Abstract:
:Chandipura virus (CHPV) is an arthropod borne rhabdovirus associated with acute encephalitis in children below the age of 15 years in the tropical states of India. Although the entry of the virus into the nervous system is among the crucial events in the pathogenesis of CHPV, the exact mechanism allowing CHPV to invade the central nervous system (CNS) is currently poorly understood. In the present review, based on the knowledge of host interactors previously predicted for CHPV, along with the support from experimental data available for other encephalitic viruses, the authors have speculated the various plausible modes by which CHPV could surpass the blood-brain barrier and invade the CNS to cause encephalitis whilst evading the host immune surveillance. Collectively, this review provides a conservative set of potential interactions that can be employed for future experimental validation with a view to better understand the neuropathogenesis of CHPV.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Rajasekharan S,Rana J,Gulati S,Gupta V,Gupta Sdoi
10.1016/j.actatropica.2014.03.028subject
Has Abstractpub_date
2014-07-01 00:00:00pages
122-6eissn
0001-706Xissn
1873-6254pii
S0001-706X(14)00111-9journal_volume
135pub_type
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