Correlations between major risk factors and closely related Mycobacterium tuberculosis isolates grouped by three current genotyping procedures: a population-based study in northeast Mexico.

Abstract:

:The characteristics of tuberculosis (TB) patients related to a chain of recent TB transmissions were investigated. Mycobacterium tuberculosis (MTB) isolates (120) were genotyped using the restriction fragment length polymorphism-IS6110 (R), spacer oligotyping (S) and mycobacterial interspersed repetitive units-variable number of tandem repeats (M) methods. The MTB isolates were clustered and the clusters were grouped according to the similarities of their genotypes. Spearman's rank correlation coefficients between the groups of MTB isolates with similar genotypes and those patient characteristics indicating a risk for a pulmonary TB (PTB) chain transmission were ana- lysed. The isolates showing similar genotypes were distributed as follows: SMR (5%), SM (12.5%), SR (1.67%), MR (0%), S (46.67%), M (5%) and R (0%). The remaining 35 cases were orphans. SMR exhibited a significant correlation (p < 0.05) with visits to clinics, municipalities and comorbidities (primarily diabetes mellitus). S correlated with drug consumption and M with comorbidities. SMR is needed to identify a social network in metropolitan areas for PTB transmission and S and M are able to detect risk factors as secondary components of a transmission chain of TB.

journal_name

Mem Inst Oswaldo Cruz

authors

Peñuelas-Urquides K,Martínez-Rodríguez HG,Enciso-Moreno JA,Molina-Salinas GM,Silva-Ramírez B,Padilla-Rivas GR,Vera-Cabrera L,Torres-de-la-Cruz VM,Martínez-Martínez YB,Ortega-García JL,Garza-Treviño EN,Enciso-Moreno L,Saucedo-Cárd

doi

10.1590/0074-0276130550

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

814-9

issue

6

eissn

0074-0276

issn

1678-8060

pii

S0074-02762014000600814

journal_volume

109

pub_type

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