Abstract:
Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and Wanfang Data through March 1, 2018, with no limits. Two investigators independently screened all retrieved studies. The investigators of the original publications were contacted if required information was absent. All the included studies were managed by EndNote X7. Quality assessment of the included studies was performed using a modified Newcastle-Ottawa Scale judgment. Extracted data for each endpoint were analyzed by using STATA 12.0 software. Results:Thirteen studies, including a total of 1468 patients, comparing the effects of HS with HA were pooled in this meta-analysis. Outcomes including postoperative complications, perioperative mortality, intraoperative blood transfusion, and albumin (ALB) content at postoperation day (POD) 7 did not differ significantly between the two groups. Simultaneous approaches significantly promoted 1-, 3-, and 5-year disease-free survival (DFS) rates and overall survival (OS) rates, prolonged operation time, aggravated intraoperative blood loss, increased white blood cell (WBC) and platelet (PLT) counts at POD 7, and lowered total bilirubin (T-Bil) contents at POD 1 and 7. Conclusion:Compared to HA, HS is safer and more effective in ameliorating liver function and improving survival of HCC patients complicated with hypersplenism. This trial is registered with CRD42018093779.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Liu X,Chen Z,Yu M,Zhou W,Zhi X,Li Tdoi
10.1155/2019/9065845subject
Has Abstractpub_date
2019-08-14 00:00:00pages
9065845eissn
1687-6121issn
1687-630Xjournal_volume
2019pub_type
杂志文章,评审abstract::Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/398585
更新日期:2015-01-01 00:00:00
abstract:Background:Our aim was to assess the risk of gastrointestinal (GI) hemorrhage associated with diabetes among patients taking low-dose aspirin (≤325 mg/day). Methods:A systematic search was conducted for publication in English and Chinese using term equivalents for "GI hemorrhage", "aspirin", and "diabetes mellitus" up...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2020/9824615
更新日期:2020-08-03 00:00:00
abstract:Background:Prokinetic agents are used in diabetic gastroparesis patients to improve gastric emptying and upper gastrointestinal (GI) symptoms. However, the efficacy of prokinetic agents against glycemic control is questionable. Therefore, we conducted a systemic review and meta-analysis to determine the efficacy of pro...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/3014973
更新日期:2019-09-09 00:00:00
abstract::Caustic esophageal stricture (CES) in children still occurs frequently in developing countries. We aimed to evaluate the long-term outcomes of endoscopic balloon dilatation (EBD) in treating CES in children and the influencing factors associated with outcome. We retrospectively reviewed the data of all patients who ha...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/8352756
更新日期:2018-08-08 00:00:00
abstract::Background and Aims. Studies have shown effects of diet on gut microbiota. We aimed to identify foods associated with recurrent Clostridium difficile infection (CDI). Methods. In this cross-sectional survey, consecutive patients diagnosed with CDI were identified by electronic medical records. Colitis symptoms and pos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/4514687
更新日期:2016-01-01 00:00:00
abstract::Although the thread-traction (TT) method has been found useful during endoscopic submucosal dissection (ESD) for early gastric cancers, the movement of the thread interferes with the movement of the endoscope, and the lesion can only be pulled to the mouth side. We have developed the novel TT method using a sheath of ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/9415497
更新日期:2016-01-01 00:00:00
abstract::Background/Aims. This study aimed to establish optimal propofol anesthesia for therapeutic endoscopy, which has not been established. Methodology. We retrospectively investigated data on 89 patients who underwent upper-GI endoscopic submucosal dissection or endoscopic mucosal resection under anesthesia with propofol. ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/282149
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To investigate the differences in the results of esophageal function tests for functional heartburn (FH) and reflux hypersensitivity (RH). METHODS:Patients with FH and RH and healthy volunteers (HVs) from the Department of Gastroenterology, Beijing Anzhen Hospital and Beijing Chao-Yang hospital, who underwen...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/3596148
更新日期:2017-01-01 00:00:00
abstract::Background. There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods. A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/2952635
更新日期:2016-01-01 00:00:00
abstract:Aims:To evaluate the impact of body mass index (BMI) on the surgical outcome of laparoscopic total mesorectal excision (laTME) for locally advanced rectal cancer (LARC, clinically staged as UICC stage II/III) after neoadjuvant chemoradiotherapy (nCRT). Methods:312 LARC patients undergoing laTME after nCRT were divided...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1509140
更新日期:2017-01-01 00:00:00
abstract::Autophagy is a catabolic process by which a cell degrades its intracellular materials to replenish itself. Induction of autophagy under various cellular stress stimuli can lead to either cell survival or cell death via apoptotic and/or autophagic (nonapoptotic) pathways. The NSAID sulindac sulfide induces apoptosis in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/897678
更新日期:2012-01-01 00:00:00
abstract::Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology. Recently, mucosal healing has emerged as an important therapeutic endpoint in UC. Linked color imaging (LCI) is a novel endoscopic system that enhances the color differences of the gastrointestinal mucosa. Our previous study emphasi...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3108690
更新日期:2020-03-06 00:00:00
abstract::Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis m...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/979506
更新日期:2012-01-01 00:00:00
abstract::Background and Aim. EUS-guided intervention (EGI) for biliary therapy has been increasingly used in recent years. This report aims to describe the spectrum and experience of EUS-guided interventions in biliary diseases in a single-tertiary center. Methods. All patients with EGI were analyzed retrospectively by retriev...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/680753
更新日期:2012-01-01 00:00:00
abstract::Background. Traditionally, rectal cancer surgery is recommended 6 to 8 weeks after completing neoadjuvant chemoradiation. Extending the waiting time may increase the tumor response rate. However, the perioperative complication rate may increase. The purpose of this study was to determine the association between extend...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/7870815
更新日期:2016-01-01 00:00:00
abstract::Background. There is increasing evidence suggesting that the laparoscopic technique is the treatment of choice for large bowel resection, including for malignancy. The purpose of the study was to assess whether general surgeons, with particular skills in advanced laparoscopy, can adequately provide safe laparoscopic c...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/581523
更新日期:2014-01-01 00:00:00
abstract:Background:The aim of this study was to evaluate the risk of development of colorectal adenomas in patients with colorectal cancer (CRC) with and without colonic diverticulosis. Methods:We performed a retrospective cohort study that included patients with CRC between 2008 and 2011. All patients underwent preoperative ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/8901026
更新日期:2019-05-20 00:00:00
abstract::Background. Endoscopic-Ultrasonography- (EUS-) guided puncture and drainage of pancreatic pseudocyst is currently one of the most widely accepted nonsurgical treatments. To date, this technique has only been used for pancreatic pseudocysts adhesive to the gastric wall. This study introduces the technique of EUS-guided...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/785483
更新日期:2013-01-01 00:00:00
abstract:Aim:This study is aimed at comparing gastric cancer T and N staging between virtual monochromatic energy images and fusion images generated by dual-source computed tomography (DSCT) dual-energy mode data acquisition prospectively while measuring the iodine concentration of gastric cancer and lymph nodes at different T ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/5015202
更新日期:2018-12-04 00:00:00
abstract::The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Rece...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/761060
更新日期:2013-01-01 00:00:00
abstract::Colon cancer is a serious health problem, and novel preventive and therapeutical avenues are urgently called for. Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. Interestingly, bone morphogenetic pr...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/895462
更新日期:2012-01-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a chronic cholestatic liver condition characterized by the immune-mediated damage of the intrahepatic bile ducts. Polymorphisms of vitamin D receptor (VDR) are considered to contribute to its pathogenesis however their incidence varies in different populations and their potential ass...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/408723
更新日期:2012-01-01 00:00:00
abstract::Objective. Here, we aim to investigate the microRNA (miR) profiling in human gastric cancer (GC). Methods. Tumoral and matched peritumoral gastric specimens were collected from 12 GC patients who underwent routine surgery. A high-throughput miR sequencing method was applied to detect the aberrantly expressed miRs in a...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1526981
更新日期:2017-01-01 00:00:00
abstract::Background. Little data on directly comparing chemoradiotherapy with observation has yet been published in the setting of adjuvant therapy for resected gastric cancer who underwent D2 lymphadenectomy. The present indirect comparison aims to provide more evidence on comparing the two approaches. Methods. We conducted a...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/634929
更新日期:2013-01-01 00:00:00
abstract::Aim. To evaluate the feasibility of percutaneous sclerotherapy of symptomatic simple abdominal cysts, using hypertonic saline and bleomycin, as an alternative to surgery. Materials and Methods. This study involved fourteen consecutive patients (ten women, four men, mean age: 59.2 y) with nineteen symptomatic simple cy...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/489363
更新日期:2015-01-01 00:00:00
abstract::Hilar cholangiocarcinoma (HCCA) involves a complex anatomical region where bile ducts, arteries, and veins create a complex network. HCCA can lead to biliary strictures at the main hepatic confluence, involving the right and left radicles. Endoscopic drainage of jaundiced patients with HCCA is challenging and carries ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/5161350
更新日期:2019-11-04 00:00:00
abstract::Endoscopic retrograde cholangiopancreatography (ERCP) can fail in 3-10% of the cases even in experienced hands. Although percutaneous transhepatic cholangiography (PTC) and surgery are the traditional alternatives, there are morbidity and mortality associated with both. In this paper, we have discussed the efficacy an...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/869214
更新日期:2013-01-01 00:00:00
abstract::Background and Aims. Although the differential expression of microRNA (miRNA) genes has been identified in many diseases, little information exists concerning the miRNA expression profile in type 2 diabetes mellitus (T2DM) with diarrhea-predominant irritable bowel syndrome (D-IBS). Therefore, the specific expression o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/9256209
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS. Sixteen newborn rats were randomized into an IBS model group and a control group. Those in the IBS group were separated fr...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/473846
更新日期:2014-01-01 00:00:00
abstract:Objective:Recurrence after curative resection for hepatocellular carcinoma (HCC) is a major cause of death from this disease. Factors of primary curative resection are available and potential in the prognosis of follow-up treatment. Our aim was to assess the prognostic significance of primary curative resection factors...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2021/8878417
更新日期:2021-01-02 00:00:00