has increased in pediatric populations over the last decade. Patients diagnosed during childhood often survive well into adulthood, and therefore their healthcare requires transfer to an adult gastroenterolo...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/853530
更新日期:2015-01-01 00:00:00
abstract::Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (12f : 12m, 22-29 ye...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/424503
更新日期:2014-01-01 00:00:00
abstract::We explain the state of the art of the immunohistochemical markers of response in rectal cancers treated with neoadjuvant medical therapies and its implication with prognosis. Neoadjuvant chemoradiotherapy is widely used to improve the outcome of patients with locally advanced rectal cancer, and the evaluation of the ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/2808235
更新日期:2017-01-01 00:00:00
abstract::Background. An increasing resistance of Helicobacter pylori strains to antimicrobial agents is the serious therapeutic problem. The aim of this study was to compare the primary and secondary resistance of H. pylori strains isolated between 2006-2008 (data published) and 2009-2011 to clarithromycin and levofloxacin. Ma...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/418010
更新日期:2012-01-01 00:00:00
abstract::Myeloproliferative neoplasms (MPNs) are the leading cause of Budd-Chiari syndrome (BCS), and the C allele of JAK2 rs4495487 was reported to be an additional candidate locus that contributed to MPNs. In the present study, we examined the role of JAK2 rs4495487 in the etiology and clinical presentation of Chinese BCS pa...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/807865
更新日期:2015-01-01 00:00:00