Aberrant expression of δ-like ligand 4 contributes significantly to axillary lymph node metastasis and predicts postoperative outcome in breast cancer.

abstract：:Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...

journal_title：Human pathology

authors： Zhang M,Adeniran AJ,Vikram R,Tamboli P,Pettaway C,Bondaruk J,Liu J,Baggerly K,Czerniak B

更新日期：2018-02-01 00:00:00

abstract：:Adamantinoma of the long bones is a rare, typically low-grade malignant tumor that frequently involves the tibia. Radiographically, adamantinoma is characteristically a lytic, intracortical, and expansile lesion with variable margins. Histologically, adamantinoma is a bimorphic neoplasm, composed of epithelial and ost...

journal_title：Human pathology

authors： Dashti NK,Howe BM,Inwards CY,Fritchie KJ,Carter JM

更新日期：2019-09-01 00:00:00

abstract：:After endoscopic resection of early gastric cancer (EGC), it is imperative to accurately determine whether follow-up surgery is indicated, since this technique is used as a first line of treatment. Herein, we developed a scoring system to indicate the risk of lymph node metastasis in submucosal EGC (smEGC), and presen...

journal_title：Human pathology

authors： Kim JY,Kim WG,Jeon TY,Kim GH,Jeong EH,Kim DH,Park DY,Lauwers GY

更新日期：2013-12-01 00:00:00

abstract：:GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The cop...

journal_title：Human pathology

authors： Gopalan V,Smith RA,Nassiri MR,Yasuda K,Salajegheh A,Kim SY,Ho YH,Weinstein S,Tang JC,Lam AK

更新日期：2010-07-01 00:00:00

abstract：:The Renal Pathology Society proposed a pathological classification for diabetic nephropathy (DN) (RPS 2010). We retrospectively examined the renal structural-functional relationships using the RPS 2010 classification in 49 DN cases. We also evaluated the importance of the percentage of glomeruli with nodular diabetic ...

journal_title：Human pathology

authors： Yasuda F,Mii A,Morita M,Aoki M,Tagawa M,Aratani S,Kaneko T,Sakai Y,Shimizu A

更新日期：2018-05-01 00:00:00

abstract：:Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gene silencing. Many cancer entities feature overexpression of HDACs. Cu...

journal_title：Human pathology

authors： Klieser E,Urbas R,Stättner S,Primavesi F,Jäger T,Dinnewitzer A,Mayr C,Kiesslich T,Holzmann K,Di Fazio P,Neureiter D,Swierczynski S

更新日期：2017-07-01 00:00:00

abstract：:A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ-light chains (LCs) were revealed by se...

journal_title：Human pathology

authors： Figueres ML,Beaume J,Vuiblet V,Rabant M,Bassilios N,Herody M,Touchard G,Noël LH

更新日期：2015-01-01 00:00:00

abstract：:Recent studies demonstrated that protease-activated receptor-2 (PAR-2) correlates with tumor progression in various tissues. On the other hand, oxidative stress arising from endometriosis has been considered a cause of carcinogenesis in ovarian clear cell carcinoma (OCCC). We previously demonstrated that oxidative str...

journal_title：Human pathology

authors： Aman M,Ohishi Y,Imamura H,Shinozaki T,Yasutake N,Kato K,Oda Y

更新日期：2017-06-01 00:00:00

abstract：:Histological criteria for the diagnosis of reflux esophagitis include basal zone hyperplasia, stromal papillae elongation, and inflammatory infiltrate. However, endoscopic esophageal biopsy specimens may include little or no lamina propria. Intraepithelial T lymphocytes, seen in hematoxylin and eosin-stained sections ...

journal_title：Human pathology

authors： Esposito S,Valente G,Zavallone A,Guidali P,Rapa A,Oderda G

更新日期：2004-01-01 00:00:00

abstract：:Except for post-transfusion hepatitis (PTH), the transmission of disease by blood transfusion appears to be very limited. There are only a few case reports documenting the transmission of malaria and other parasitic diseases, syphilis, or bacterial infections. The ability to eradicate PTH will depend on the developmen...

journal_title：Human pathology

authors： Kahn RA

更新日期：1983-03-01 00:00:00

abstract：:The significance of the quantity of acidophil bodies (AB) in nonalcoholic steatohepatitis (NASH) is not certain. We quantified AB in liver biopsies and examined the association with the diagnosis of NASH and other histologic features. We reviewed 157 liver biopsies from the NASH Clinical Research Network Database coll...

journal_title：Human pathology

authors： Yeh MM,Belt P,Brunt EM,Kowdley KV,Wilson LA,Ferrell L,Nonalcoholic Steatohepatitis Clinical Research Network.

更新日期：2016-06-01 00:00:00

abstract：:A 51-year-old man presented with a paratracheal tumor. He had undergone resection of a thyroid tumor 15 years previously; at that time, the histologic diagnosis had been anaplastic carcinoma. When the tumor recurred, the presumptive clinical diagnosis was medullary thyroid carcinoma. Histologic examination revealed a ...

journal_title：Human pathology

authors： Asa SL,Dardick I,Van Nostrand AW,Bailey DJ,Gullane PJ

更新日期：1988-12-01 00:00:00

abstract：:Sneddon's syndrome is a potentially fatal arterio-occlusive disorder characterized by generalized livedo racemosa and cerebrovascular lesions. Skin biopsies often fail to yield diagnostic arterial lesions. In the present series, affected vessels were found in skin biopsies from 12 of 15 patients with Sneddon's syndrom...

journal_title：Human pathology

authors： Zelger B,Sepp N,Schmid KW,Hintner H,Klein G,Fritsch PO

更新日期：1992-06-01 00:00:00

abstract：:The benign epithelial neoplasm liver cell adenoma is rare, especially in childhood. We report 2 such cases, 1 of which was associated with Prader-Willi syndrome. Differential diagnosis of the liver cell adenomas on the basis of histopathologic findings proved difficult and was based on the absence of cellular and nucl...

journal_title：Human pathology

authors： Takayasu H,Motoi T,Kanamori Y,Kitano Y,Nakanishi H,Tange T,Nakagawara A,Hashizume K

更新日期：2002-08-01 00:00:00

abstract：:The concept of minimal deviation melanoma is presented in diagrammatic form. In this approach, the precursors of melanoma are presented as having two dimensions and melanomas as having three dimensions. In turn, the relativity between dimensionalities and recommendations for treatment (as indirect correlates of progno...

journal_title：Human pathology

authors： Reed RJ

更新日期：1999-05-01 00:00:00

abstract：:Hyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majo...

journal_title：Human pathology

authors： García JJ,Jin L,Jackson SB,Larsen BT,Lewis JE,Sukov WR,Roden AC

更新日期：2015-03-01 00:00:00

abstract：:This article presents a view of lymphoid tissue architecture as defined by the traffic of defined lymphoid cell classes. The compartmentalization of lymphocytes is discussed in reference to specific cell-cell interactions that occur in antigen-driven immune responses. Finally, the distribution of normal and neoplastic...

journal_title：Human pathology

authors： Weissman IL,Warnke R,Butcher EC,Rouse R,Levy R

更新日期：1978-01-01 00:00:00

abstract：:Heterotopic pancreatic parenchyma recapitulates the normal pancreas in extrapancreatic locations and, on rare occasions, can even give rise to pancreatic adenocarcinoma. The genetic signatures of pancreatic adenocarcinoma and its precursor lesions are well characterized. We explored the genetic alterations in precurso...

journal_title：Human pathology

authors： Ma C,Gocke CD,Hruban RH,Belchis DA

更新日期：2016-02-01 00:00:00

abstract：:Acinar cell carcinoma (ACC) is a rare tumor that differentiates toward pancreatic acinar cells and shows evidence of pancreatic enzyme production. Mixed acinar-neuroendocrine carcinoma (MANC) is defined as having more than 30% of both acinar and neuroendocrine cell types as per immunohistochemistry analysis. Trypsin i...

journal_title：Human pathology

authors： Said S,Kurtin PJ,Nasr SH,Graham RP,Dasari S,Vrana JA,Yasir S,Torbenson MS,Zhang L,Mounajjed T,Eric Chen ZM,Lee HE,Wu TT

更新日期：2020-09-01 00:00:00

abstract：:The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase f...

journal_title：Human pathology

authors： Boiocchi L,Hasserjian RP,Pozdnyakova O,Wong WJ,Lennerz JK,Le LP,Dias-Santagata D,Iafrate AJ,Hobbs GS,Nardi V

更新日期：2019-04-01 00:00:00

abstract：:An increase in S100 protein-positive cells has been reported in inflammatory bowel diseases, mainly Crohn disease. These cells were interpreted as myeloid-derived dendritic cells, chiefly in follicular areas. We were prompted to assess the nature of these cells in interfollicular areas of inflamed colonic mucosa in ul...

journal_title：Human pathology

authors： Mosnier JF,Jarry A,Camdessanché JP,Antoine JC,Laboisse CL

更新日期：2009-08-01 00:00:00

abstract：:T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PL...

journal_title：Human pathology

authors： Hu Z,Li S,Medeiros LJ,Sun T

更新日期：2017-07-01 00:00:00

abstract：:As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GISTs), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor ...

journal_title：Human pathology

authors： Fletcher CD,Berman JJ,Corless C,Gorstein F,Lasota J,Longley BJ,Miettinen M,O'Leary TJ,Remotti H,Rubin BP,Shmookler B,Sobin LH,Weiss SW

更新日期：2002-05-01 00:00:00

abstract：:Ewing sarcoma (ES) is an aggressive malignant small round cell tumor that arises in bone or soft tissue of adolescents and young adults. A characteristic molecular finding in ES is EWSR1 gene fusion with ETS (erythroblast transformation-specific) family genes including FLI1 (~90%) and ERG (>5%). Here we report our exp...

journal_title：Human pathology

authors： Warren M,Weindel M,Ringrose J,Venable C,Reyes A,Terashima K,Rao P,Chintagumpala M,Hicks MJ,Lopez-Terrada D,Lu XY

更新日期：2013-10-01 00:00:00

abstract：:Twenty-six women with multiple human papillomavirus (HPV)-related lesions of the lower genital tract were investigated by immunohistochemistry for the internal genus-specific capsid antigen of HPV and by DNA-DNA in situ hybridization with 35S-radiolabeled probes for sequences of HPV-6/11, HPV-16, and HPV-18. The vulva...

journal_title：Human pathology

authors： Pilotti S,Gupta J,Stefanon B,De Palo G,Shah KV,Rilke F

更新日期：1989-02-01 00:00:00

abstract：:To ensure appropriate mission-based budgeting and equitable distribution of funds for faculty salaries, our compensation committee developed a pathology-specific effort reporting database. Principles included the following: (1) measurement should be done by web-based databases; (2) most entry should be done by departm...

journal_title：Human pathology

authors： Dee FR,Haugen TH,Wynn PA,Leaven TC,Kemp JD,Cohen MB

更新日期：2008-04-01 00:00:00

abstract：:Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...

journal_title：Human pathology

authors： Lu Z,Al-Obaidy K,Cheng L,Perry KD,Grignon DJ,Williamson SR

更新日期：2018-12-01 00:00:00

abstract：:Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on...

journal_title：Human pathology

authors： Kim MS,In SG,Park OJ,Won CH,Lee MW,Choi JH,Kim CW,Kim SE,Moon KC,Chang S

更新日期：2011-07-01 00:00:00

abstract：:A 61-year-old woman was admitted to the hospital because of general fatigue. Laboratory examinations showed hyponatremia, plasma hypo-osmolarity, and inappropriate increased concentration of the plasma antidiuretic hormone (ADH) in the presence of concentrated urine. Magnetic resonance imaging revealed a mass lesion i...

journal_title：Human pathology

authors： Asada Y,Marutsuka K,Mitsukawa T,Kuribayashi T,Taniguchi S,Sumiyoshi A

更新日期：1996-05-01 00:00:00

abstract：:Laminin and collagen have been studied in several tumor types and their immunomorphological expression correlated with tumor morphogenesis, local invasiveness, and metastatic behavior. In a series of 53 cases of pleomorphic adenomas (PA) and 16 cases of carcinomas ex-pleomorphic adenoma (Ca ex-PA), we investigated by ...

journal_title：Human pathology

authors： Félix A,Rosa JC,Fonseca I,Cidadão A,Soares J

更新日期：1999-08-01 00:00:00