Abstract:
:Diabetic macular edema is considered the most important factor related to visual impairment in patients with diabetic retinopathy. Together with the use of grid and focal laser photocoagulation, today the intravitreal administration of pharmacotherapies represents the standard of care for the treatment of this complication: anti-vascular endothelium growth factor agents and steroids are the drugs currently used for this aim. Differently from laser therapy, which prevents visual deterioration, the intravitreal approach allows the promotion of visual recovery. However, the intravitreal injections require to be repeated with high frequency, and this carries the risk of drug- and procedure-related adverse effects.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Bandello F,Preziosa C,Querques G,Lattanzio Rdoi
10.1159/000362764subject
Has Abstractpub_date
2014-01-01 00:00:00pages
89-96issue
2eissn
0030-3747issn
1423-0259pii
000362764journal_volume
52pub_type
杂志文章,评审abstract::Metabolic changes in the rabbit lens have been studied by means of nuclear magnetic resonance spectroscopy. These changes have been induced by prolonged topical treatment with dexamethasone. Our results demonstrate an increase in sorbitol, sorbitol-3-phosphate, fructose-3-phosphate, glycerol-3-phosphate and glucose-6-...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055646
更新日期:2001-03-01 00:00:00
abstract::Cholinergic agents used to lower intraocular pressure in the medical management of glaucoma act on muscarinic receptors in the eye. Recently, subtypes of muscarinic receptors have been recognized in many tissues including the eye. To localize the M3 muscarinic receptor subtype and m3 messenger RNA (mRNA) in the human ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267472
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:To compare intraocular pressure (IOP) measurements obtained with the digital tonometer TGDc-01 'PRA' with those from a Goldmann applanation tonometer (GAT). METHODS:The IOP in 176 eyes of 88 healthy volunteers was measured prospectively in a sitting position. One single measurement, generated by the TGDc-01...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000081204
更新日期:2004-09-01 00:00:00
abstract::The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267492
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:This study aimed to evaluate the longitudinal changes in retinal layers thickness in patients treated with hydroxychloroquine and no signs of retinal toxicity. METHODS:Longitudinal retrospective study of patients taking hydroxychloroquine followed in a hydroxychloroquine retinal toxicity screening program...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000511592
更新日期:2020-09-15 00:00:00
abstract:PURPOSE:Osthole is an agent isolated from Cnidium monnieri (L.) Cusson and has been used to treat several disorders. Corneal neovascularization is a sight-threatening condition associated with several inflammatory or infectious ocular disorders. In this study, we investigated the anti-angiogenic effects of osthole on c...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000505976
更新日期:2020-01-01 00:00:00
abstract::Local pO2 was measured close to the ciliary process of the rabbit eye using polarographic microelectrodes under microendoscopic observation. The experiments were performed in 5 anaesthetized New Zealand rabbits. Changes in local pO2, intraocular pressure (IOP) and blood flow velocity (BFV) were investigated after intr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267324
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line. METHODS:RF/6A cells were cultured in Dulbecco's modified Eagle's medium contai...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000369824
更新日期:2015-01-01 00:00:00
abstract:AIMS:The purpose of this paper was to determine the lacrimal concentration of IL-1α and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline. METHODS:After 4 weeks of therapy with azithromycin (500 mg/day, 3 days a week PO) or doxycycline (200 mg/day PO), la...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000489092
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the safety of suramin compared with mitomycin-C (MMC) as an adjunctive agent in trabeculectomy by determining its ciliary body toxicity at predetermined effective dosages in rabbit eyes. METHODS:Thirty-two New Zealand albino rabbits received either suramin (200, 300, 400, or 800 mg/ml) or M...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000187625
更新日期:2009-01-01 00:00:00
abstract::Diabetic macular edema is a common condition frequently encountered by ophthalmologists. In this piece we briefly review its definition, pathogenesis, clinical aspects, imaging, and treatment. ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000458535
更新日期:2017-01-01 00:00:00
abstract::Although it is essential that intraocular pressure (IOP) be reduced in glaucoma treatment, it is also vitally important to provide sufficient blood flow to eye tissues so that healthy visual field is maintained. It is possible for an agent to reduce IOP and blood supply to the eye. In that case, glaucoma appears to be...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265445
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Weak oxidants produced by activated human leukocytes are proven antimicrobial substances. We tested whether N-chlorotaurine (NCT, taurine chloramine), the chlorinated metabolite of the amino acid taurine, in addition to direct virucidal effects on viral suspensions, has the capability to prevent cell-to-cell ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000253846
更新日期:2010-01-01 00:00:00
abstract::The main objective of this study was to determine the intraocular concentration of fluorescein after applying five eye drops with only 1-min intervals in human eyes. The concentration of fluorescein in corea and aqueous was studied with fluorophotometry in 11 healthy volunteers. Five 10-microliter drops of 2% fluoresc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267997
更新日期:1997-01-01 00:00:00
abstract::Exposure of mice to hyperbaric oxygen leads to an inhibition of the mitotic activity in the germinative epithelium of the lens. This is followed by an eventual development of cataracts. Cataracts have also been observed in human beings treated with hyperbaric oxygen for different afflictions. The lens damage and catar...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266579
更新日期:1988-01-01 00:00:00
abstract::Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063881
更新日期:2002-07-01 00:00:00
abstract:AIM/BACKGROUND:A 1-bp deletion (1147delA) in the SAG (also known as arrestin or S-antigen) gene is the most frequently seen mutation in Japanese patients suffering from Oguchi disease, a recessively inherited stationary night blindness. We investigated macular function in a patient with Oguchi disease with the 1147delA...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000325024
更新日期:2011-10-01 00:00:00
abstract::The binding of fluorescein and 6-carboxyfluorescein by normal, diabetic and in vitro glycosylated human serum proteins was analyzed by absorption and fluorescence spectroscopy, gel filtration and equilibrium dialysis. The absorption spectra of bound fluorochromes showed red shifts and hypochromic changes, and fluoroch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265219
更新日期:1982-01-01 00:00:00
abstract::Modulation sensitivity functions ( MSFs ) of retinal ganglion cells of the pigeon were determined by recording action potentials from their end branching in the optic tectum as response indicator. The inverse Fourier transformation of a MSF is taken to represent the receptive field sensitivity function approximating t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265299
更新日期:1984-01-01 00:00:00
abstract::The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a variety of autoimmune diseases, including autoimmune uveitis. This brief review ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000510212
更新日期:2020-07-16 00:00:00
abstract::The high-voltage electron microscope (HVEM) permits examination of sections much thicker (up to 1 micron) than those usually used in transmission electron microscopy, which are approximately 70 nm in thickness. Two examples of the utility of the HVEM in research on the ultrastructure of the retinal pigment epithelium ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265457
更新日期:1986-01-01 00:00:00
abstract::VEGF is considered as an important factor in the pathogenesis of macular edema. VEGF induces the rupture of the blood retinal barrier and may also influence the retinal pigment epithelial (RPE) outer retinal barrier. The aim of this work was to analyze the influence of the VEGF receptor pathways in the modulation of t...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000119877
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To investigate the antiangiogenic effect of itraconazole for the prevention of experimentally induced corneal neovascularization and whether the efficacy depends on the route of administration. MATERIALS AND METHODS:Thirty-six rats were randomly divided into 6 groups with 6 rats in each group. Chemical cauteri...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000366283
更新日期:2014-01-01 00:00:00
abstract::L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265470
更新日期:1987-01-01 00:00:00
abstract::The aim of the present study was to investigate biochemical and morphological changes in rat lenses following long-term UV B irradiation. After an irradiation period of 156 days with follow-up documentation by means of Scheimpflug photography, section-related biochemical analyses of the lenses as well as histological ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267187
更新日期:1992-01-01 00:00:00
abstract::The pineal organ of the pike is a functional photoreceptive organ in which a multiplicity of the cells of the receptor line (CRL i.e. typical and modified photoreceptors) was demonstrated. The CRL appeared to be (i) regionally distributed, (ii) photosensitive, and (iii) responsible for the storage of various indoles (...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265306
更新日期:1984-01-01 00:00:00
abstract::The crystalline lens capsules of eye bank eyes, intraocular lens (IOL)-inserted eyes and those of monkey and rabbit eyes were observed in vivo and/or in vitro through a specular microscope or Scheimpflug slit images in combination with new image-processing techniques and scanning electron microscopy. Shagreen patterns...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266575
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To propose a new noncontact tonometer based on corneal photoelasticity. METHOD:In this study, we experimented with 18 enucleated porcine eyes. The anterior chamber was infused with a physiological solution. A circular polarizing filter was attached to an ophthalmic surgical microscope. Color fringe changes at ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000320600
更新日期:2011-01-01 00:00:00
abstract::In order to develop a more adequate ultraviolet (UV)-induced cataract model, a combination of l-buthionine sulfoximine (BSO) treatment was applied to experimental animals. A single administration of BSO 4 mmol/kg caused reduced glutathione concentration until experimental day 8. In the 0.067-J/cm2 UV-B irradiation exp...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267957
更新日期:1996-01-01 00:00:00
abstract::To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isof...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000317060
更新日期:2011-01-01 00:00:00