Abstract:
:Endovascular acute ischemic stroke therapy is now proven by randomized controlled trials to produce large, clinically meaningful benefits. In response, stroke systems of care must change to increase timely and equitable access to this therapy. In this review, we provide a North American perspective on implications for stroke systems, focusing on the United States and Canada, accompanied by initial recommendations for changes. Most urgently, every community must create access to a hospital that can safely and quickly provide intravenous tissue-type plasminogen activator and immediately transfer appropriate patients onward to a more capable center as required. Safe and effective therapy in the community setting will be ensured by certification programs, performance measurement, and data entry into registries.
journal_name
Strokejournal_title
Strokeauthors
Smith EE,Schwamm LHdoi
10.1161/STROKEAHA.115.008385subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1462-7issue
6eissn
0039-2499issn
1524-4628pii
STROKEAHA.115.008385journal_volume
46pub_type
杂志文章,评审相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Despite the social, health, and economic burdens associated with cognitive impairment poststroke, there is considerable uncertainty about the types of interventions that might preserve or restore cognitive abilities. The objective of this systematic review and meta-analysis was to evaluate the ef...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.117.017319
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Indications for carotid endarterectomy have engendered considerable debate among experts and have resulted in publication of retrospective reviews, natural history studies, audits of community practice, position papers, expert opinion statements, and finally prospective randomized trials. The Ame...
journal_title:Stroke
pub_type: 共识发展会议,指南,杂志文章,实务指引,评审
doi:10.1161/01.str.26.1.188
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of athersclerosis in the difference between the pathogenesis of large-vessel disease (LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patie...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000260220.37016.88
更新日期:2007-04-01 00:00:00
abstract::Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.6.1022
更新日期:1985-11-01 00:00:00
abstract::Background and Purpose- The use of oral anticoagulants (OAC) is considered a contra-indication for intravenous thrombolytics as acute treatment of ischemic stroke. However, little is known about the risks and benefits of endovascular treatment in patients on prior OAC. We aim to compare outcomes after endovascular tre...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.119.028675
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown. METHODS:we genotyped single nucleotide polymorphisms (...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.591230
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Aphasia can result in an inability to communicate the presence, location, or intensity of pain. Although visual analogue scales (VASs) exist, it is unknown whether they are useful in assessing pain in individuals with aphasia. The objective was to determine whether those with poststroke aphasia c...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000198872.75377.34
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Silent cerebrovascular disease (CVD) has been proposed as a predisposing condition for clinically overt stroke and vascular dementia. Recently, we found increased thrombin generation in silent CVD patients. Here, we report the effect of thrombin inhibition using a potent selective thrombin inhibi...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.30.5.1033
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The use of thrombolysis in acute minor ischemic stroke (MIS) remains controversial. We sought to determine the safety and efficacy of intravenous tissue-type plasminogen activator (IV-tPA) in acute MIS patients with demonstrable penumbra on computed tomographic perfusion study. METHODS:Consecuti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013021
更新日期:2016-07-01 00:00:00
abstract::We used 44 splenectomized dogs to study the effects of isovolemic hemodilution with a crystalloid solution. The dogs were randomly divided into a hemodilution and a control group. In each group, 17 dogs were subjected to 6 hours of internal carotid and middle cerebral artery occlusion, and five dogs received sham oper...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.4.534
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several hundred studies have been published over the last few years on imaging and measurement of carotid stenosis. Despite all this research, there is still no consensus about how best to image and measure stenosis. One possible explanation for this is that many of the studies have not been larg...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.31.6.1444
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We compared among young patients with ischemic stroke the distribution of vascular risk factors among sex, age groups, and 3 distinct geographic regions in Europe. METHODS:We included patients with first-ever ischemic stroke aged 15 to 49 years from existing hospital- or population-based prospec...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.112.662866
更新日期:2012-10-01 00:00:00
abstract::Perioperative cerebral infarction occurs in less than 1% of general surgical procedures; the mechanism is usually unknown. The clinical features of 12 consecutive perioperative strokes were retrospectively reviewed. Although intraoperative hypotension was frequent, onset of deficit occurred postoperatively in 83% and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.6.766
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To investigate whether neuroimaging information has added predictive value compared with clinical information for independency in activities of daily living (ADL) 1 year after stroke. METHODS:Seventy-five first-ever middle cerebral artery stroke survivors were evaluated in logistic regression an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000206462.09410.6f
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Findings on transesophageal echocardiography (TEE) after ischemic stroke predict recurrent embolic events and prompt therapy; however, the additive predictive power of TEE findings on long-term mortality is unknown. Our goal was to study the impact of TEE findings on all cause mortality in ischem...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000196939.12313.16
更新日期:2006-01-01 00:00:00
abstract::Naloxone has been reported to have potential benefit in the treatment of stroke. We evaluated the effect of naloxone in a double-blind trial conducted with 15 stroke patients whose deficits ranged from 8 to 60 hours in duration. All but one patient sustained a cerebral infarction. Neurologic function was assessed befo...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.15.4.627
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Computed tomography (CT) is used to study coronary artery plaques, but little is known about its potential to characterize plaque composition. This study assesses the relation between carotid calcium score (CCS) by CT and plaque composition, namely extracellular matrix, inflammatory mediators, an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.620658
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous work has shown that cerebral microembolism detected with transcranial Doppler sonography distal to internal carotid artery stenosis occurs more frequently in recently symptomatic compared with asymptomatic patients. It has remained unclear whether cerebral microembolism also indicates a ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.11.2184
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Treatment of intracerebral hematoma (ICH) is controversial. An advantage of neurosurgical intervention over conservative treatment of ICH has not been established. Recent reports suggest a favorable effect of stereotactic blood clot removal after liquefaction by means of a plasminogen activator. ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.STR.0000063367.52044.40
更新日期:2003-04-01 00:00:00
abstract::Regional cerebral ischemia was produced by common carotid artery occlusion in gerbils and by middle cerebral artery occlusion in dogs, cats, and squirrel monkeys. Anesthesia was induced with either pentobarbital or halothane and maintained for two to three hours after vessel occlusion. In acute studies, the effect of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.6.4.405
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Loss of movement coordination is the main postacute symptom after cerebellar infarction. Although the course of motor recovery has been described previously, detailed kinematic descriptions of acute stage ataxia are rare and no attempt has been made to link improvements in motor function to measu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.583641
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Physiologically, it appears plausible for physical activity to decrease stroke risk; however, epidemiological studies have produced mixed findings. Furthermore, few studies have examined specific kinds and intensities of activities. The purpose of this study was to examine the association between...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.10.2049
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to examine the relationship between depressive symptoms and the incidence of stroke among Japanese men and women. METHODS:A 10.3-year prospective study on the relationship between depressive symptoms and the incidence of stroke was conducted with 901 men and women aged 40 to 78 years i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.4.903
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is a major healthcare problem in both the United States (US) and the United Kingdom (UK). Little comparative data are available concerning how generalist physicians in the two countries approach the management of patients at high risk of stroke. METHODS:Contemporaneous surveys of random s...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.4.746
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The effect of tissue-type plasminogen activator on functional outcome decreases progressively over time. However, given the differential pattern of arterial occlusion, stroke severity, and speed of ischemic lesion growth among candidates for reperfusion, the time window should be adjusted accordi...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.113.004307
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study was to investigate the periprocedural morbidity, mortality, and long-term clinical and angiographic follow-up using stent-assisted coiling and stenting alone for treatment of cranial fusiform dissecting and atherosclerotic aneurysms. METHODS:The Institutional Review Boa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.512996
更新日期:2008-12-01 00:00:00
abstract::A woman who presented with a subarachnoid hemorrhage secondary to a ruptured anterior spinal artery aneurysm of the spinal cord is reported. While this is the first report of a ruptured aneurysm of the anterior spinal artery with angiographic confirmation, it emphasizes that occasionally subarachnoid hemorrhage may be...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.12.2.230
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Current US guideline statements regarding primary and secondary cardiovascular risk prediction and prevention use absolute risk estimates to identify patients who are at high risk for vascular disease events and who may benefit from specific preventive interventions. These guidelines do not expli...
journal_title:Stroke
pub_type: 杂志文章,实务指引
doi:10.1161/STR.0b013e31825bcdac
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To identify if the stroke-prone spontaneously hypertensive rat (SHRSP) exhibits impaired functional recovery after stroke compared with its normotensive reference strain, the Wistar Kyoto rat (WKY). METHODS:In study 1, a 2-mm distal middle cerebral artery occlusion (middle cerebral artery occlus...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000149629.32525.b7
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.2074
更新日期:1993-12-01 00:00:00