Abstract:
:The paper summarizes the evolution of a biomedical field research station in Tanzania, established by a European institute, into a national health research and resource centre. The Swiss Tropical Institute Field Laboratory was founded in Ifakara in the Kilombero District in southeastern Tanzania in 1957. It has evolved into the Ifakara Centre, a national but peripherally located research centre involved in applied, operational and health systems research, training, and direct health sector support activities. Since 1991, the centre has been an affiliate of the National Institute for Medical Research in Tanzania. It has achieved an autonomous status and attracts frontline priority research and high quality research teams; the ongoing phase 3 malaria vaccine trial is a recent major activity. Starting from biomedical priorities in research and training, the centre has broadened its spectrum to include social science disciplines including economics. The major determinants for this development were (i) the long-term partnership between the executing agency in the north and the partners in the south at the national level, (ii) the support of this partnership by a long-term commitment of the major funding partners, (iii) the concept that local priorities form the basis of all activities, and (iv) the linking of research and training to public health action. The last two elements are considered to be crucial for the centre's multidisciplinary approach to health research and the support of public health in Tanzania and in eastern and southern Africa.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Tanner M,Kitua A,Degrémont AAdoi
10.1016/0001-706x(94)90006-xsubject
Has Abstractpub_date
1994-08-01 00:00:00pages
153-73issue
2-3eissn
0001-706Xissn
1873-6254pii
0001-706X(94)90006-Xjournal_volume
57pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract::In history disease has caused social and economic damage. Dengue is an illness typically found in the tropics that has affected more and more people. In Brazil, according to the Brazilian Institute of Geography and Statistics (IBGE), in 2013 at least 12.9% of the population (25.8 million) reported already having had d...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2017.11.016
更新日期:2018-02-01 00:00:00
abstract::We examined the malaria situation among 489 children under 5 years of age in the rural villages of Aboh Mbaise, Nigeria, using a combination of a standard questionnaire technique and laboratory diagnosis to confirm clinical observations. The results show a high prevalence rate of 52.8% for Plasmodium falciparum in thi...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/0001-706x(90)90061-4
更新日期:1990-10-01 00:00:00
abstract::Two PCR methods were compared for their sensitivity in detecting cultured Leishmania major, before being used to estimate infection rates in female sandflies (Phlebotomus papatasi) collected from peridomestic animal shelters and the nearby burrows of the gerbil reservoir hosts, Rhombomys opimus, in Isfahan province, c...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2004.09.007
更新日期:2005-01-01 00:00:00
abstract::A study was conducted to determine the presence of hemagglutination inhibition (HI) and neutralization antibodies against Japanese encephalitis virus (JEV) in wild pigs on an offshore island in Singapore. Blood samples were collected from 28 wild pigs on the island. All the sera tested with HI assay and plaque reducti...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(01)00212-1
更新日期:2002-03-01 00:00:00
abstract::Peripheral blood smears of 20 patients with Indian Kala-azar (KA) were collected throughout the day and night and examined for presence of Leishmania amastigotes. Amastigotes were detected in 46% of peripheral blood samples taken during the day (08:00-17:00 h) and 66% and during the night (18:00-07:00 h). This differe...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(97)00104-6
更新日期:1997-12-01 00:00:00
abstract::Visceral leishmaniasis (VL) is caused by the trypanosomatid parasite Leishmania infantum (=Leishmania chagasi), and is epidemiologically relevant due to its wide geographic distribution, the number of annual cases reported and the increase in its co-infection with HIV. Two vector species have been incriminated in the ...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2013.08.014
更新日期:2014-01-01 00:00:00
abstract::The envelope (E) protein from DENV, contain three functional and structural domains (DI, DII and DIII). Some studies suggest that neutralizing antibodies during natural DENV infection are predominantly against DI and DII, in contrast, low proportion of the antibodies were against DIII. Thus it is necessary to establis...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2017.04.006
更新日期:2017-07-01 00:00:00
abstract::Blastocystis sp. is frequently identified in a wide range of animal hosts, including bovids. Because of its burden and zoonotic potential, this parasite has been sought in domestic cattle from various countries, since this livestock may also represent a possible reservoir of human infection. However, epidemiological d...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2019.02.013
更新日期:2019-06-01 00:00:00
abstract::Malaria in pregnancy is associated with increased risks of maternal anemia, spontaneous abortion, low birth weight, premature delivery and other adverse effects on health. In Brazil, disease transmission is highly concentrated in the multi-state region that constitutes the Brazilian Amazon (more than 99% of all cases)...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2012.11.004
更新日期:2013-02-01 00:00:00
abstract::Accumulation, degradation and excretion by the host of helminth metabolic end products, such as branched-chain volatile fatty acids are poorly studied although they play an appreciable role in host-parasite interactions and, being detectable in excreta, provide a reliable diagnostic test for at least some helminthiase...
journal_title:Acta tropica
pub_type: 杂志文章
doi:
更新日期:1981-12-01 00:00:00
abstract::The Japanese Encephalitis (JE) virus circulation in Indonesia was first documented in Lombok in 1960, and the virus was first isolated in 1972 from Culex tritaeniorhynchus in Bekasi, West Java and Kapuk, West Jakarta. Since then, Indonesia has been recognized as an endemic country for JE transmission. Up to now, JE ca...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2018.08.017
更新日期:2018-11-01 00:00:00
abstract::Trypanosoma cruzi is the causative agent of Chagas disease, a zoonosis involving domestic and sylvatic mammalian reservoirs. Since scarce information has been published about the susceptibility of T. cruzi lineages to other triatomine species besides Triatoma infestans, we evaluate the susceptibility of T. infestans a...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2007.07.005
更新日期:2007-10-01 00:00:00
abstract::In July 1989, blood samples were collected from parasitaemic cattle in the Ghibe valley, Ethiopia, frozen in liquid nitrogen and transported to Nairobi, Kenya. Twelve of the stabilates were inoculated into individual Boran (Bos indicus) calves and characterised for their sensitivity, in turn, to diminazene aceturate (...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/0001-706x(93)90026-8
更新日期:1993-04-01 00:00:00
abstract::Sm14 and paramyosin are two major Schistosoma mansoni vaccine candidate antigens. Recently, we have identified Sm14 and paramyosin epitopes that are recognized by T cells of resistant individuals living in endemic areas for schistosomiasis. Herein, mice were immunized with these peptides separately or in association i...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2008.03.003
更新日期:2008-06-01 00:00:00
abstract::Vector-borne diseases (VBDs) infect over one billion people and are responsible for over one million deaths each year, globally. Chikungunya (CHIK) and Dengue Fever (DENF) are emerging VBDs due to overpopulation, increases in urbanization, climate change, and other factors. Colombia has recently experienced severe out...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2018.04.023
更新日期:2018-09-01 00:00:00
abstract::Erythrocyte survival was studied in 17 Thai patients (10 males, 7 females; aged 13-57 years) with severe falciparum malaria. To ensure radioisotopic labelling of cells before bone marrow recovery and survival analysis under near-steady state conditions, 51Cr labelling of autologous erythrocytes was performed at the ti...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/0001-706x(91)90014-b
更新日期:1991-02-01 00:00:00
abstract::Flight dispersion is recognized as one of the most important mechanisms for triatomine house infestation. Triatoma sherlocki and T. juazeirensis are closely related species that occur within the same ecotope and their possible reproductive boundaries are unknown. T. sherlocki has shorter wings than T. juazeirensis; a ...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2011.12.001
更新日期:2012-04-01 00:00:00
abstract::Since humans rarely play the role as Echinococcus oligarthrus host, there is lack of knowledge about the complex infectious process. Only three cases have been reported to occur in humans in the neotropics until now. We present the anatomo-clinical and molecular findings describing a new case of infection by E. oligar...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2012.09.004
更新日期:2013-01-01 00:00:00
abstract::The aims of this study were to describe the occurrence of dengue in space and time and to assess the relationships between dengue incidence and entomologic indicators. We selected the dengue autochthonous cases that occurred between September 2005 and August 2007 in São José do Rio Preto to calculate incidence rates b...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2014.11.017
更新日期:2015-02-01 00:00:00
abstract::A tick/rickettsial survey in various parts of Switzerland revealed the presence of a new, hitherto undescribed spotted fever group rickettsia ("Swiss agent") in up to 11.7% of I. ricinus collected off vegetation. Infection in ticks was found to be generalized with rickettsiae developing intracellularly and occasionall...
journal_title:Acta tropica
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract::Antimicrobial resistance results in selective colonization in animals. In the present study, 447 diarrheic foals (235 horse foals, 165 donkey foals and 47 mule foal) were selected from Lahore and Sahiwal districts of Punjab, Pakistan. Fresh fecal and blood samples from diarrheic foals were collected for isolation and ...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2017.08.003
更新日期:2017-12-01 00:00:00
abstract::Human alveolar and cystic echinococcosis, caused by the accidental ingestion of eggs of the tapeworms Echinococcus multilocularis and Echinococcus granulosus sensu lato, respectively, are endemic in Asia. Various Echinococcus species are maintained in domesticated and/or wild mammals through predator-prey interactions...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2017.07.013
更新日期:2017-12-01 00:00:00
abstract::Leptospirosis, a disease that occurs worldwide, especially in tropical regions, is caused by bacteria of the genus Leptospira and affects mammals, amphibians, and reptiles. Boa constrictor snakes are commonly found in Atlantic rainforest fragments in peri‑urban areas, which indicates a greater possibility of the conta...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2020.105572
更新日期:2020-09-01 00:00:00
abstract::Since 1988, the Sultanate of Oman has experienced three outbreaks of paralytic poliomyelitis. The last outbreak occurred in December 1993 and involved two children aged 10 months and 4 1/2 years. The children had received five and four doses, respectively, of trivalent oral polio vaccine (OPV) and lived in the same vi...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(01)00166-8
更新日期:2001-10-22 00:00:00
abstract::The in vitro metacyclogenesis of a visceral (VL) and cutaneous (CL) human strain of Leishmania infantum was monitored in order to find out the kinetics of this process and the in vitro infective capacity for macrophages of the metacyclic promastigotes developed. To identify, enumerate, and separate the metacyclic popu...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(98)00041-2
更新日期:1998-07-30 00:00:00
abstract::Anopheles minimus, an important malaria vector of South East Asia, has reappeared in the Singhbum hills, East-Central India where deforestation and DDT residual spraying had reportedly eliminated it during the Malaria Eradication Programme. The species reported has been identified as sibling species A of the An. minim...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2005.05.013
更新日期:2005-10-01 00:00:00
abstract::393 primary school children were screened for Schistosoma haematobium using four indirect techniques (a) history of haematuria, (b) visual appearance of urine and use of chemical reagent strips to detect presence of (c) blood and (d) protein in urine. Results showed that the use of chemical reagent strips for the dete...
journal_title:Acta tropica
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract::This study aimed to investigate the prevalence of cercarial infections in freshwater snails collected from the Chai Nat province of Central Thailand. Moreover, we aimed to develop a duplex PCR technique, using the ITS2 and candidate MT-ND1 gene, to determine the dissemination of H. taichui and H. pumilio, respectively...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2020.105795
更新日期:2020-12-10 00:00:00
abstract::Historically, the whole of Burkina Faso was considered to be endemic for onchocerciasis (except a small area in the far north of the country) with prevalence rates 60-80%, but all endemic areas were included in the World Health Organisation Onchocerciasis Control Programme, which operated a system of vector control by...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2018.05.013
更新日期:2018-09-01 00:00:00
abstract::Loop-mediated isothermal amplification (LAMP) is a novel molecular method that accelerates and facilitates DNA amplification and detection under isothermal conditions. It represents a revolution in molecular biology by reducing the high cost, turnaround time and technicality of polymerase chain reaction and other ampl...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2012.02.004
更新日期:2012-06-01 00:00:00