当前位置： SCI文献检索 > CURRENT OPINION IN CHEMICAL BIOLOGY期刊下所有文献 > Recent progress in photoacoustic molecular imaging.

Recent progress in photoacoustic molecular imaging.

Abstract：

:By acoustically detecting the optical absorption contrast, photoacoustic (PA) tomography (PAT) has broken the penetration limits of traditional high-resolution optical imaging. Through spectroscopic analysis of the target's optical absorption, PAT can identify a wealth of endogenous and exogenous molecules and thus is inherently capable of molecular imaging with high sensitivity. PAT's molecular sensitivity is uniquely accompanied by non-ionizing radiation, high spatial resolution, and deep penetration in biological tissues, which other optical imaging modalities cannot achieve yet. In this concise review, we summarize the most recent technological advancements in PA molecular imaging and highlight the novel molecular probes specifically made for PAT in deep tissues. We conclude with a brief discussion of the opportunities for future advancements.

journal_name

Curr Opin Chem Biol

journal_title

Current opinion in chemical biology

authors

Yao J,Wang LV

doi

10.1016/j.cbpa.2018.03.016

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

104-112

eissn

1367-5931

issn

1879-0402

pii

S1367-5931(18)30008-5

journal_volume

45

pub_type

杂志文章,评审

相关文献

CURRENT OPINION IN CHEMICAL BIOLOGY文献大全
  • Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly.

    abstract：:Rapid progress in genomics and proteomics has provided a wealth of new targets for the pharmaceutical industry, even as many older targets still remain challenging for small-molecule drug discovery. Fragment-based lead discovery, in which leads are built progressively by expanding or combining small fragments, is a ra...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2004.06.010

    authors： Erlanson DA,Hansen SK

    更新日期：2004-08-01 00:00:00

  • Single-stranded DNA repeat synthesis by telomerase.

    abstract：:The eukaryotic ribonucleoprotein reverse transcriptase (RT) telomerase uses a template within its integral RNA subunit to extend chromosome ends by synthesis of single-stranded telomeric repeats. Telomerase is adapted to its unique cellular role by an ability to release product DNA in single-stranded form, regeneratin...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2011.07.011

    authors： Collins K

    更新日期：2011-10-01 00:00:00

  • The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets.

    abstract：:Oligonucleotide in vitro selection provides surprisingly specific aptamers to protein targets. Synthetic chemistries for modifying nucleotides have been developed to enhance aptamer binding affinity. The diversity of nucleosides amenable to either triphosphate synthesis or phosphoramidite activation is now sufficientl...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/s1367-5931(97)80103-2

    authors： Eaton BE

    更新日期：1997-06-01 00:00:00

  • How good is your screening library?

    abstract：:Efficient library design is an ongoing challenge for investigators seeking novel ligands for proteins, whether for drug discovery or chemical biology. Strategies that add neglected chemistry or exclude unproductive compounds are two dominant recent themes, as is a growing awareness of molecular complexity and its impl...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2006.06.003

    authors： Irwin JJ

    更新日期：2006-08-01 00:00:00

  • Sense and sensitivity in bioprocessing-detecting cellular metabolites with biosensors.

    abstract：:Biosensors use biological elements to detect or quantify an analyte of interest. In bioprocessing, biosensors are employed to monitor key metabolites. There are two main types: fully biological systems or biological recognition coupled with physical/chemical detection. New developments in chemical biosensors include m...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2017.05.014

    authors： Dekker L,Polizzi KM

    更新日期：2017-10-01 00:00:00

  • Accessory factor-bZIP-DNA interactions.

    abstract：:DNA binding and transcriptional activation by basic region leucine zipper (bZIP) proteins can be enhanced by accessory factors. In the past year, three accessory factor-bZIP-DNA complexes have been investigated extensively. Experiments have probed the effect of accessory factors on bZIP-DNA specificity, the residues t...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/s1367-5931(98)80031-8

    authors： Baranger AM

    更新日期：1998-02-01 00:00:00

  • High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds.

    abstract：:Combinatorial chemistry methods and high-throughput screening for leads in industrial drug discovery have generated a potential bottleneck in the optimisation processes that seek to align potency with good pharmacokinetics in order to produce good medicines. This has resulted in the need for higher throughput methods ...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章

    doi：10.1016/s1367-5931(98)80017-3

    authors： Tarbit MH,Berman J

    更新日期：1998-06-01 00:00:00

  • The computational prediction of toxicity.

    abstract：:Recent developments in the prediction of toxicity from chemical structure have been reviewed. Attention has been drawn to some of the problems that can be encountered in the area of predictive toxicology, including the need for a multi-disciplinary approach and the need to address mechanisms of action. Progress has be...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/s1367-5931(00)00218-0

    authors： Barratt MD,Rodford RA

    更新日期：2001-08-01 00:00:00

  • Nanoscale controlled self-assembled monolayers and quantum dots.

    abstract：:Self-assembled monolayer (SAM) and fluorescent quantum dots (QDs) share common ground as emerging tools for nanoscale observation of biological interactions. SAMs provide excellent means of controlling the surface characteristics through individually tailored and engineered building blocks. SAMs on various surfaces ha...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2006.08.006

    authors： Shin SK,Yoon HJ,Jung YJ,Park JW

    更新日期：2006-10-01 00:00:00

  • Cross-reactivity in antibody microarrays and multiplexed sandwich assays: shedding light on the dark side of multiplexing.

    abstract：:Immunoassays are indispensable for research and clinical analysis, and following the emergence of the omics paradigm, multiplexing of immunoassays is more needed than ever. Cross-reactivity (CR) in multiplexed immunoassays has been unexpectedly difficult to mitigate, preventing scaling up of multiplexing, limiting ass...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2013.11.012

    authors： Juncker D,Bergeron S,Laforte V,Li H

    更新日期：2014-02-01 00:00:00

  • Nonnatural substrates for polyketide synthases and their associated modifying enzymes.

    abstract：:Polyketides are a large class of structurally diverse, biologically active natural products. Recent experiments add evidence that many of the enzymes involved in the biosynthesis of these natural products are intrinsically tolerant of nonnatural substrates. In addition, an increasing understanding of structure-functio...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/s1367-5931(02)00360-5

    authors： Pohl NL

    更新日期：2002-12-01 00:00:00

  • Vitamin B12 in the spotlight again.

    abstract：:The ability of cobalamin to coordinate different upper axial ligands gives rise to a diversity of reactivity. Traditionally, adenosylcobalamin is associated with radical-based rearrangements, and methylcobalamin with methyl cation transfers. Recently, however, a new role for adenosylcobalamin has been discovered as a ...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2017.01.013

    authors： Bridwell-Rabb J,Drennan CL

    更新日期：2017-04-01 00:00:00

  • Nucleotide analogues to investigate RNA structure and function.

    abstract：:RNA plays an essential cellular role in nearly every aspect of the transmission and expression of genetic information, including regulatory roles that have significance for cellular development. Access to RNA bearing synthetic modifications has allowed biological chemists to probe deep into the inner workings of cellu...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2005.10.009

    authors： Das SR,Fong R,Piccirilli JA

    更新日期：2005-12-01 00:00:00

  • Ribosome-mediated synthesis of natural product-like peptides via cell-free translation.

    abstract：:Peptide natural products (PNPs) represent a unique class of compounds known for their fascinating structural motifs with important biological activities. Lately, PNPs have garnered a lot of interest for their application in drug discovery. Nevertheless, lack of diversity oriented synthetic/biosynthetic platforms to ge...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2016.06.006

    authors： Maini R,Umemoto S,Suga H

    更新日期：2016-10-01 00:00:00

  • Privileged scaffolds for library design and drug discovery.

    abstract：:This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present stat...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2010.02.018

    authors： Welsch ME,Snyder SA,Stockwell BR

    更新日期：2010-06-01 00:00:00

  • Peroxynitrite: reactive, invasive and enigmatic.

    abstract：:The reactive oxygen and nitrogen species superoxide ion, nitric oxide, nitrogen dioxide and peroxynitrite ion all react with biological target molecules. Some of these interactions are carefully orchestrated segments of signal transduction cascades or part of the armamentarium of the immune system, others are patholog...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/S1367-5931(99)80036-2

    authors： Groves JT

    更新日期：1999-04-01 00:00:00

  • Recent advances in lipid separations and structural elucidation using mass spectrometry combined with ion mobility spectrometry, ion-molecule reactions and fragmentation approaches.

    abstract：:Lipids are a vital class of molecules that play important and varied roles in biological processes, however, fully understanding these roles is extremely difficult due to the immense number and diversity of possible lipid species. While recent advances in chromatography and high resolution mass spectrometry have great...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2017.11.009

    authors： Zheng X,Smith RD,Baker ES

    更新日期：2018-02-01 00:00:00

  • Molecular tools for acute spatiotemporal manipulation of signal transduction.

    abstract：:The biochemical activities involved in signal transduction in cells are under tight spatiotemporal regulation. To study the effects of the spatial patterning and temporal dynamics of biochemical activities on downstream signaling, researchers require methods to manipulate signaling pathways acutely and rapidly. In thi...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2016.08.012

    authors： Ross B,Mehta S,Zhang J

    更新日期：2016-10-01 00:00:00

  • Advancing the large-scale CCS database for metabolomics and lipidomics at the machine-learning era.

    abstract：:Metabolomics and lipidomics aim to comprehensively measure the dynamic changes of all metabolites and lipids that are present in biological systems. The use of ion mobility-mass spectrometry (IM-MS) for metabolomics and lipidomics has facilitated the separation and the identification of metabolites and lipids in compl...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2017.10.033

    authors： Zhou Z,Tu J,Zhu ZJ

    更新日期：2018-02-01 00:00:00

  • Protein epitope mimetics as anti-infectives.

    abstract：:There is growing interest in the design of synthetic molecules that mimic the structures and functions of epitopes found on the surface of peptides and proteins. Epitope mimetics can provide valuable tools to probe complex biological processes, as well as interesting leads for drug and vaccine discovery. One applicati...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2011.02.015

    authors： Robinson JA

    更新日期：2011-06-01 00:00:00

  • Following the Ca²⁺ roadmap to photocaged complexes for Zn²⁺ and beyond.

    abstract：:The first photocaged complexes appeared in the mid-1980s specifically to complement the ongoing work studying intracellular Ca(2+) signaling with fluorescent probes. Recently, the field of biological inorganic chemistry has focused increasingly on the homeostasis mechanisms and possible signaling functions of transiti...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2012.11.015

    authors： Gwizdala C,Burdette SC

    更新日期：2013-04-01 00:00:00

  • Epigenetic regulation by endogenous metabolite pharmacology.

    abstract：:Altered metabolite levels can drive epigenetic changes critical to development and disease. However, in many cases the specific protein-metabolite interactions that underlie this process remain enigmatic. In this review, we make the case that this fundamental missing information may be discovered by applying the tools...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2019.02.002

    authors： Kulkarni RA,Montgomery DC,Meier JL

    更新日期：2019-08-01 00:00:00

  • Nucleic acid crystallography: current progress.

    abstract：:Fifty years after the publication of the DNA double helix model by Watson and Crick, new nucleic acid structures keep emerging at an ever-increasing rate. The past three years have brought a flurry of new oligonucleotide structures, including those of a Hoogsteen-paired DNA duplex, Holliday junctions, DNA-drug complex...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2004.09.004

    authors： Egli M

    更新日期：2004-12-01 00:00:00

  • From protein total synthesis to peptide transamidation and metathesis: playing with the reversibility of N,S-acyl or N,Se-acyl migration reactions.

    abstract：:Amide forming reactions are central to the field of peptide and protein synthesis and are considered to be poorly reversible reactions owing to the high stability of peptide bonds. One amide-forming reaction is native chemical ligation (NCL) which is driven by a sulfur to nitrogen acyl migration process from a transie...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2014.09.030

    authors： Melnyk O,Agouridas V

    更新日期：2014-10-01 00:00:00

  • Traceless and multifunctional linkers for the generation of small molecules on solid supports.

    abstract：:Numerous developments in useful linkers are closely related with the advances in solid-phase organic synthesis. These linkers allow facile attachment functionalization and release molecules of interest. Designing a new anchoring group can be essential for synthesis success, especially for small molecules on solid supp...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2004.04.004

    authors： Gil C,Bräse S

    更新日期：2004-06-01 00:00:00

  • Nucleic-acid-templated synthesis as a model system for ancient translation.

    abstract：:The translation of nucleic acids into synthetic structures with expanded functional potential has been the subject of considerable research, with applications including small-molecule and polymer evolution, reaction discovery and sensing. Here, we review properties of nucleic-acid-templated synthesis in the context of...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2004.09.003

    authors： Calderone CT,Liu DR

    更新日期：2004-12-01 00:00:00

  • Zinc sensing for cellular application.

    abstract：:Numerous tools for Zn2+ sensing in living cells have become available in the past three years. Among them, fluorescence imaging using fluorescent sensor molecules has been the most popular approach. Some of these sensor molecules can be used to visualize Zn2+ in living cells. Some of the biological functions of Zn2+ h...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2004.02.007

    authors： Kikuchi K,Komatsu K,Nagano T

    更新日期：2004-04-01 00:00:00

  • Overcoming the energetic limitations of syngas fermentation.

    abstract：:The fermentation of synthesis gas (including carbon monoxide, carbon dioxide, and hydrogen) with anaerobic acetogens is an established biotechnological process that has recently been transferred to a commercial scale. The natural product spectrum of acetogens is natively restricted to acetate, ethanol, and 2,3-butaned...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2017.10.003

    authors： Molitor B,Marcellin E,Angenent LT

    更新日期：2017-12-01 00:00:00

  • Isotope-edited IR spectroscopy for the study of membrane proteins.

    abstract：:Fourier transform infrared (FTIR) spectroscopy has long been a powerful tool for structural analysis of membrane proteins. However, because of difficulties in resolving contributions from individual residues, most of the derived measurements tend to yield average properties for the system under study. Isotope editing,...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2006.08.013

    authors： Arkin IT

    更新日期：2006-10-01 00:00:00

  • All-atom simulations to studying metallodrugs/target interactions.

    abstract：:Metallodrugs are extensively used to treat and diagnose distinct disease types. The unique physical-chemical properties of metal ions offer tantalizing opportunities to tailor effective scaffolds for selectively targeting specific biomolecules. Modern experimental techniques have collected a large body of structural d...

    journal_title：Current opinion in chemical biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbpa.2020.07.005

    authors： Janoš P,Spinello A,Magistrato A

    更新日期：2020-08-08 00:00:00