Abstract:
BACKGROUND AND PURPOSE:The present investigation aimed to quantify functional activity in rat brains after long-term recovery from transient forebrain ischemia. METHODS:With the use of the [14C]2-deoxyglucose method, local cerebral glucose utilization was measured in 62 cortical and subcortical brain regions in postischemic rat brains. Transient forebrain ischemia of 10 minutes' duration was induced by clamping the common carotid arteries and simultaneously lowering blood pressure to 40 mm Hg. Rats survived the insults for 1 week, 2 weeks, 3 weeks, or 3 months. RESULTS:Reductions predominated in the majority of gray matter structures at all time points investigated (P < .05). Except for a few areas, recoveries of local cerebral glucose utilization to preischemic levels did not occur. CONCLUSIONS:The data illustrate that widespread alterations of functional activity prevail in postischemic brains beyond the selectively vulnerable regions. The present functional data are in line with previous stereological results of reduced fresh volumes in the majority of postischemic brain structures. The data suggest that chronic alterations of ischemic brains are not confined to the selectively vulnerable regions.
journal_name
Strokejournal_title
Strokeauthors
Beck T,Goller HJ,Wree Adoi
10.1161/01.str.26.6.1107subject
Has Abstractpub_date
1995-06-01 00:00:00pages
1107-13issue
6eissn
0039-2499issn
1524-4628journal_volume
26pub_type
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