Dietary cysteine and other amino acids and stroke incidence in women.

Abstract:

BACKGROUND AND PURPOSE:Cysteine could potentially lower the risk of stroke through antihypertensive and antioxidant effects. Our aim was to evaluate the hypothesis that cysteine intake is inversely associated with stroke incidence. METHODS:We used data from the Swedish Mammography Cohort, a population-based prospective cohort of 34 250 women who were free of cardiovascular disease and cancer and had completed a food-frequency questionnaire about diet and other risk factors for stroke in the autumn of 1997. Stroke cases were identified by linkage of the study population with the Swedish Inpatient Register and the Swedish Cause of Death Register. Relative risks (RR) with 95% confidence intervals, adjusted for potential confounders, were estimated by using Cox proportional hazards regression model. RESULTS:We ascertained 1751 incident cases of stroke during 10.4 years of follow-up. Dietary cysteine intake (mean, 635 mg/d) was inversely associated with stroke risk. The multivariable RR of total stroke comparing the highest with the lowest quintile of cysteine intake was 0.79 (95% confidence interval, 0.65-0.97; P for trend=0.04). The corresponding RR was 0.82 (95% confidence interval, 0.65-1.03; P for trend=0.12) for cerebral infarction and 0.54 (95% confidence interval, 0.29-1.03; P for trend=0.08) for intracerebral hemorrhage. Dietary intake of other amino acids showed no independent (after adjustment for cysteine intake) association with stroke risk. CONCLUSIONS:These findings suggest that dietary cysteine intake may be inversely associated with risk of stroke. CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT01127698.

journal_name

Stroke

journal_title

Stroke

authors

Larsson SC,Håkansson N,Wolk A

doi

10.1161/STROKEAHA.114.008022

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

922-6

issue

4

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.114.008022

journal_volume

46

pub_type

临床试验,杂志文章

相关文献

STROKE文献大全
  • Correlations between clinical findings and magnetization transfer imaging metrics of tissue damage in individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

    abstract:BACKGROUND AND PURPOSE:We obtained magnetization transfer imaging (MTI) scans from individuals with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (1) to investigate the presence, extent, and nature of pathology in white and gray matter outside proton density (PD)-v...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.32.3.643

    authors: Iannucci G,Dichgans M,Rovaris M,Brüning R,Gasser T,Giacomotti L,Yousry TA,Filippi M

    更新日期:2001-03-01 00:00:00

  • Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:Central nervous system serotonergic neurotransmission appears to play a role in mood disorders, eating habits, and sleep, and also modulates blood pressure and metabolism. This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.106.477638

    authors: Muldoon MF,Mackey RH,Sutton-Tyrrell K,Flory JD,Pollock BG,Manuck SB

    更新日期:2007-08-01 00:00:00

  • Spreading of vasogenic edema and cytotoxic edema assessed by quantitative diffusion and T2 magnetic resonance imaging.

    abstract:BACKGROUND AND PURPOSE:The apparent diffusion coefficient (ADC) of water should be sensitive to the cytotoxic edema triggered by energy failure during ischemia. Elevated values of T2. the nuclear MR transverse relaxation time of water, seen on T2 nuclear MR images detect vasogenic edema and infarcted areas. The tempora...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.2.419

    authors: Loubinoux I,Volk A,Borredon J,Guirimand S,Tiffon B,Seylaz J,Méric P

    更新日期:1997-02-01 00:00:00

  • Thrombotic risk factors in primary antiphospholipid syndrome: a 5-year prospective study.

    abstract:BACKGROUND AND PURPOSE:Because thromboembolic events are frequently observed in primary antiphospholipid syndrome (PAPS), we assessed the risk factors for new thrombotic episodes. METHODS:Fifty-six PAPS patients (mean age, 37+/-10 years) were prospectively studied for 5 years. The preliminary Sapporo classification cr...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000170645.40562.09

    authors: Turiel M,Sarzi-Puttini P,Peretti R,Rossi E,Atzeni F,Parsons W,Doria A

    更新日期:2005-07-01 00:00:00

  • Mechanism of ATP-induced [Ca(2+)](i) mobilization in rat basilar smooth muscle cells.

    abstract:BACKGROUND AND PURPOSE:We have previously reported that extracellular ATP activates P(2u) receptors and increases intracellular free Ca(2+) ([Ca(2+)](i)) by G protein/phospholipase C/inositol 1,4,5-triphosphate pathways in cerebral artery smooth muscle cells. However, the possible contribution of other signaling pathwa...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.6.1377

    authors: Aoki K,Zubkov AY,Parent AD,Zhang JH

    更新日期:2000-06-01 00:00:00

  • Relative value of normalized sonographic in vitro analysis of arteriosclerotic plaques of internal carotid artery.

    abstract:BACKGROUND AND PURPOSE:A close correlation between B-mode sonography and the histopathology and surface structure of plaque is rarely seen in vivo with high-grade stenoses of the extracranial carotid artery. The goal of this study was to determine whether normalized gray scale analysis and surface analysis of the plaqu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000081982.85010.A8

    authors: Denzel C,Balzer K,Müller KM,Fellner F,Fellner C,Lang W

    更新日期:2003-08-01 00:00:00

  • Chronic depression of glucose metabolism in postischemic rat brains.

    abstract:BACKGROUND AND PURPOSE:The present investigation aimed to quantify functional activity in rat brains after long-term recovery from transient forebrain ischemia. METHODS:With the use of the [14C]2-deoxyglucose method, local cerebral glucose utilization was measured in 62 cortical and subcortical brain regions in postis...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.6.1107

    authors: Beck T,Goller HJ,Wree A

    更新日期:1995-06-01 00:00:00

  • Safety of intra-arterial thrombolysis in the postoperative period.

    abstract:BACKGROUND AND PURPOSE:Limited systemic fibrinolysis and reduced dosage are features of intra-arterial thrombolyis (IAT) that may be advantageous in the treatment of postoperative strokes. However, IAT may increase the risk of surgical bleeding. We sought to determine the safety of postoperative IAT. METHODS:This was ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.6.1365

    authors: Chalela JA,Katzan I,Liebeskind DS,Rasmussen P,Zaidat O,Suarez JI,Chiu D,Klucznick RP,Jauch E,Cucchiara BL,Saver J,Kasner SE

    更新日期:2001-06-01 00:00:00

  • Problems of carotid Doppler scanning which can be overcome by using frequency analysis.

    abstract::The value of the concomittant use of a real time frequency analyzer along with a continuous wave carotid Doppler scanner is demonstrated in this study of 118 cases. With a colour-coded Doppler scanner alone, internal carotid stenoses greater than 35% were diagnosed with a sensitivity of 95% and a specificity of 82%. W...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.13.5.660

    authors: Johnston KW,Brown PM,Kassam M

    更新日期:1982-09-01 00:00:00

  • Cognitive behavioral psychotherapy for depression following stroke: a randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:There is inconclusive evidence of the effectiveness of psychological interventions for depression after stroke. We report the results from a randomized controlled trial of cognitive behavioral therapy (CBT). METHODS:Stroke patients admitted to hospital were invited to complete mood questionnaire...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.0000044167.44670.55

    authors: Lincoln NB,Flannaghan T

    更新日期:2003-01-01 00:00:00

  • Thrombosis in a congenitally bifurcated superior sagittal sinus.

    abstract::A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The initial thrombus was present only in the right channel of a congenitally bifurcated superior sagittal sinus. This diagnosis and subsequent thrombus extension were readily shown by magnetic resonance imaging in contrast...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.22.3.396

    authors: Hosley MA,Fisher M,Lingley JF

    更新日期:1991-03-01 00:00:00

  • Reduction in incident stroke risk with vigorous physical activity: evidence from 7.7-year follow-up of the national runners' health study.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess the dose-response relationship between vigorous physical activity (running distance, km/d) and the participant-reported physician-diagnosed stroke. METHODS:Age-adjusted survival analysis of 29 279 men and 12 123 women followed prospectively for 7.7 years. ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.535427

    authors: Williams PT

    更新日期:2009-05-01 00:00:00

  • Validation of Wall Enhancement as a New Imaging Biomarker of Unruptured Cerebral Aneurysm.

    abstract::Background and Purpose- High-resolution vessel wall magnetic resonance imaging is a promising technique for assessing wall structures of unruptured intracranial aneurysms (UIAs). However, the relationship between aneurysmal high-resolution vessel wall magnetic resonance imaging features and their histopathologic mecha...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.024195

    authors: Quan K,Song J,Yang Z,Wang D,An Q,Huang L,Liu P,Li P,Tian Y,Zhou L,Zhu W

    更新日期:2019-06-01 00:00:00

  • Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke.

    abstract:BACKGROUND AND PURPOSE:Leukocytes contribute to cerebral ischemia-reperfusion injury. However, few experimental models examine both in vivo behavior of leukocytes and microvascular rheology after stroke. The purpose of the present study was to characterize patterns of leukocyte accumulation in the cerebral microcircula...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.5.1153

    authors: Ritter LS,Orozco JA,Coull BM,McDonagh PF,Rosenblum WI

    更新日期:2000-05-01 00:00:00

  • Significance of EEG changes at carotid endarterectomy.

    abstract::Visually apparent EEG changes associated with clamping the internal carotid artery appeared in 55 of 176 consecutive patients (31%) undergoing carotid endarterectomy without shunt. Attenuation of higher frequency activity was the most common change. Changes were moderate in 33 patients (19%) and major in 22 (12.5%). M...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.5.891

    authors: Blume WT,Ferguson GG,McNeill DK

    更新日期:1986-09-01 00:00:00

  • Factors influencing the frequency of fluorescence transients as markers of peri-infarct depolarizations in focal cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:Peri-infarct depolarizations (PIDs) that occur in ischemic boundary zones of the cerebral cortex of experimental animals have been shown to promote rather than simply to indicate the evolution of the lesion and are especially prominent in the rat. To study the influence of one factor, species, on...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.1.214

    authors: Strong AJ,Smith SE,Whittington DJ,Meldrum BS,Parsons AA,Krupinski J,Hunter AJ,Patel S,Robertson C

    更新日期:2000-01-01 00:00:00

  • Effects of formaldehyde fixation on basilar artery caliber.

    abstract::The external diameters of rat and rabbit basilar arteries were determined before and after formaldehyde fixation in relaxed and drug constricted vessels. Fixation usually resulted in an immediate vessel constriction followed by partial relaxation after several hours. However, the results were inconstant from vessel to...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.11.1.99

    authors: Hart MN,O'Donnell SL

    更新日期:1980-01-01 00:00:00

  • Overexpression of CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction.

    abstract:BACKGROUND AND PURPOSE:Inflammation is thought to be a major contributor to carotid artery disease. Lipopolysaccharide (LPS) activates inflammatory mechanisms thought to contribute to endothelial dysfunction by mechanisms that are not well defined. The goal of this study was to determine whether overexpression of CuZn-...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000132764.06878.c5

    authors: Didion SP,Kinzenbaw DA,Fegan PE,Didion LA,Faraci FM

    更新日期:2004-08-01 00:00:00

  • Trends in fatal and nonfatal strokes among persons aged 35 to > or =85 years during 1991-2002 in Finland.

    abstract:BACKGROUND AND PURPOSE:Declining trends in the incidence and mortality of stroke have been observed in Finland since the beginning of the 1980s until 1997. In this study we analyzed the trends in fatal and nonfatal strokes in Finland during 1991-2002. METHODS:The Finnish Hospital Discharge Register was linked to the N...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000152945.28543.4a

    authors: Pajunen P,Pääkkönen R,Hämäläinen H,Keskimäki I,Laatikainen T,Niemi M,Rintanen H,Salomaa V

    更新日期:2005-02-01 00:00:00

  • Nitric oxide regulates cerebral arteriolar tone in rats.

    abstract:BACKGROUND AND PURPOSE:Although cerebral penetrating arterioles are main regulators of the brain microcirculation, little is known about the effect of endothelium-derived relaxation factor on these vessels. This study examined the effects of nitric oxide synthase inhibitors on the spontaneous tone of isolated rat cereb...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.11.2227

    authors: Kimura M,Dietrich HH,Dacey RG Jr

    更新日期:1994-11-01 00:00:00

  • Lifestyle factors and risk of cerebral infarction.

    abstract:BACKGROUND AND PURPOSE:We evaluated the impact of lifestyle factors on the risk of ischemic stroke. METHODS:We used a nested case-control design. The cases comprised 163 persons (median age 69 years) admitted to a stroke unit and diagnosed with acute cerebral infarction. All cases had earlier participated in the North...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.6.829

    authors: Ellekjaer EF,Wyller TB,Sverre JM,Holmen J

    更新日期:1992-06-01 00:00:00

  • Lack of evolution of the cerebral blood flow during clinical recovery of a stroke.

    abstract::Cerebral blood flow and clinical parameters were studied in 30 stroke patients at 15th, 30th, 60th, 90th days after the cerebral insult (Xenon 133 inhalation method). The clinical improvement was not accompanied by a progressive normalization of the CBF at rest. No relationship was found between the clinical data and ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.1.77

    authors: Demeurisse G,Verhas M,Capon A,Paternot J

    更新日期:1983-01-01 00:00:00

  • A prospective study of cerebral ischemia in the young. Analysis of pathogenic determinants. The National Research Council Study Group.

    abstract:BACKGROUND AND PURPOSE:The etiology of stroke in the young is different from that in older patients and remains unknown in almost one third of the cases. To gain further insight into both pathogenic and etiologic determinants, we prospectively studied a large number of consecutive young adults with focal cerebral ische...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.3.362

    authors: Carolei A,Marini C,Ferranti E,Frontoni M,Prencipe M,Fieschi C

    更新日期:1993-03-01 00:00:00

  • Comparison of computed tomographic and magnetic resonance perfusion measurements in acute ischemic stroke: back-to-back quantitative analysis.

    abstract:BACKGROUND AND PURPOSE:Magnetic resonance perfusion (MRP) and computed tomographic perfusion (CTP) are being increasingly applied in acute stroke trials and clinical practice, yet the comparability of their perfusion values is not well validated. The aim of this study was to validate the comparability of CTP and MRP me...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.114.005419

    authors: Lin L,Bivard A,Levi CR,Parsons MW

    更新日期:2014-06-01 00:00:00

  • Anticoagulation Use and Clinical Outcomes After Major Bleeding on Dabigatran or Warfarin in Atrial Fibrillation.

    abstract:BACKGROUND AND PURPOSE:Little is known about the clinical outcomes associated with posthemorrhage anticoagulation resumption for atrial fibrillation. This study had 2 objectives: first, to evaluate anticoagulation use after a first major bleed on warfarin or dabigatran and, second, to compare effectiveness and safety o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.015150

    authors: Hernandez I,Zhang Y,Brooks MM,Chin PK,Saba S

    更新日期:2017-01-01 00:00:00

  • Studies on cerebral blood flow and oxygen metabolism in patients with established cerebral infarcts undergoing omental transposition.

    abstract::Regional cerebral blood flow, blood volume, fractional oxygen extraction, and oxygen consumption were measured by positron emission tomography in 4 stroke patients prior to and 6 months following omental transposition surgery. Preoperatively, 3 patients showed the typical picture of established infarction with a match...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.18.1.46

    authors: Herold S,Frackowiak RS,Neil-Dwyer G

    更新日期:1987-01-01 00:00:00

  • Rehabilitation outcome following initial unilateral hemispheric stroke. Life table analysis approach.

    abstract::Life table analysis is a powerful statistical tool that has become the preferred technique for studying both the natural history of and the effect of treatment on disease outcome. We have found only one report using life table analysis to study rehabilitation outcome after stroke. We assessed the recovery of both inde...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.11.1354

    authors: Reding MJ,Potes E

    更新日期:1988-11-01 00:00:00

  • MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia.

    abstract:BACKGROUND AND PURPOSE:The objectives of the present study were to: (1) noninvasively identify white matter reorganization and monitor its progress within 6 weeks after the onset of stroke; and (2) quantitatively investigate the effect of recombinant human erythropoietin treatment on this structural change using in viv...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.527713

    authors: Li L,Jiang Q,Ding G,Zhang L,Zhang ZG,Li Q,Panda S,Kapke A,Lu M,Ewing JR,Chopp M

    更新日期:2009-03-01 00:00:00

  • Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease.

    abstract:BACKGROUND AND PURPOSE:Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensiti...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.564914

    authors: Doubal FN,MacLullich AM,Ferguson KJ,Dennis MS,Wardlaw JM

    更新日期:2010-03-01 00:00:00

  • Stent placement in acute cerebral artery occlusion: use of a self-expandable intracranial stent for acute stroke treatment.

    abstract:BACKGROUND AND PURPOSE:Stent placement has been applied in small case series as a rescue therapy in combination with different thrombolytic agents, percutaneous balloon angioplasty (PTA), and mechanical thromboembolectomy (MT) in acute stroke treatment. These studies report a considerable mortality and a high rate of i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.533810

    authors: Brekenfeld C,Schroth G,Mattle HP,Do DD,Remonda L,Mordasini P,Arnold M,Nedeltchev K,Meier N,Gralla J

    更新日期:2009-03-01 00:00:00