Abstract:
BACKGROUND:Juvenile idiopathic arthritis (JIA) is a chronic, heterogenous inflammatory disease of unclear pathogenesis. JIA is hypothesized to be linked to a defective immune regulation. Anti-inflammatory cytokines belong to the best known regulatory factors. T-regulatory cells are a crucial cellular component of immune tolerance. One of their functions is synthesis of interleukin 10 (IL-10) and transforming growth factor beta1 (TGF-β1). The aim of this study was to determine the proportion of T-regulatory cells (CD4+CD25highFOXP3+) in peripheral blood, and serum levels of TGF-β1 and IL-10 in patients with JIA. METHODS:The study included 25 patients with newly diagnosed JIA: oligoarthritis (n=17) and polyarthritis (n=8). The control group was comprised of 17 healthy children. CD4+CD25highFOXP3+ T cells in peripheral blood were quantified by means of three-color flow cytometry. Serum concentrations of TGF-β1 and IL-10 were estimated with ELISA. RESULTS:The proportion of peripheral CD4+CD25highFOXP3+ cells in patients with JIA was significantly higher than in the controls (p=0.04). The two groups did not differ significantly in terms of their TGF-β1 and IL-10 concentrations. CONCLUSIONS:At the time of diagnosis, children with JIA presented with an elevated proportion of T-regulatory cells (CD4+CD25highFOXP3+) in peripheral blood. Anti-inflammatory cytokines, IL-10 and TGF-β1, are not upregulated in the serum of patients with JIA, and therefore should not be considered as biomarkers of this condition.
journal_name
Acta Biochim Poljournal_title
Acta biochimica Polonicaauthors
Sznurkowska K,Boćkowska M,Zieliński M,Plata-Nazar K,Trzonkowski P,Liberek A,Kamińska B,Szlagatys-Sidorkiewicz Adoi
10.18388/abp.2017_2308subject
Has Abstractpub_date
2018-01-01 00:00:00pages
119-123issue
1eissn
0001-527Xissn
1734-154Xpii
2308journal_volume
65pub_type
杂志文章abstract::Mushroom foraging is very popular in some regions of the world. Sometimes toxic and edible mushrooms are mistaken by mushroom collectors, leading to serious human poisoning. The group of mushrooms highly dangerous for human health includes Amanita phalloides. This mushroom produces a toxic octapeptide called α-amaniti...
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:0249041029
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journal_title:Acta biochimica Polonica
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doi:
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journal_title:Acta biochimica Polonica
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journal_title:Acta biochimica Polonica
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doi:
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journal_title:Acta biochimica Polonica
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abstract::Geranylgeranyl diphosphate (GGPP) synthase was purified to homogeneity from bovine brain in a one-step affinity column procedure. For the construction of the affinity column, a farnesyl diphosphate (FPP) analog, O-(6-amino-1-hexyl)-P-farnesylmethyl phosphonophosphate, was synthesized and linked to the spacer of the ma...
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doi:
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pub_type: 杂志文章,评审
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
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abstract::Progressive decline in fertility and sperm quality has been reported over the last few decades, especially in industrialized nations. It has been proposed that exposure to factors that induce damage in DNA of spermatogenic cells may significantly contribute to impaired fertility. Here, the (32)P-postlabelling method w...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:035001197
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::Influenza A virus infections are the major public health concern and cause significant morbidity and mortality each year worldwide. Vaccination is the main strategy of influenza epidemic prevention. However, seasonal vaccines induce strain-specific immunity and must be reformulated annually based on prediction of the ...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::The urinary tract is vulnerable to frequent challenges from environmental microflora. Uropathogenic Escherichia coli (UPEC) makes a major contribution to urinary tract infection (UTI). Previous studies have characterized positive roles of non-histone nuclear protein HMGN2 in lung epithelial innate immune response. In ...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2017_1622
更新日期:2018-01-01 00:00:00
abstract::Basing on the use of highly specific antibodies it has been proved that ACTH induces synthesis of cytochrome P-450 and adrenodoxin in cultured adrenal cortex cells. ...
journal_title:Acta biochimica Polonica
pub_type: 更正并重新发布的文章,杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The use of fluorescent markers has proven to be an attractive tool in biological imaging. However, its usefulness may be confined by the cytotoxicity of the fluorescent proteins. In this article, for the first time, we have examined an influence of the antibiotics present in culture medium on cytotoxicity of the EGFP ...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::There are many diseases related to ion channels. Mutations in muscle voltage-gated sodium, potassium, calcium and chloride channels, and acetylcholine-gated channel may lead to such physiological disorders as hyper- and hypokalemic periodic paralysis, myotonias, long QT syndrome, Brugada syndrome, malignant hypertherm...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::The endogenous electric field may provide an important signal for directional cell migration during cancer metastasis but the mechanism of cell electrotaxis is poorly understood. It was postulated that microtubules play a central role in the polarization and directional migration of several types of cells. In this pap...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2015_1019
更新日期:2015-01-01 00:00:00
abstract::Lanthanides, also called rare-earth elements, are an interesting group of 15 chemically active, mainly trivalent, f-electronic, silvery-white metals. In fact, lanthanides are not as rare as the name implies, except for promethium, a radioactive artificial element not found in nature. The mean concentrations of lanthan...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::The properties of red blood cell membranes in patients with chronic renal failure were investigated using electron paramagnetic resonance spectroscopy. Using spin traps, 5,5-dimethylpirroline-1 oxide and N-tert-butyl-alpha-phenylnitrone, we found generation of hydroxyl radicals in the blood of patients with chronic re...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
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abstract::Diabetes is one of the major challenges of modern medicine, as it is considered a global epidemic of the XXI century. The disease often leads to the development of serious, health threatening complications. Diabetic foot syndrome is a characteristic set of anatomical and molecular changes. At the macroscopic level, ma...
journal_title:Acta biochimica Polonica
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doi:
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
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journal_title:Acta biochimica Polonica
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doi:
更新日期:2011-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
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abstract::This brief resume enumerates the multiple actions of melatonin as an antioxidant. This indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other organs. Additionally, however, it is found in invertebrates, bacteria, unicellular organisms as well as in plants, all of which do not have a...
journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
abstract::Recently, embryo muscle development, which is crucial for postnatal skeletal muscle growth, has been investigated widely. Nutrients in ovo were suggested to be critical in embryo muscle development since the chick growth mostly relies on nutrients in eggs at the early developmental stage. Phytosterol esters (PE), whic...
journal_title:Acta biochimica Polonica
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abstract::The approach for the unification of published proposals for the nomenclature and abbreviations of aminoalkylphosphonic acids and their derivatives is presented. Their modification was made on the basis of the IUPAC-IUB rules concerning the nomenclature and code system of proteinogenic amino acids. Our present proposal...
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