Abstract：
:Bipolar disorder is associated with decreased quality of life, especially during depressive episodes. There are few studies that have examined whether quality of life improves following pharmacological treatments of bipolar depression. In this exploratory study, we examined the effects of antidepressant versus mood stabilizer monotherapy on quality of life ratings in bipolar II subjects during acute (12 week) treatment. Data were derived from a randomized double-blind comparison of venlafaxine (n = 65) versus lithium (n = 64) monotherapy. The Quality of Life Index (QLI) was administered at baseline (n = 126; 98%) and again at the end of treatment. We explored treatment differences in continuous changes on the QLI using last-observation carried forward. Additionally, we explored the likelihood of experiencing clinically-significant improvements as well as baseline correlates of QLI and changes in QLIe. Venlafaxine was superior to lithium in reducing symptoms of depression during acute treatment. However, there were no significant differences between treatments in QLI ratings. Changes in symptoms of depression were correlated to, but not redundant, with improvements in QLI ratings. These findings suggest that quality of life may be an important secondary outcome to target and measure as a part of comparative clinical trials of pharmacotherapy for bipolar II depression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Lorenzo-Luaces L,Amsterdam JDdoi
10.1016/j.psychres.2017.11.025subject
Has Abstractpub_date
2018-01-01 00:00:00pages
455-459eissn
0165-1781issn
1872-7123pii
S0165-1781(17)31617-7journal_volume
259pub_type
杂志文章,随机对照试验abstract：:Modest alcohol and aggressive trait effects on laboratory-induced aggression among men have been reported with some consistency in the literature. Relationships between aggressive personality traits and laboratory-induced aggression appear to become less consistent under the influence of alcohol. Several research team...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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pub_type： 杂志文章
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