Long-Pulse Gastric Electrical Stimulation Repairs Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastric Antrum of Diabetic Rats.

Abstract:

Background/Aims:The damage of interstitial cells of Cajal and smooth muscle cells has far-reaching implications in the pathogenesis of gastroparesis in diabetic patients. Gastric electrical stimulation (GES) is an efficient therapy for gastric motility disorders, but the mechanisms of GES require clarification. Methods:Male rats were randomly divided into the control group, diabetic rat group (DM), diabetic rats with sham GES group (DM + SGES), and diabetic rats with different frequency GES group (DM + GES) (GES1: 5.5 cpm, 100 ms, 4 mA; GES2: 5.5 cpm, 300 ms, 4 mA; and GES3: 5.5 cpm, 550 ms, 2 mA). Gastric contractions were explored using the organ bath technique. The alterations of interstitial cells of Cajal, the SCF/c-kit pathway, and smooth muscle cells were also investigated. Results:(1) Gastric contractions were significantly improved in the DM + GES group compared with those in the DM group. (2) The damage of interstitial cells of Cajal was prevented in the DM + GES group in contrast to the DM group. Moreover, long-pulse GES increased the expression of the SCF/c-kit pathway. More proliferated interstitial cells of Cajal in muscle layers were observed obviously in the DM + GES group. (3) The number of smooth muscle cells in the DM group was not significantly decreased compared with that in the control group. However, ultrastructural changes were distinctly damaged in the DM group. The application of GES protected against the alteration of the ultrastructures of smooth muscle cells. Conclusions:Long-pulse GES improves gastric contraction possibly by enhancing the proliferation of interstitial cells of Cajal and restoring the injury of smooth muscle cells.

authors

Chen Y,Wang H,Li H,Liu S

doi

10.1155/2018/6309157

subject

Has Abstract

pub_date

2018-11-13 00:00:00

pages

6309157

eissn

1687-6121

issn

1687-630X

journal_volume

2018

pub_type

杂志文章
  • Colorectal Malignancy in a Prospective Irish Inflammatory Bowel Disease Population 15 Years Since Diagnosis: Comparison with the EC-IBD Cohort.

    abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/4946068

    authors: Shuhaibar M,O'Morain C

    更新日期:2017-01-01 00:00:00

  • Retracted: Influence of Gastrectomy on Cortical and Cancellous Bones in Rats.

    abstract::[This retracts the article DOI: 10.1155/2013/381616.]. ...

    journal_title:Gastroenterology research and practice

    pub_type: 撤回出版物

    doi:10.1155/2020/5109831

    authors: Research And Practice G

    更新日期:2020-10-31 00:00:00

  • The Differential Role of Human Cationic Trypsinogen (PRSS1) p.R122H Mutation in Hereditary and Nonhereditary Chronic Pancreatitis: A Systematic Review and Meta-Analysis.

    abstract:Background:Environmental factors and genetic mutations have been increasingly recognized as risk factors for chronic pancreatitis (CP). The PRSS1 p.R122H mutation was the first discovered to affect hereditary CP, with 80% penetrance. We performed here a systematic review and meta-analysis to evaluate the associations o...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/9505460

    authors: Hu C,Wen L,Deng L,Zhang C,Lugea A,Su HY,Waldron RT,Pandol SJ,Xia Q

    更新日期:2017-01-01 00:00:00

  • Face-to-Face Cognitive-Behavioral Therapy for Irritable Bowel Syndrome: The Effects on Gastrointestinal and Psychiatric Symptoms.

    abstract::Irritable bowel syndrome (IBS) is a gastrointestinal disorder linked to disturbances in the gut-brain axis. Visceral hypersensitivity and pain are hallmarks of IBS and linked to the physiological and psychological burden and to the nonadaptive coping with stress. Cognitive-behavioral therapy (CBT) for IBS has proven e...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/8915872

    authors: Edebol-Carlman H,Ljótsson B,Linton SJ,Boersma K,Schrooten M,Repsilber D,Brummer RJ

    更新日期:2017-01-01 00:00:00

  • Identifying Risk Factors Associated with Inappropriate Use of Acid Suppressive Therapy at a Community Hospital.

    abstract::Purpose. By examining the prescribing patterns and inappropriate use of acid suppressive therapy (AST) during hospitalization and at discharge we sought to identify the risk factors associated with such practices. Methods. In this retrospective observational study, inpatient records were reviewed from January 2011 to ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/1973086

    authors: Singh A,Bodukam V,Saigal K,Bahl J,Wang Y,Hanlon A,Lu Y,Davis M

    更新日期:2016-01-01 00:00:00

  • Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility.

    abstract::Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconcl...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/764163

    authors: Ni Q,Ji A,Yin J,Wang X,Liu X

    更新日期:2015-01-01 00:00:00

  • Tea and Recurrent Clostridium difficile Infection.

    abstract::Background and Aims. Studies have shown effects of diet on gut microbiota. We aimed to identify foods associated with recurrent Clostridium difficile infection (CDI). Methods. In this cross-sectional survey, consecutive patients diagnosed with CDI were identified by electronic medical records. Colitis symptoms and pos...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/4514687

    authors: Oman Evans Ii M,Starley B,Galagan JC,Yabes JM,Evans S,Salama JJ

    更新日期:2016-01-01 00:00:00

  • Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis.

    abstract::Autophagy is a catabolic process by which a cell degrades its intracellular materials to replenish itself. Induction of autophagy under various cellular stress stimuli can lead to either cell survival or cell death via apoptotic and/or autophagic (nonapoptotic) pathways. The NSAID sulindac sulfide induces apoptosis in...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/897678

    authors: Chiou SK,Hoa N,Ge L,Jadus MR

    更新日期:2012-01-01 00:00:00

  • Perioperative nutrition in abdominal surgery: recommendations and reality.

    abstract::Introduction. Preoperative malnutrition is a major risk factor for increased postoperative morbidity and mortality. Definition and diagnosis of malnutrition and its treatment is still subject for controversy. Furthermore, practical implementation of nutrition-related guidelines is unknown. Methods. A review of the ava...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2011/739347

    authors: Cerantola Y,Grass F,Cristaudi A,Demartines N,Schäfer M,Hübner M

    更新日期:2011-01-01 00:00:00

  • Impact of Body Mass Index on Surgical and Oncological Outcomes in Laparoscopic Total Mesorectal Excision for Locally Advanced Rectal Cancer after Neoadjuvant 5-Fluorouracil-Based Chemoradiotherapy.

    abstract:Aims:To evaluate the impact of body mass index (BMI) on the surgical outcome of laparoscopic total mesorectal excision (laTME) for locally advanced rectal cancer (LARC, clinically staged as UICC stage II/III) after neoadjuvant chemoradiotherapy (nCRT). Methods:312 LARC patients undergoing laTME after nCRT were divided...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/1509140

    authors: Sun Y,Chi P

    更新日期:2017-01-01 00:00:00

  • Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis.

    abstract:Background:Tumor regression grade (TRG) is widely used in gastrointestinal carcinoma to evaluate pathological responses to neoadjuvant chemotherapy (NCT), but whether it is an independent prognostic factor is still controversial. The aim of this study is to investigate the value of TRG in locally advanced gastric adeno...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/3435673

    authors: Tong Y,Zhu Y,Zhao Y,Shan Z,Zhang J,Liu D

    更新日期:2020-07-18 00:00:00

  • Psychological issues in inflammatory bowel disease: an overview.

    abstract::Inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) is a chronic and disabling disease with unknown etiology. There have been some controversies regarding the role of psychological factors in the course of IBD. The purpose of this paper is to review that role. First the evidence...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/106502

    authors: Sajadinejad MS,Asgari K,Molavi H,Kalantari M,Adibi P

    更新日期:2012-01-01 00:00:00

  • Clinical Outcomes and Safety of Partial Full-Thickness Myotomy versus Circular Muscle Myotomy in Peroral Endoscopic Myotomy for Achalasia Patients.

    abstract::Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/2676513

    authors: Li C,Gong A,Zhang J,Duan Z,Ge L,Xia N,Leng J,Li M,Liu Y

    更新日期:2017-01-01 00:00:00

  • Clinical outcome of patients with complete pathological response to neoadjuvant chemoradiotherapy for locally advanced rectal cancers: the Indian scenario.

    abstract::Introduction. Neoadjuvant chemoradiotherapy and total mesorectal excision are considered the standard treatment for locally advanced rectal cancer. Various studies have reported pathological downstaging and a complete pathological response rate of 15%-27% following neoadjuvant chemoradiotherapy which has translated in...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/867841

    authors: Sinukumar S,Patil P,Engineer R,Desouza A,Saklani A

    更新日期:2014-01-01 00:00:00

  • Magnifying Endoscopy with Blue Laser Imaging Improves the Microstructure Visualization in Early Gastric Cancer: Comparison of Magnifying Endoscopy with Narrow-Band Imaging.

    abstract:BACKGROUNDS:Magnifying endoscopy with blue laser imaging (ME-BLI) for diagnosis of early gastric cancer (EGC) is as effective as magnifying endoscopy with narrow-band imaging (ME-NBI). However, there are different EGCs in microstructure visualization between ME-BLI and ME-NBI. This study aimed to clarify the pathologic...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/8303046

    authors: Kimura-Tsuchiya R,Dohi O,Fujita Y,Yagi N,Majima A,Horii Y,Kitaichi T,Onozawa Y,Suzuki K,Tomie A,Okayama T,Yoshida N,Kamada K,Katada K,Uchiyama K,Ishikawa T,Takagi T,Handa O,Konishi H,Kishimoto M,Naito Y,Yanagisa

    更新日期:2017-01-01 00:00:00

  • Dynamic Detection of Monocyte Subsets in Peripheral Blood of Patients with Acute Hypertriglyceridemic Pancreatitis.

    abstract:Aim:Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocy...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/5705782

    authors: Zheng J,Fan J,Huang C,Lu Y,Huang Z,Wang X,Zeng Y

    更新日期:2019-06-10 00:00:00

  • Correlation between Endosonographic and Doppler Ultrasound Features of Portal Hypertension in Patients with Cirrhosis.

    abstract::Purpose. Endoscopic ultrasound (EUS) permits the detailed visualization of clinically significant features of portal hypertension; however, it is an invasive procedure that is not widely available. The aim of this cross-sectional study was to determine whether a correlation exists between the features of portal hypert...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/395345

    authors: Wiechowska-Kozłowska A,Zasada K,Milkiewicz M,Milkiewicz P

    更新日期:2012-01-01 00:00:00

  • Laparoscopic Appendectomy versus Mini-Incision Appendectomy in Patients with Lower Body Mass Index and Noncomplicated Appendicitis.

    abstract::Laparoscopic appendectomy has become favored over open surgical methods for its association with decreased postoperative pain, more rapid return to daily activities, and improved cosmetic results. Mini-incision appendectomy was being performed in our clinic for a long time especially in patients with noncomplicated ap...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/138648

    authors: Özsan İ,Karabuğa T,Yoldaş Ö,Alpdoğan Ö,Aydın Ü

    更新日期:2014-01-01 00:00:00

  • Desmoplasia in pancreatic cancer. Can we fight it?

    abstract::The hallmark of pancreatic tumours, the desmoplastic reaction, provides a unique microenvironment that affects pancreatic tumour behaviour, its ability to grow and metastasize as well as resist the effects of chemotherapy. Complex molecular interactions and pathways give rise to the desmoplastic reaction. Breakdown or...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/781765

    authors: Merika EE,Syrigos KN,Saif MW

    更新日期:2012-01-01 00:00:00

  • Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats.

    abstract::Background. Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/3126280

    authors: Dembiński A,Warzecha Z,Ceranowicz P,Dembiński M,Cieszkowski J,Gosiewski T,Bulanda M,Kuśnierz-Cabala B,Gałązka K,Konturek PC

    更新日期:2016-01-01 00:00:00

  • Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms.

    abstract::Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5491465

    authors: Li F,Duan K,Wang C,McClain C,Feng W

    更新日期:2016-01-01 00:00:00

  • Lack of Association Found between Helicobacter pylori Infection and Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Retrospective Study.

    abstract::Aims. The association between Helicobacter pylori (H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue. Methods. A total of 502 inpatients with Rome III confirmed IBS-D and known H. pylori status from 8 hos...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/3059201

    authors: Xiong F,Xiong M,Ma Z,Huang S,Li A,Liu S

    更新日期:2016-01-01 00:00:00

  • Thromboelastography in Patients with Inflammatory Bowel Disease.

    abstract:Purpose:Patients with inflammatory bowel disease (IBD) frequently suffer from venous thromboembolic events, and the risk of thromboembolism increases along with disease activity. This study was conducted to discover novel thrombophilic markers using thromboelastography (TEG) and to evaluate the relation between the pre...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/3245657

    authors: Shen Y,Shi L,Zhang J,Zhu H,Yao Y,Liu Z,Zou X,Zhang X

    更新日期:2020-05-20 00:00:00

  • Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer.

    abstract::Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/393015

    authors: Carrasco G,Corvalan AH

    更新日期:2013-01-01 00:00:00

  • Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland.

    abstract::Background. An increasing resistance of Helicobacter pylori strains to antimicrobial agents is the serious therapeutic problem. The aim of this study was to compare the primary and secondary resistance of H. pylori strains isolated between 2006-2008 (data published) and 2009-2011 to clarithromycin and levofloxacin. Ma...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/418010

    authors: Karczewska E,Klesiewicz K,Skiba I,Wojtas-Bonior I,Sito E,Czajecki K,Zwolińska-Wcisło M,Budak A

    更新日期:2012-01-01 00:00:00

  • Recent Advances in NSAIDs-Induced Enteropathy Therapeutics: New Options, New Challenges.

    abstract::The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Rece...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2013/761060

    authors: Lim YJ,Chun HJ

    更新日期:2013-01-01 00:00:00

  • Radiofrequency Energy in Hepatic Bed during Partial Cystectomy for Hydatid Liver Disease: Standing Out from the Usual Conservative Surgical Management.

    abstract::Background. Surgical treatment of hydatid liver disease (HLD) is divided into conservative and radical procedures. While conservative techniques are easier and faster to perform, there is an emerging need to reduce their morbidity and recurrence rates. Our aim was to present and evaluate the efficiency and safety of t...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/1078653

    authors: Mantonakis E,Papalampros A,Moris D,Dimitrokallis N,Sakarellos P,Griniatsos J,Felekouras E

    更新日期:2016-01-01 00:00:00

  • Ileostomy Prolapse in Children with Intestinal Dysmotility.

    abstract:BACKGROUND:A relationship between intestinal motility and ileostomy prolapse has been suggested but not demonstrated objectively. AIMS:This study evaluated the association between ileostomy prolapse and intestinal dysmotility in children. METHODS:IRB-approved retrospective review of 163 patients with ileostomies (199...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/7182429

    authors: Sparks EA,Velazco CS,Fullerton BS,Fisher JG,Khan FA,Hall AM,Jaksic T,Rodriguez L,Modi BP

    更新日期:2017-01-01 00:00:00

  • E. coli-produced BMP-2 as a chemopreventive strategy for colon cancer: a proof-of-concept study.

    abstract::Colon cancer is a serious health problem, and novel preventive and therapeutical avenues are urgently called for. Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. Interestingly, bone morphogenetic pr...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/895462

    authors: Yuvaraj S,Al-Lahham SH,Somasundaram R,Figaroa PA,Peppelenbosch MP,Bos NA

    更新日期:2012-01-01 00:00:00

  • Confocal Laser Endomicroscopy in the Study of Colonic Mucosa in IBD Patients: A Review.

    abstract::Confocal laser endomicroscopy (CLE) is one of several novel methods that provide real-time, high-resolution imaging at a micronscale via endoscopes. CLE and related technologies are often termed "virtual biopsy" as they simulate the images seen in traditional histology. Recently, the use of CLE was reported in the stu...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/525098

    authors: Salvatori F,Siciliano S,Maione F,Esposito D,Masone S,Persico M,De Palma GD

    更新日期:2012-01-01 00:00:00