The path to metastatic mouse models of colorectal cancer.

abstract：:Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region that contains one or two Polo-boxes. For Polo-like kinase 1, 2, and 3, and their homologs, the entire C-terminal region, including ...

journal_title：Oncogene

authors： Lowery DM,Lim D,Yaffe MB

更新日期：2005-01-10 00:00:00

abstract：:Raf-1 is a serine-threonine protein kinase that functions as a central component of the mitogen-activated protein kinase signal transduction pathway. Raf-1 activity is currently assayed in vitro by either measuring 32P incorporation into MEK, Raf-1's only characterized substrate, or by using the phosphorylated MEK to ...

journal_title：Oncogene

authors： Bondzi C,Grant S,Krystal GW

更新日期：2000-10-12 00:00:00

abstract：:Although TGFalpha mRNA and protein are frequently elevated in neoplastic cells, neither the level at which deregulation occurs nor the mechanism(s) responsible have been well characterized. As a first step, we examined the induction of TGFalpha mRNA in two series of clonally-derived rat liver epithelial cell lines tha...

journal_title：Oncogene

authors： Berkowitz EA,Hissong MA,Lee DC

更新日期：1996-05-02 00:00:00

abstract：:Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle, especially during mitosis. Antimitotic drugs trigger mitotic checkpoint activation, mitotic arrest and eventually cell death. However, mitotic slippage represents a major mechanism of resistance to these treatments. I...

journal_title：Oncogene

authors： Sánchez-Pérez T,Medema RH,López-Rivas A

更新日期：2015-01-29 00:00:00

abstract：:During the evolution into castration or therapy resistance, prostate cancer cells reprogram the androgen responses to cope with the diminishing level of androgens, and undergo metabolic adaption to the nutritionally deprived and hypoxia conditions. AR (androgen receptor) and PKM2 (pyruvate kinase M2) have key roles in...

journal_title：Oncogene

authors： Wang HJ,Pochampalli M,Wang LY,Zou JX,Li PS,Hsu SC,Wang BJ,Huang SH,Yang P,Yang JC,Chu CY,Hsieh CL,Sung SY,Li CF,Tepper CG,Ann DK,Gao AC,Evans CP,Izumiya Y,Chuu CP,Wang WC,Chen HW,Kung HJ

更新日期：2019-01-01 00:00:00

abstract：:Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that the molecular structure of EWS-ETS lacks prognostic value. Moreover, CDKN2A deletion and TP53 mutation, despite...

journal_title：Oncogene

authors： Mackintosh C,Ordóñez JL,García-Domínguez DJ,Sevillano V,Llombart-Bosch A,Szuhai K,Scotlandi K,Alberghini M,Sciot R,Sinnaeve F,Hogendoorn PC,Picci P,Knuutila S,Dirksen U,Debiec-Rychter M,Schaefer KL,de Álava E

更新日期：2012-03-08 00:00:00

abstract：:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), a gamma-2 herpesvirus, is the causative agent of KS, primary effusion lymphoma (PEL), and a plasma cell variant of multicentric Castleman's disease. Although KSHV latency is detected in KS-related tumors, oncogenic pathways activated by KSHV latent infection are not...

journal_title：Oncogene

authors： Nakayama R,Ueno Y,Ueda K,Honda T

更新日期：2019-05-01 00:00:00

abstract：:After publication of this Article, the Authors noticed errors in some of the Figures. In Figures 2e, 2f-g, 4a, 4j, 5a and 6b, unmatched β-actin was inadvertently used as loading control for the immunoblots. These have been corrected using repeat data from a similar set of samples and the revised Figures containing mat...

journal_title：Oncogene

authors： Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

更新日期：2020-10-01 00:00:00

abstract：:Understanding the molecular mechanisms that underlie the aggressive behavior and relapse of breast cancer may help in the development of novel therapeutic interventions. CUB-domain-containing protein 1 (CDCP1), a transmembrane adaptor protein, is highly maintained and required in the context of cellular metastatic pot...

journal_title：Oncogene

authors： Cui YH,Kim H,Lee M,Yi JM,Kim RK,Uddin N,Yoo KC,Kang JH,Choi MY,Cha HJ,Kwon OS,Bae IH,Kim MJ,Kaushik N,Lee SJ

更新日期：2018-10-01 00:00:00

abstract：:Minichromosome maintenance (MCM) proteins 2-7 are important in DNA replication licensing. Functional roles beyond licensing are speculated. In addition, significances in medulloblastoma (MB) remain unclear. In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinica...

journal_title：Oncogene

authors： Lau KM,Chan QK,Pang JC,Li KK,Yeung WW,Chung NY,Lui PC,Tam YS,Li HM,Zhou L,Wang Y,Mao Y,Ng HK

更新日期：2010-10-07 00:00:00

abstract：:A protein of 300 kDa (p300) associates with the adenovirus E1A proteins and has been implicated in the control of cell cycle progression. In mammalian cells, p300 is actively phosphorylated in both quiescent and proliferating cells and its level of phosphorylation increases as it travels from late G1 into M phase. E1A...

journal_title：Oncogene

authors： Banerjee AC,Recupero AJ,Mal A,Piotrkowski AM,Wang DM,Harter ML

更新日期：1994-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...

journal_title：Oncogene

authors： Catalano A,Romano M,Martinotti S,Procopio A

更新日期：2002-04-25 00:00:00

abstract：:The fate of cells exposed to ionizing radiation (IR) may depend greatly on changes in gene expression, so that an improved view of gene induction profiles is important for understanding mechanisms of checkpoint control, repair and cell death following such exposures. We have used a quantitative fluorescent cDNA microa...

journal_title：Oncogene

authors： Amundson SA,Bittner M,Chen Y,Trent J,Meltzer P,Fornace AJ Jr

更新日期：1999-06-17 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with highly aggressive and metastatic potential in which distant metastasis is the main reason for treatment failure. Till present, the underlying molecular mechanisms of NPC metastasis remains poorly understood. Here, we identified S100 calcium-binding p...

journal_title：Oncogene

authors： Meng DF,Sun R,Liu GY,Peng LX,Zheng LS,Xie P,Lin ST,Mei Y,Qiang YY,Li CZ,Xu L,Peng XS,Hu H,Lang YH,Liu ZJ,Wang MD,Guo LL,Xie DH,Shu DT,Li HF,Luo FF,Niu XT,Huang BJ,Qian CN

更新日期：2020-07-01 00:00:00

abstract：:rho genes have been found in both lower and higher eucaryotes. They code for proteins of 21 kDa, highly conserved in evolution, which belong to the superfamily of ras GTPases. Among the members of this superfamily there are proteins with a regulatory function, such as ras, and proteins involved in vesicular traffickin...

journal_title：Oncogene

authors： Perona R,Esteve P,Jiménez B,Ballestero RP,Ramón y Cajal S,Lacal JC

更新日期：1993-05-01 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more...

journal_title：Oncogene

authors： Fessler E,Jansen M,De Sousa E Melo F,Zhao L,Prasetyanti PR,Rodermond H,Kandimalla R,Linnekamp JF,Franitza M,van Hooff SR,de Jong JH,Oppeneer SC,van Noesel CJ,Dekker E,Stassi G,Wang X,Medema JP,Vermeulen L

更新日期：2016-11-17 00:00:00

abstract：:Although apoptosis can be induced by the enforced expression of exogenously introduced c-myc genes, it is not clear whether overexpression resulting from the amplification of the resident c-myc gene in tumor cells is sufficient to induce apoptosis. We have investigated the relationship between c-myc gene amplification...

journal_title：Oncogene

authors： Donzelli M,Bernardi R,Negri C,Prosperi E,Padovan L,Lavialle C,Brison O,Scovassi AI

更新日期：1999-01-14 00:00:00

abstract：:Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF an...

journal_title：Oncogene

authors： Kim SW,Kim HJ,Jung DJ,Lee SK,Kim YS,Kim JH,Kim TS,Lee JW

更新日期：2001-10-04 00:00:00

abstract：:Many p53 mutants found in human cancer have an altered ability to bind DNA and transactivate gene expression. Re-expression of functional p53 in cells in which the endogenous TP53 gene is inactivated has been demonstrated to restore a non-tumorigenic phenotype. Pharmacological modulation of p53 mutant conformation may...

journal_title：Oncogene

authors： Maurici D,Monti P,Campomenosi P,North S,Frebourg T,Fronza G,Hainaut P

更新日期：2001-06-14 00:00:00

abstract：:Ki-1 lymphoma is a subtype of human malignant lymphoma characterized by the expression of CD30 (Ki-1) and a peculiar morphology. It is occasionally accompanied by a unique reciprocal chromosomal translocation t(2;5)(p23;q35). A Ki-1 lymphoma cell line, AMS3, was established by maintaining biopsied tumor cells in SCID ...

journal_title：Oncogene

authors： Shiota M,Fujimoto J,Semba T,Satoh H,Yamamoto T,Mori S

更新日期：1994-06-01 00:00:00

abstract：:Successful treatment of multiple cancer types requires early detection and identification of reliable biomarkers present in specific cancer tissues. To test the feasibility of identifying proteins from archival cancer tissues, we have developed a methodology, termed direct tissue proteomics (DTP), which can be used to...

journal_title：Oncogene

authors： Hwang SI,Thumar J,Lundgren DH,Rezaul K,Mayya V,Wu L,Eng J,Wright ME,Han DK

更新日期：2007-01-04 00:00:00

abstract：:Post-irradiation complications including thrombus formation result from increased procoagulant activity of vascular endothelial cells and elevated levels of von Willebrand factor (VWF) contribute to this process. We have previously demonstrated that irradiation induction of the VWF is mediated through interaction of N...

journal_title：Oncogene

authors： Peng Y,Stewart D,Li W,Hawkins M,Kulak S,Ballermann B,Jahroudi N

更新日期：2007-11-29 00:00:00

abstract：:Nuclear Foxc2 is a transcriptional regulator of mesenchymal transformation during developmental epithelial-mesenchymal transition (EMT) and has been associated with EMT in malignant epithelia. Our laboratory has shown that in normal epithelial cells Foxc2 is maintained in the cytoplasm where it promotes an epithelial ...

journal_title：Oncogene

authors： Golden D,Cantley LG

更新日期：2015-09-03 00:00:00

abstract：:The tumour suppressor p53 is a transcription factor with high affinity for specific DNA target sequences. Wild type p53 has a very short half life in normal cells but the protein shows transient accumulation in response to DNA damage, accompanied by up-regulation of target genes such as p21 and induction of growth arr...

journal_title：Oncogene

authors： Molinari M,Milner J

更新日期：1995-05-04 00:00:00

abstract：:TSG101 has been identified as a candidate tumor suppressor gene and abnormal transcripts have been identified in a substantial fraction of breast cancers. To determine whether TSG101 expression is commonly altered in other tumors, a series of 15 primary and metastatic prostate cancers were analysed by reverse transcri...

journal_title：Oncogene

authors： Sun Z,Pan J,Bubley G,Balk SP

更新日期：1997-12-18 00:00:00

abstract：:Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon ti...

journal_title：Oncogene

authors： Mossie K,Jallal B,Alves F,Sures I,Plowman GD,Ullrich A

更新日期：1995-11-16 00:00:00

abstract：:The cell polarity regulator, human Scribble (hScrib), is a potential tumour suppressor whose loss is a frequent event in late-stage cancer development. Little is yet known about the mode of action of hScrib, although recent reports suggest its role in the regulation of cell signalling. In this study we show that hScri...

journal_title：Oncogene

authors： Nagasaka K,Pim D,Massimi P,Thomas M,Tomaić V,Subbaiah VK,Kranjec C,Nakagawa S,Yano T,Taketani Y,Myers M,Banks L

更新日期：2010-09-23 00:00:00

abstract：:We have cloned and characterised the murine gene encoding c-Mpl, a receptor for thrombopoietin and member of the hematopoietin receptor superfamily. The gene encompasses 15 kb of the mouse genome and the organisation of its 12 exons conforms closely to the pattern observed for the genes of other hematopoietin receptor...

journal_title：Oncogene

authors： Alexander WS,Dunn AR

更新日期：1995-02-16 00:00:00

abstract：:Human WWOX gene encodes a proapoptotic WW domain-containing oxidoreductase WOX1 (also named WWOX, FOR2 or WWOXv1). Apoptotic and stress stimuli activate WOX1 via Tyr33 phosphorylation and nuclear translocation. WOX1 possesses a tetrad NSYK motif in the C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domai...

journal_title：Oncogene

authors： Chang NS,Schultz L,Hsu LJ,Lewis J,Su M,Sze CI

更新日期：2005-01-20 00:00:00

abstract：:We previously described the isolation of non-tumorigenic revertants from mutagenized populations of v-fos-transformed Rat-1 cells (Zarbl et al., 1987). In the present study we examined the possibility that the revertant phenotype resulted from mutations that altered the expression or activities of the c-jun or junB pr...

journal_title：Oncogene

authors： Van Amsterdam JR,Wang Y,Sullivan RC,Zarbl H

更新日期：1994-10-01 00:00:00