Abstract：
:Triatoma infestans is a mandatory haematophagous vector of Chagas disease in Brazil. Despite a large number of studies on the anti-haemostatic molecules present in its saliva, the role of its salivary components on parasite transmission is poorly understood. Here, we show that the bioactive lipid molecule, lysophosphatidylcholine (LPC), is present in the salivary gland of T. infestans. We characterized the lipid profiles of each unit of the T. infestans salivary gland. We noticed that LPC is present in the three units of the salivary gland and that the insect feeding state does not influence its proportion. T. infestans saliva and LPC can enhance T. cruzi transmission to mice by dramatically altering the profile of inflammatory cells at the site of inoculation on mouse skin, facilitating the transmission of T. cruzi to the vertebrate host. Consequently, the mortality curves of either saliva- or LPC-injected mice display significant higher mortality rates than the control. Altogether, these results implicate LPC as one of key salivary molecule involved in Chagas disease transmission.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Lima MS,Carneiro AB,Souto-Padron T,Jurberg J,Silva-Neto MAC,Atella GCdoi
10.1016/j.actatropica.2017.10.022subject
Has Abstractpub_date
2018-02-01 00:00:00pages
68-72eissn
0001-706Xissn
1873-6254pii
S0001-706X(17)30711-8journal_volume
178pub_type
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