Abstract:
:The present study used the context preexposure facilitation effect (CPFE) to examine long-term retention of incidental context learning in periweanling, adolescent and adult rats. The CPFE is a variant of contextual fear conditioning in which encoding the context representation, associating this representation with shock, and expressing the context-shock association each occur on separate occasions. Experiment 1 manipulated the retention interval-1d, 8d, 15d, or 22d-between context preexposure and training with immediate shock to determine how long the encoded context could be remembered (testing always occurred 24h following training). The other factors were age-postnatal day (PND) 24 vs 31-and training group-Preexposed to the training context (Pre) vs. an alternate context (Alt-Pre). At both ages, significantly more freezing was evident in the Pre vs. Alt Pre Groups at the 24h, 8d and 15d retention intervals but not at the 22d interval, indicating that juvenile-adolescent rats remember the context for up to 15d. In contrast, context memory persists for 22days in adult rats (Experiment 2); and is not evident after 24h, 8d, or 15d retention intervals in PND 17 rats (Experiment 3). The present study illustrates the value of the CPFE paradigm for investigations of long-term context memory in developing rats. Implications for the neurobiology of infantile amnesia are discussed.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Robinson-Drummer PA,Stanton MEdoi
10.1016/j.physbeh.2014.12.033subject
Has Abstractpub_date
2015-09-01 00:00:00pages
22-8eissn
0031-9384issn
1873-507Xpii
S0031-9384(14)00657-Xjournal_volume
148pub_type
杂志文章abstract::Prenatal exposure to alcohol feminizes saccharin consumption patterns in adult male rats. To study the involvement of testosterone in this effect, testosterone propionate (TP) was administered to pregnant dams in an attempt to reverse that feminized saccharin consumption pattern in the male offspring. Female offspring...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(87)90016-3
更新日期:1987-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 临床试验,杂志文章
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doi:10.1016/s0031-9384(00)00332-2
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90249-9
更新日期:1982-10-01 00:00:00
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journal_title:Physiology & behavior
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doi:
更新日期:1996-08-01 00:00:00
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journal_title:Physiology & behavior
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doi:10.1016/j.physbeh.2004.05.011
更新日期:2004-09-30 00:00:00
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pub_type: 杂志文章
doi:10.1016/0031-9384(85)90073-3
更新日期:1985-01-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(76)90026-3
更新日期:1976-12-01 00:00:00
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doi:10.1016/j.physbeh.2015.01.014
更新日期:2015-03-15 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2004.10.022
更新日期:2005-01-31 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(83)80010-9
更新日期:1983-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(97)00024-3
更新日期:1997-08-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:1986-01-01 00:00:00
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更新日期:2018-10-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(82)90211-6
更新日期:1982-05-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(90)90127-p
更新日期:1990-03-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(77)90342-0
更新日期:1977-08-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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journal_title:Physiology & behavior
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更新日期:2019-09-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(96)00306-x
更新日期:1996-12-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.12.015
更新日期:2009-03-23 00:00:00