Stuttering, induced fluency, and natural fluency: a hierarchical series of activation likelihood estimation meta-analyses.

Abstract:

:Developmental stuttering is a speech disorder most likely due to a heritable form of developmental dysmyelination impairing the function of the speech-motor system. Speech-induced brain-activation patterns in persons who stutter (PWS) are anomalous in various ways; the consistency of these aberrant patterns is a matter of ongoing debate. Here, we present a hierarchical series of coordinate-based meta-analyses addressing this issue. Two tiers of meta-analyses were performed on a 17-paper dataset (202 PWS; 167 fluent controls). Four large-scale (top-tier) meta-analyses were performed, two for each subject group (PWS and controls). These analyses robustly confirmed the regional effects previously postulated as "neural signatures of stuttering" (Brown, Ingham, Ingham, Laird, & Fox, 2005) and extended this designation to additional regions. Two smaller-scale (lower-tier) meta-analyses refined the interpretation of the large-scale analyses: (1) a between-group contrast targeting differences between PWS and controls (stuttering trait); and (2) a within-group contrast (PWS only) of stuttering with induced fluency (stuttering state).

journal_name

Brain Lang

journal_title

Brain and language

authors

Budde KS,Barron DS,Fox PT

doi

10.1016/j.bandl.2014.10.002

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

99-107

eissn

0093-934X

issn

1090-2155

pii

S0093-934X(14)00147-3

journal_volume

139

pub_type

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