Comparison of sedation with temazepam by mouth and diazemuls i.v. for dental surgery. Variability in absorption may influence clinical effect.

abstract：BACKGROUND:Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing for...

journal_title：British journal of anaesthesia

authors： Zuppa AF,Nicolson SC,Wilder NS,Ibla JC,Gottlieb EA,Burns KM,Stylianou M,Trachtenberg F,Ni H,Skeen TH,Andropoulos DB,Pediatric Heart Network Investigators.

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The analgesia/nociception index (ANI), a 0-100 non-invasive index calculated from heart rate variability, reflects the analgesia/nociception balance during general anaesthesia. The aim of this study was to evaluate the ANI in the assessment of immediate postoperative pain in adult patients undergoing general...

journal_title：British journal of anaesthesia

authors： Boselli E,Daniela-Ionescu M,Bégou G,Bouvet L,Dabouz R,Magnin C,Allaouchiche B

更新日期：2013-09-01 00:00:00

abstract：:An histaminoid reaction after the administration of thiopentone and atracurium is described. Serial blood sampling showed no evidence of complement activation. Intradermal testing 6 weeks later yielded a positive result with atracurium (1 in 1000), but not with thiopentone. The clinical course of the reaction and the ...

journal_title：British journal of anaesthesia

authors： Lavery GG,Boyle MM,Mirakhur RK

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:The debate on lung-protective ventilation strategies for surgical patients is ongoing. Evidence suggests that the use of low tidal volume VT improves clinical outcomes. However, the optimal levels of PEEP and recruitment manoeuvre (RM) strategies incorporated into low VT ventilation remain unclear. METHODS:...

journal_title：British journal of anaesthesia

authors： Deng QW,Tan WC,Zhao BC,Wen SH,Shen JT,Xu M

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models. METHODS:Wistar rats were submitted to the formalin test and to partial ligation of the sciatic nerve (Seltzer's model). Swiss Webster mice w...

journal_title：British journal of anaesthesia

authors： Marcil J,Walczak JS,Guindon J,Ngoc AH,Lu S,Beaulieu P

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Circadian rhythms coordinate almost all physiological functions and are implicated in major disease development. Even though circadian rhythms have a major impact on human health, little is known about how they affect general anaesthesia. The purpose of this study was to understand if the time of day affects...

journal_title：British journal of anaesthesia

authors： Szolnoki J,Polaner DM,Eckle T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Left ventricular (LV) pressure-volume (PV) loops were used to compare the functional effects that accompany the cardioprotection seen with desflurane, sevoflurane, and propofol in a rabbit preparation of coronary ischaemia-reperfusion (IR). METHODS:Male New Zealand White rabbits (n=48) were anaesthetized wi...

journal_title：British journal of anaesthesia

authors： Andrews DT,Royse AG,Royse CF

更新日期：2009-11-01 00:00:00

abstract：:Blood samples were obtained from a radial artery cannula in a 60-yr-old man during coronary artery surgery. Serum potassium concentrations of 9.3, 8.4, and 7.4 mmol litre(-1) were obtained. A simultaneous venous blood sample gave a serum potassium concentration of 4.4 mmol litre(-1). The ECG was unchanged. After the a...

journal_title：British journal of anaesthesia

authors： Mehta V,Ahmed Z

更新日期：2004-09-01 00:00:00

abstract：:We have studied the haemodynamic and myocardial effects of propofol-fentanyl anaesthesia in 12 patients undergoing coronary artery bypass surgery during the pre-bypass period. The induction dose of propofol was 1.5 mg kg-1 and mean infusion rate during maintenance was 4.48 mg kg-1 h-1 (range 1.87-7.24 mg kg-1 h-1). Th...

journal_title：British journal of anaesthesia

authors： Vermeyen KM,De Hert SG,Erpels FA,Adriaensen HF

更新日期：1991-04-01 00:00:00

abstract：:We have compared the effects of sevoflurane and halothane on the discharge frequencies of 19 slowly adapting and four rapidly adapting lung receptors in the rabbit by recording from single vagal fibres. Both agents reduced the discharge frequency of slowly adapting receptors during expiration (P < 0.0005), halothane h...

journal_title：British journal of anaesthesia

authors： Moores C,Davies AS,Dallak M

更新日期：1998-02-01 00:00:00

abstract：:It is generally accepted that halothane reduces airway and tissue resistance in lungs with preexisting airway tone. However, under conditions of resting airway tone, pulmonary resistance remains unaltered. In this study, we have determined the effects of halothane on respiratory system, pulmonary and chest wall resist...

journal_title：British journal of anaesthesia

authors： Reta GS,Riva JA,Piriz H,Medeiros AS,Rocco PR,Zin WA

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Tracheal tube tip and cuff positions of different cuffed paediatric tracheal tube brands in the trachea can vary with design. METHODS:Data from three clinical studies with measured tracheal lengths were pooled in a database including 422 children aged from birth to 16 yr. Dimensional data of seven cuffed pa...

journal_title：British journal of anaesthesia

authors： Kemper M,Imach S,Buehler PK,Thomas J,Dave M,Weiss M

更新日期：2018-08-01 00:00:00

abstract：:We have conducted a randomized, double-blind comparison of 4% and 8% sevoflurane for induction of anaesthesia in unpremedicated patients aged more than 60 yr. Sevoflurane was inhaled in 50% nitrous oxide using a vital capacity breath technique, and mean, systolic and diastolic arterial pressures and heart rate were mo...

journal_title：British journal of anaesthesia

authors： Walpole R,Logan M

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Perioperative warming is recommended for surgery under anaesthesia, however its role during Caesarean delivery remains unclear. This meta-analysis aimed to determine the efficacy of active warming on outcomes after elective Caesarean delivery. METHODS:We searched databases for randomized controlled trials u...

journal_title：British journal of anaesthesia

authors： Sultan P,Habib AS,Cho Y,Carvalho B

更新日期：2015-10-01 00:00:00

abstract：:The effects of physostigmine 1 mg i.v. were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10 mg/60 kg i.v. in 10 patients recovering from surgery. Within 5-10 min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values. A...

journal_title：British journal of anaesthesia

authors： Weinstock M,Davidson JT,Rosin AJ,Schnieden H

更新日期：1982-04-01 00:00:00

abstract：:A disposable patient-controlled analgesia (PCA) device was evaluated in 20 children after major abdominal, urological and orthopaedic surgery. All patients were given a high dependency level of nursing care in general wards. Efficacy (as assessed by hourly pain scores) was comparable to that achieved in a matched cont...

journal_title：British journal of anaesthesia

authors： Irwin M,Gillespie JA,Morton NS

更新日期：1992-04-01 00:00:00

abstract：:This review describes the laboratory evidence and microvascular mechanisms responsible for the beneficial effects of statins in sepsis. During sepsis, changes occur within the microcirculation including alterations in arteriolar tone influencing blood pressure, adaptations to endothelial cell integrity causing leakage...

journal_title：British journal of anaesthesia

authors： McGown CC,Brookes ZL

更新日期：2007-02-01 00:00:00

abstract：:Gastric pH and volume were measured in 87 patients who had received i.v. omeprazole (a new gastric antisecretory agent) 40 mg or placebo 1 or 3 h before surgery. Omeprazole increased the pH of gastric contents in the majority of patients. Administration 1 h before surgery produced greater gastric pH and smaller volume...

journal_title：British journal of anaesthesia

authors： Cruickshank RH,Morrison DA,Bamber PA,Nimmo WS

更新日期：1989-11-01 00:00:00

abstract：:We have studied the efficacy of i.v. clonidine to suppress post-extradural shivering in parturients. Forty healthy parturients who received extradural block for labour (n = 20) or for Caesarean section (n = 20) and who required treatment for shivering after delivery were allocated randomly to two groups. Group I recei...

journal_title：British journal of anaesthesia

authors： Capogna G,Celleno D

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Emotional information has the ability to alter the formation and strength of a memory ('memory modulation'). Memory modulation by negative emotion is mediated by the amygdala. It is not known how gamma aminobutyric acid (GABA)ergic drugs affect the processes involved in memory modulation. This study investig...

journal_title：British journal of anaesthesia

authors： Pryor KO,Veselis RA,Reinsel RA,Feshchenko VA

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:In this randomized, double-blind study, the effects of thoracic and lumbar epidural anaesthesia on the induction doses (IDs) and maintenance doses (MDs) of propofol during bispectral index (BIS) guided total i.v. anaesthesia were compared. METHODS:Fifty-four patients (three groups, n=18 each) undergoing uro...

journal_title：British journal of anaesthesia

authors： Sentürk M,Güçyetmez B,Ozkan-Seyhan T,Karadeniz M,Dinçer S,Akpir D,Sengül T,Denkel T

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:One-lung ventilation (OLV) increases mechanical stress in the lung and affects ventilation and perfusion (V, Q). There are no data on the effects of OLV on postoperative V/Q matching. Thus, this controlled study evaluates the influence of OLV on V/Q distribution in a pig model using a gamma camera technique ...

journal_title：British journal of anaesthesia

authors： Kozian A,Schilling T,Fredén F,Maripuu E,Röcken C,Strang C,Hachenberg T,Hedenstierna G

更新日期：2008-04-01 00:00:00

abstract：:Metoclopramide hastens emptying of the stomach. Since it may be given to patients before operation, the sedative and toxic effects of 10- and 20-mg does given i.m. were studied in patients and student volunteers. Saline and diazepam 10 mg were used as placebo and reference drugs. Neither dose of metoclopramide had as ...

journal_title：British journal of anaesthesia

authors： Dundee JW,Clarke RS,Howard PJ

更新日期：1974-07-01 00:00:00

abstract：:Haemodynamic effects may occur after stellate ganglion block (SGB) arising from autonomic imbalance and local anaesthetic infiltration to barosensitive areas. We report seven patients who developed severe hypertension (systolic arterial pressure >200 mm Hg) after SGB in our pain clinic service. We postulate that diffu...

journal_title：British journal of anaesthesia

authors： Kimura T,Nishiwaki K,Yokota S,Komatsu T,Shimada Y

更新日期：2005-06-01 00:00:00

abstract：:The speeds of onset of pancuronium, atracurium and vecuronium are increased by prior administration of magnesium sulphate. A prospective, randomized, double-blind, controlled, clinical study was performed to examine the effects of prior i.v. administration of magnesium sulphate 60 mg kg-1 on the neuromuscular blocking...

journal_title：British journal of anaesthesia

authors： Kussman B,Shorten G,Uppington J,Comunale ME

更新日期：1997-07-01 00:00:00

abstract：:We have investigated 296 inpatients in a single-blind observer study to determine the incidence, degree and duration of hypoxaemia during anaesthesia. The clinical recognition of hypoxaemia, period of time until recognition and risk factors were studied. Oxygen saturation (Spo2) was monitored continuously with a pulse...

journal_title：British journal of anaesthesia

authors： Moller JT,Johannessen NW,Berg H,Espersen K,Larsen LE

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Microvascular dysfunction is considered to play an important pathophysiological role in sepsis. We addressed the hypothesis that macrovascular and microvascular flow are uncoupled in early sepsis, using a rodent model with well-characterized haemodynamic and biochemical markers of severity and subsequent mor...

journal_title：British journal of anaesthesia

authors： Dyson A,Cone S,Singer M,Ackland GL

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:The safe performance of regional anaesthesia (RA) requires theoretical knowledge and good manual skills. Virtual reality (VR)-based simulators may offer trainees a safe environment to learn and practice different techniques. However, currently available VR simulators do not consider individual anatomy, which...

journal_title：British journal of anaesthesia

authors： Grottke O,Ntouba A,Ullrich S,Liao W,Fried E,Prescher A,Deserno TM,Kuhlen T,Rossaint R

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The objective of this study was to test whether non-invasive assessment of respiratory stroke volume variation (ΔrespSV) by oesophageal Doppler monitoring (ODM) can predict fluid responsiveness during surgery in a mixed population. The predictive value of ΔrespSV was evaluated using a grey zone approach. ME...

journal_title：British journal of anaesthesia

authors： Guinot PG,de Broca B,Abou Arab O,Diouf M,Badoux L,Bernard E,Lorne E,Dupont H

更新日期：2013-01-01 00:00:00

abstract：:One hundred and one patients with osteoarthritis were randomly allocated to undergo total hip arthroplasty under either spinal (subarachnoid) or general anaesthesia. Venous blood was sampled before, during and after surgery and on the 5th day after operation to study the haemostatic mechanism. There were no preoperati...

journal_title：British journal of anaesthesia

authors： Davis FM,McDermott E,Hickton C,Wells E,Heaton DC,Laurenson VG,Gillespie WJ,Foate J

更新日期：1987-05-01 00:00:00