Chronic depression of glucose metabolism in postischemic rat brains.

Abstract:

BACKGROUND AND PURPOSE:The present investigation aimed to quantify functional activity in rat brains after long-term recovery from transient forebrain ischemia. METHODS:With the use of the [14C]2-deoxyglucose method, local cerebral glucose utilization was measured in 62 cortical and subcortical brain regions in postischemic rat brains. Transient forebrain ischemia of 10 minutes' duration was induced by clamping the common carotid arteries and simultaneously lowering blood pressure to 40 mm Hg. Rats survived the insults for 1 week, 2 weeks, 3 weeks, or 3 months. RESULTS:Reductions predominated in the majority of gray matter structures at all time points investigated (P < .05). Except for a few areas, recoveries of local cerebral glucose utilization to preischemic levels did not occur. CONCLUSIONS:The data illustrate that widespread alterations of functional activity prevail in postischemic brains beyond the selectively vulnerable regions. The present functional data are in line with previous stereological results of reduced fresh volumes in the majority of postischemic brain structures. The data suggest that chronic alterations of ischemic brains are not confined to the selectively vulnerable regions.

journal_name

Stroke

journal_title

Stroke

authors

Beck T,Goller HJ,Wree A

doi

10.1161/01.str.26.6.1107

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

1107-13

issue

6

eissn

0039-2499

issn

1524-4628

journal_volume

26

pub_type

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