Abstract:
Objectives:The incidence of gastrointestinal stromal tumors (GISTs) located in the colon is rare. Current studies mainly focus on case reports for colonic GISTs. Therefore, a population-based analysis was useful to guide the clinical treatment strategy. Methods:The patients were selected from 2000 to 2015 based on Surveillance, Epidemiology, and End Results (SEER) database. Patients' demographics, tumor characteristics, incidence, treatment, and survival were retrieved for analysis. Results:249 cases of colonic GISTs were collected. The male-female ratio was close to 1 : 1 (male 51.41%, female 48.59%). Most cases were Caucasians (70.28%), and African Americans accounted for 19.68%. Age of diagnosis ranged from 21 to 93 years with a median (mean) age of 67.5 (65.56). The incidence was rare, only 0.018 per 100,000. It had an annual percentage change (APC = -0.7728) without statistical significance (P = 0.5127) while the incidence of other GISTs increased from 2000 to 2015, with an annual percentage change of 3.9% (P = 0.0001). Surgery was associated with better prognosis whereas chemotherapy did not impact the survival rate. Conclusion:Colonic GIST is a rare solid tumor, and the incidence is stable. The entity has a poorer prognosis than other GISTs. Surgery improved the survival rate, while chemotherapy did not.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Liu Z,Sun Y,Li Y,Zhao J,Wu S,Meng Z,Wu Hdoi
10.1155/2019/3849850subject
Has Abstractpub_date
2019-04-11 00:00:00pages
3849850eissn
1687-6121issn
1687-630Xjournal_volume
2019pub_type
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