Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki Birth Cohort Study (HBCS).

abstract：:Alcoholism is a complex disorder involving both genetic and environmental factors and interactions between them. Localizing and characterizing the genetic influences on susceptibility to alcohol dependence may provide new insights into pathology and new avenues for treatment and prevention. However, because of the com...

journal_title：Annals of medicine

authors： Almasy L

更新日期：2003-01-01 00:00:00

abstract：:Regenerative medicine is a multidisciplinary field utilizing the potential of stem cells and the regenerative capability of the body to restore, maintain, or enhance tissue and organ functions. Stem cells are unspecialized cells that can self-renew but also differentiate into several somatic cells when subjected the a...

journal_title：Annals of medicine

authors： Kaivosoja E,Barreto G,Levón K,Virtanen S,Ainola M,Konttinen YT

更新日期：2012-11-01 00:00:00

abstract：:The circadian clock generates oscillations in physiology and behavior, known as circadian rhythms. Links between the circadian clock genes Periods, Bmal1, and Cryptochromes and aging and cancer are emerging. Circadian clock gene expression is changed in human pathologies, and transgenic mice with mutations in clock ge...

journal_title：Annals of medicine

authors： Khapre RV,Samsa WE,Kondratov RV

更新日期：2010-09-01 00:00:00

abstract：:Atrial fibrillation (AF) is associated with an increased risk of mortality and morbidity from stroke and thromboembolism. Endothelial damage or dysfunction may contribute to this increased risk of thromboembolism via the mediation of a prothrombotic or hypercoagulable state. However, the precise pathophysiological mec...

journal_title：Annals of medicine

authors： Krishnamoorthy S,Lim SH,Lip GY

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:Rapid weight loss with very-low-calorie diet (VLCD) is known to improve insulin sensitivity and decrease adipose tissue masses. The aim was to investigate the effects of VLCD on adipose tissue regional glucose uptake (rGU) and perfusion and their association with adipokines. RESEARCH DESIGN AND METHODS:Sixte...

journal_title：Annals of medicine

authors： Viljanen AP,Lautamäki R,Järvisalo M,Parkkola R,Huupponen R,Lehtimäki T,Rönnemaa T,Raitakari OT,Iozzo P,Nuutila P

更新日期：2009-01-01 00:00:00

abstract：:Troglitazone is a novel once-daily oral antidiabetic agent for the treatment of type 2 diabetes patients. Here, we report the overall dose response characteristics of troglitazone, with respect to effects on metabolic control, using a pharmacodynamic model. Data from week 12 from two previously reported double-blind, ...

journal_title：Annals of medicine

authors： Young MA,Eckland DJ,Eastmond R,Lettis S

更新日期：1998-04-01 00:00:00

abstract：:This paper reviews current diagnostic techniques for Helicobacter pylori infection and critically questions their value under different diagnostic circumstances. As long as we do not have general treatment recommendations for H. pylori infection, endoscopy is still the basis for primary diagnosis because it assesses t...

journal_title：Annals of medicine

authors： Braden B,Caspary WF

更新日期：2001-03-01 00:00:00

abstract：AIM:To evaluate dyslipidemia as predictor of myocardial infarction (MI) in subjects with or without chronic kidney disease (CKD). METHODS:In 142,394 middle-aged Swedes referred for laboratory evaluation, glomerular filtration rates (GFR) were estimated using the Modification of Diet in Renal Disease study equation. CK...

journal_title：Annals of medicine

authors： Holzmann MJ,Jungner I,Walldius G,Ivert T,Nordqvist T,Ostergren J,Hammar N

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Teriparatide is a potent anabolic agent for severe osteoporosis. OBJECTIVES:A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. METHODS:The patient population comprises 119 os...

journal_title：Annals of medicine

authors： Koski AM,Löyttyniemi E,Väänänen H,Laine H,Niskanen L,Nevalainen PI,Korpi-Hyövälti E,Välimäki MJ

更新日期：2013-05-01 00:00:00

abstract：:Certain bacterial infections have been demonstrated to be causative of reactive arthritis. The most common bacterial trigger of reactive arthritis is Chlamydia trachomatis. Chlamydia pneumoniae is another known cause, albeit far less frequently. Although Chlamydia-induced reactive arthritis will often spontaneously re...

journal_title：Annals of medicine

authors： Carter JD,Inman RD,Whittum-Hudson J,Hudson AP

更新日期：2012-12-01 00:00:00

abstract：:This study examined the predictive validity of preadolescent Type A determinants for Type A dimensions in young adulthood (n = 375). Predictive variables, i.e. hyperactivity, aggression, social maladjustment and self-esteem were measured when the subjects were aged 12. Type A dimensions, i.e. hard-driving, competitive...

journal_title：Annals of medicine

authors： Keltikangas-Järvinen L,Räikkönen K,Keskivaara P,Pietikäinen M,Viikari J,Kaprio EA,Akerblom HK

更新日期：1991-02-01 00:00:00

abstract：:Mitochondria provide cells with most of the energy in the form of adenosine triphosphate (ATP). Mitochondria are complex organelles encoded both by nuclear and mtDNA. Only a few mitochondrial components are encoded by mtDNA, most of the mt-proteins are nuclear DNA encoded. Remarkably, the majority of the known mutatio...

journal_title：Annals of medicine

authors： Maassen JA,Janssen GM,'t Hart LM

更新日期：2005-01-01 00:00:00

abstract：:Despite the monumental success of childhood prophylactic vaccination, there is no similar program designed to provide protection as we age against adult onset diseases like breast cancer. Instead, the predominant focus of current cancer vaccine strategy is to vaccinate after the tumors become established. This strateg...

journal_title：Annals of medicine

authors： Tuohy VK,Jaini R

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Finnish type of hereditary gelsolin amyloidosis (FGA) is one of the most common diseases of Finnish disease heritage. Existing FGA knowledge is based only on smaller patient series, so our aim was to elucidate the natural course of the disease in a comprehensive sample of patients and to build up a national ...

journal_title：Annals of medicine

authors： Nikoskinen T,Schmidt EK,Strbian D,Kiuru-Enari S,Atula S

更新日期：2015-01-01 00:00:00

abstract：:Antisense oligonucleotides represent a novel class of potential drugs for highly selective blocking of genes. The basic concept of antisense strategy is simple: an antisense molecule recognizes a complementary mRNA (or DNA) by sequence-specific base pairing, and hence prevents translation (or transcription), resulting...

journal_title：Annals of medicine

authors： Lönnberg H,Vuorio E

更新日期：1996-12-01 00:00:00

abstract：:The thoracolumbar junctional region (T10-L1) of the spine is a transitional zone, where more than half of the thoracic and lumbar fractures occur. In this presentation the origin of the pathoanatomical changes in the thoracolumbar junctional region of the spine is discussed in view of the previous studies. These studi...

journal_title：Annals of medicine

authors： Malmivaara AO

更新日期：1989-10-01 00:00:00

abstract：:Abstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by m...

journal_title：Annals of medicine

authors： Rigante D,Cantarini L,Imazio M,Lucherini OM,Sacco E,Galeazzi M,Brizi MG,Brucato A

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Multiple lines of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD). We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, pr...

journal_title：Annals of medicine

authors： Partonen T,Treutlein J,Alpman A,Frank J,Johansson C,Depner M,Aron L,Rietschel M,Wellek S,Soronen P,Paunio T,Koch A,Chen P,Lathrop M,Adolfsson R,Persson ML,Kasper S,Schalling M,Peltonen L,Schumann G

更新日期：2007-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with an increased risk of ischemic stroke (IS) and systemic embolism (SE). Stroke prevention is a key element for the overall management of AF patients. The non-vitamin K antagonist oral anticoagulants (NOACs), such as dabigatran, rivaroxaban,...

journal_title：Annals of medicine

authors： Li YG,Pastori D,Lip GYH

更新日期：2018-06-01 00:00:00

abstract：:Thymoma is an unusual tumour, but it is the most common malignancy in the anterior mediastinum. This tumour is unique in its frequent association with paraneoplastic syndrome and its potential for indolent growth. The distinction between thymomas and other tumours which arise in the anterior or superior mediastinum is...

journal_title：Annals of medicine

authors： Loehrer PJ Sr

更新日期：1999-10-01 00:00:00

abstract：:Insulin resistance in humans is not always accompanied by obesity, since severe insulin resistance also characterizes patients lacking subcutaneous fat such as those with HAART- (highly-active antiretroviral therapy)-associated lipodystrophy. Both obese and lipodystrophic patients, however, have an increase in the amo...

journal_title：Annals of medicine

authors： Yki-Järvinen H

更新日期：2005-01-01 00:00:00

abstract：:In the aetiological diagnosis of pulmonary infections in patients affected by haematological malignancies we evaluated the utility of bronchoalveolar lavage (BAL). One hundred and twenty-seven BAL were performed in 119 patients. In our series, we identified the agent of pneumonia in 53.5% of episodes with the best res...

journal_title：Annals of medicine

authors： Pagano L,Pagliari G,Basso A,Marra R,Sica S,Frigieri L,Morace G,Ardito F,Leone G

更新日期：1997-12-01 00:00:00

abstract：:A 33-year old man suddenly dropped dead during a military march. He had complained of non-specific thoracoabdominal symptoms, pain and fatigue for a year before his death. Autopsy showed coronary polyarteritis nodosa of the left main coronary artery. This patient seems to be only the second case with isolated polyarte...

journal_title：Annals of medicine

authors： Paul RA,Helle MJ,Tarssanen LT

更新日期：1990-06-01 00:00:00

abstract：:We evaluated the reliability hospital discharge register data in the assessment of acute myocardial infarction trends. In the FINMONICA study areas, trends in age standarized attack rates for the years 1983-90 were calculated independently from two sources: the nationwide Finnish hospital discharge register and the FI...

journal_title：Annals of medicine

authors： Mähönen M,Miettinen H,Pyörälä K,Molarius A,Salomaa V,Kuulasmaa K

更新日期：1995-10-01 00:00:00

abstract：:Non-alcoholic fatty liver disease or NAFLD is a chronic liver condition characterized by hepatic steatosis and associated with insulin resistance and type 2 diabetes mellitus (T2DM). In many patients fat accumulation leads to steatohepatitis (NASH) with chronic necrosis, inflammation, and fibrosis, and eventually to t...

journal_title：Annals of medicine

authors： Ali R,Cusi K

更新日期：2009-01-01 00:00:00

abstract：:Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects. Examples of the dose-dependent effects include the antiglucocorticoid effects of RU 486, whereas pregnancy termination or dilatation of the cervix can be considered dose-independent with the va...

journal_title：Annals of medicine

authors： Heikinheimo O,Kekkonen R

更新日期：1993-02-01 00:00:00

abstract：:The risk of cardiovascular disease is markedly increased in patients with type 2 diabetes with a prevalence twice as high compared to the background population. With the recognition of multiple concomitant risk factors for both microvascular as well as cardiovascular disease in type 2 diabetic patients, treatment stra...

journal_title：Annals of medicine

authors： Gaede P,Pedersen O

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people. PATIENTS AND METHODS:Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS:A total of 375 ...

journal_title：Annals of medicine

authors： González Silva Y,Abad Manteca L,de la Red Gallego H,Álvarez Muñoz M,Rodríguez Carbajo M,Murcia Casado T,Ausín Pérez L,Abadía Otero J,Pérez-Castrillón JL

更新日期：2018-09-01 00:00:00

abstract：:The phenomenon of treatment-resistant depression (TRD), described as the occurrence of an inadequate response after an adequate treatment with antidepressant agents (in terms of dose, duration, and adherence), is very common in clinical practice. It has been broadly defined in the context of unipolar major depression,...

journal_title：Annals of medicine

authors： Vieta E,Colom F

更新日期：2011-11-01 00:00:00

abstract：:We investigated the association of systolic and diastolic blood pressure and hypertension with two different manifestations of carotid atherosclerosis in a random population sample of 1165 Eastern Finnish men aged 42, 48, 54 or 60 years, examined in the Kuopio Ischaemic Heart Disease Risk Factor Study. Carotid atheros...

journal_title：Annals of medicine

authors： Salonen R,Salonen JT

更新日期：1991-02-01 00:00:00