Assessement of the pharmacokinetics, tissue distribution and excretion studies of a novel antiplatelet agent S007-867, following administration to rats.

abstract：:The use of performance enhancing drugs is a widespread phenomenon in professional and leisure sports. A spectroscopic study was carried out on anabolic tablets labelled as 5 mg methandienone tablets provided by police departments. The analytical approach was based on a two-step methodology: a fast analysis of tablets ...

journal_title：Drug testing and analysis

authors： Rebiere H,Ghyselinck C,Lempereur L,Brenier C

更新日期：2016-03-01 00:00:00

abstract：:Evidence of the continuous rise of novel doping agents and novel doping strategies calls for the development of more accurate multi-target screening methods. Direct multi-target screening approaches are restricted to the targeted substances and their turnover. The development of effective "indirect" screening methods ...

journal_title：Drug testing and analysis

authors： Narduzzi L,Dervilly G,Audran M,Le Bizec B,Buisson C

更新日期：2020-06-01 00:00:00

abstract：:A sensitive and selective ultra fast liquid chromatography (UFLC) method has been developed and validated for the determination of a potent and novel antitubercular compound S006-830 in Sprague Dawley (SD) rat plasma. Samples were extracted and processed by protein precipitation method using acetonitrile. Chromatograp...

journal_title：Drug testing and analysis

authors： Singh Y,Hidau MK,Misra A,Kushwaha HN,Tiwari A,Sharma AK,Singh SK

更新日期：2015-08-01 00:00:00

abstract：:Chemical warfare agents (CWA) are highly toxic compounds which have been produced to kill or hurt people during conflicts or terrorist attacks. Despite the fact that their use is strictly prohibited according to international convention, populations' exposure still recently occurred. Development of markers of exposure...

journal_title：Drug testing and analysis

authors： Spiandore M,Piram A,Lacoste A,Josse D,Doumenq P

更新日期：2014-06-01 00:00:00

abstract：:Driving under the influence of drugs (DUID) is a worldwide problem. Several countries have adopted DUID legislations which prove their deterrent effect and impact on road safety. However, the use of new psychoactive substances (NPS) and prescription drugs is not known, as the applied roadside screening tests have not ...

journal_title：Drug testing and analysis

authors： Wille SMR,Richeval C,Nachon-Phanithavong M,Gaulier JM,Di Fazio V,Humbert L,Samyn N,Allorge D

更新日期：2018-03-01 00:00:00

abstract：:Clinical and forensic toxicology laboratories are continuously confronted by analytical challenges when dealing with the new psychoactive substances phenomenon. The number of synthetic cannabinoids, the chemical diversity, and the speed of emergence make this group of compounds particularly challenging in terms of det...

journal_title：Drug testing and analysis

authors： Liu C,Jia W,Hua Z,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...

journal_title：Drug testing and analysis

authors： Abounassif MA,Al-Omar MA,Amr AG,Mostafa GA

更新日期：2011-06-01 00:00:00

abstract：:MSforID represents a database of tandem mass spectral data obtained from (quasi-)molecular ions produced by atmospheric pressure ionization methods. At the current stage of development the library contains 12 122 spectra of 1208 small (bio-)organic molecules. The present work was aimed to evaluate the performance of t...

journal_title：Drug testing and analysis

authors： Würtinger P,Oberacher H

更新日期：2012-03-01 00:00:00

abstract：:Flubromazolam is a triazole benzodiazepine with high potency and long-lasting central nervous system depressant effects; however, limited data about its pharmacokinetics are available. Here, we report in vitro studies of the human flubromazolam metabolism analyzed by liquid chromatography high-resolution mass spectrom...

journal_title：Drug testing and analysis

authors： Noble C,Mardal M,Bjerre Holm N,Stybe Johansen S,Linnet K

更新日期：2017-08-01 00:00:00

abstract：:Anabolic-androgenic steroids are synthetic compounds prohibited due to their performance-enhancing characteristics. The use of these substances is known to cause health-related issues, which highlights the importance of being able to evaluate the scale of consumption by the general population. However, most available ...

journal_title：Drug testing and analysis

authors： Shimko KM,O'Brien JW,Barron L,Kayalar H,Mueller JF,Tscharke BJ,Choi PM,Jiang H,Eaglesham G,Thomas KV

更新日期：2019-07-01 00:00:00

abstract：:Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N-ethylnorpentylone (also known as N-ethylpentylone or ephylone) is a popular emergent cathinone, yet little information is available about its toxicology and pharmacology. Here we characterize the analytical quantification, clinical p...

journal_title：Drug testing and analysis

authors： Costa JL,Cunha KF,Lanaro R,Cunha RL,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：:Autologous blood transfusion is a powerful means of improving performance and remains one of the most challenging methods to detect. Recent investigations have identified 3 candidate reticulocytes genes whose expression was significantly influenced by blood transfusion. Using quantitative reverse transcription polymer...

journal_title：Drug testing and analysis

authors： Salamin O,Mignot J,Kuuranne T,Saugy M,Leuenberger N

更新日期：2018-03-01 00:00:00

abstract：:Cobalt is an essential mineral micronutrient and is regularly present in equine nutritional and feed supplements. Therefore, cobalt is naturally present at low concentrations in biological samples. The administration of cobalt chloride is considered to be blood doping and is thus prohibited. To control the misuse of c...

journal_title：Drug testing and analysis

authors： Popot MA,Ho ENM,Stojiljkovic N,Bagilet F,Remy P,Maciejewski P,Loup B,Chan GHM,Hargrave S,Arthur RM,Russo C,White J,Hincks P,Pearce C,Ganio G,Zahra P,Batty D,Jarrett M,Brooks L,Prescott LA,Bailly-Chouriberry L,Bo

更新日期：2017-09-01 00:00:00

abstract：:Erythropoietin (EPO) has been misused in sports for many years due to its performance-enhancing effect. In the last decade, detection of abuse has been possible with isoelectric focusing (IEF) based on the different isoform profiles of endogenous and recombinant EPO. The release of new EPOs on the market, such as the ...

journal_title：Drug testing and analysis

authors： Dehnes Y,Hemmersbach P

更新日期：2011-05-01 00:00:00

abstract：:1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P-LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous sel...

journal_title：Drug testing and analysis

authors： Grumann C,Henkel K,Brandt SD,Stratford A,Passie T,Auwärter V

更新日期：2020-08-01 00:00:00

abstract：:A quantitative structure-property relationship (QSPR) study based on an artificial neural network (ANN) was carried out for the prediction of the microemulsion liquid chromatography polar surface area (PSA) of a set of 32 drug compounds. The genetic algorithm-kernel partial least squares (GA-KPLS) method was used as a...

journal_title：Drug testing and analysis

authors： Noorizadeh H,Farmany A,Noorizadeh M,Kohzadi M

更新日期：2013-04-01 00:00:00

abstract：:The synthetic tryptamine 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) has recently been abused as a hallucinogenic drug in Germany and Switzerland. This study presents a case of 5-MeO-MiPT intoxication and the structural elucidation of metabolites in pooled human liver microsomes (pHLM), blood, and urine. Mic...

journal_title：Drug testing and analysis

authors： Grafinger KE,Hädener M,König S,Weinmann W

更新日期：2018-03-01 00:00:00

abstract：:A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT-modified GCE exhibite...

journal_title：Drug testing and analysis

authors： Xi X,Ming L,Liu J

更新日期：2011-03-01 00:00:00

abstract：:In the field of natural extracts, research generally focuses on the study of their biological activities for food, cosmetic, or pharmacological purposes. The evaluation of their adverse effects is often overlooked. In this study, the extracts of Thymus vulgaris L. were obtained by two different extraction methods. Int...

journal_title：Drug testing and analysis

authors： Benourad F,Kahvecioglu Z,Youcef-Benkada M,Colet JM

更新日期：2014-10-01 00:00:00

abstract：:Selective androgen receptor modulators (SARMs) have great therapeutic potential in various diseases including cancer cachexia, sarcopenia, and osteoporosis, and the number of drug candidates has been growing over the last decade. The SARM drug candidates S-22 and S-23 belong to one of the most advanced groups of andro...

journal_title：Drug testing and analysis

authors： Thevis M,Gerace E,Thomas A,Beuck S,Geyer H,Schlörer N,Kearbey JD,Dalton JT,Schänzer W

更新日期：2010-11-01 00:00:00

abstract：:Phosphatidylethanol 16:0/18:1 (PEth) is the most abundant homologue of the phosphatidylethanol group of phospholipids. Formed only in the presence of ethanol, PEth is used as a biomarker in whole blood to provide information about the consumption of alcohol. As information on the storage life of PEth is essential for ...

journal_title：Drug testing and analysis

authors： Dumitrascu C,van de Lavoir MCA,Neels H,Covaci A,Jacobs W,D'Hondt D,van Nuijs ALN

更新日期：2021-01-04 00:00:00

abstract：:Current doping trends overshadow the traditional interpretation of using prohibited performance-enhancing drugs to improve training and/or sports results. Its definition has evolved due to several recent cases of unconventional manipulation in sports. In this article, we present a case study of an intentional intoxica...

journal_title：Drug testing and analysis

authors： Baltazar-Martins G,Del Mar Plata M,Muñoz-Guerra J,Argaya J,Del Coso J

更新日期：2020-05-01 00:00:00

abstract：:To date, substances such as Mildronate (Meldonium) are not on the radar of anti-doping laboratories as the compound is not explicitly classified as prohibited. However, the anti-ischemic drug Mildronate demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection ag...

journal_title：Drug testing and analysis

authors： Görgens C,Guddat S,Dib J,Geyer H,Schänzer W,Thevis M

更新日期：2015-11-01 00:00:00

abstract：:Deschloroketamine (2-(methylamino)-2-phenyl-cyclohexanone) is a ketamine analog belonging to a group of dissociative anesthetics, which have been distributed within the illicit market since 2015. However, it was also being sold as 'ketamine' misleading people to believe that they were getting genuine ketamine. Dissoci...

journal_title：Drug testing and analysis

authors： Hájková K,Jurásek B,Čejka J,Štefková K,Páleníček T,Sýkora D,Kuchař M

更新日期：2020-03-01 00:00:00

abstract：:Sulfate metabolites have been described as long-term metabolites for some anabolic androgenic steroids (AAS). 4-chlorometandienone (4Cl-MTD) is one of the most frequently detected AAS in sports drug testing and it is commonly detected by monitoring metabolites excreted free or conjugated with glucuronic acid. Sulfatio...

journal_title：Drug testing and analysis

authors： Balcells G,Gómez C,Garrostas L,Pozo ÓJ,Ventura R

更新日期：2017-07-01 00:00:00

abstract：:The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detection and identification of these compounds, further analytical challenges may arise from the presence of possible metab...

journal_title：Drug testing and analysis

authors： Soh YN,Elliott S

更新日期：2014-07-01 00:00:00

abstract：:Anabolic-androgenic steroids (AAS) represent one of the most frequently detected classes of prohibited substances in doping controls. Due to their long-lasting beneficial effects on athletic performance, utmost retrospectivity via urine analysis is desirable and accomplished by targeting long-term metabolites of the r...

journal_title：Drug testing and analysis

authors： Schänzer W,Guddat S,Thomas A,Opfermann G,Geyer H,Thevis M

更新日期：2013-11-01 00:00:00

abstract：:An orthogonal signal correction-partial least squares (OSC-PLS) method was developed for the simultaneous spectrophotometric determination of orotic acid (OA), creatinine (CRE), and uric acid (UA) in spiked real samples. By multivariate calibration methods, such as PLS regression, it is possible to obtain a model adju...

journal_title：Drug testing and analysis

authors： Khajehsharifi H,Tavallali H,Shekoohi M,Sadeghi M

更新日期：2013-05-01 00:00:00

abstract：:Designer drugs belong to a group of legally or illegally produced substances that are structurally and pharmacologically very similar to illicit drugs. In the past, designer drugs were often used during all-night dance parties, but they are now consumed in multiple settings from college bars to parks to private house ...

journal_title：Drug testing and analysis

authors： Karila L,Reynaud M

更新日期：2011-09-01 00:00:00

abstract：:Docetaxel (DTX) is an anti-cancer compound derived from 10-deacetyl baccatin III which is indicated for treatment of breast, lung, prostate, gastro-esophageal, and head and neck cancers. Epimerization of DTX at the C-7 hydroxyl position has intrigued chemists and has been implicated in loss of potency, as well as in t...

journal_title：Drug testing and analysis

authors： Mohsin S,Arellano IH,Choudhury NR,Garg S

更新日期：2014-10-01 00:00:00