Effects of halothane on respiratory mechanics and lung histopathology in normal rats.

abstract：:We have studied the effects of alcuronium in 10 healthy, non-anaesthetized volunteers after they had been taking oral pyridostigmine 30 mg 8 hourly. The responses of adductor pollicis were recorded using an isolated forearm procedure (IFP) during onset and recovery of neuromuscular block produced by 1.5 mg of relaxant...

journal_title：British journal of anaesthesia

authors： Turner GA,Williams JD,Baker DJ

更新日期：1991-03-01 00:00:00

abstract：:Blood flow to functionally different vascular beds was examined during a sodium nitroprusside infusion in 10 dogs anaesthetized with halothane (1 MAC) in oxygen. Blood flows were measured in the ascending aorta, and the coeliac, superior mesenteric, renal and iliac arteries. In two dogs, regional vascular impedance an...

journal_title：British journal of anaesthesia

authors： Bagshaw RJ,Cox RH,Campbell KB

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:Medication-related adverse events (MRE) in anaesthesia care are frequent and require a deeper understanding if we are to prevent medication harm. METHODS:We searched for reported MRE from the Spanish Anaesthesia Incident Reporting System (SENSAR) database over a 10-yr period. SENSAR is a cross-national, mul...

journal_title：British journal of anaesthesia

authors： Sanduende-Otero Y,Villalón-Coca J,Romero-García E,Díaz-Cambronero Ó,Barach P,Arnal-Velasco D

更新日期：2020-02-01 00:00:00

abstract：:The rate of liquid-phase gastric emptying was determined in seven smokers from the rate of paracetamol absorption after abstaining overnight from cigarettes, and again after smoking two cigarettes within 30 min. There were no significant differences between the maximum paracetamol concentration, the time to reach maxi...

journal_title：British journal of anaesthesia

authors： Petring OU,Adelhøj B,Ibsen M,Brynnum J,Poulsen HE

更新日期：1985-11-01 00:00:00

abstract：:Although well established in clinical practice, both propofol and midazolam have limitations. New hypnotics with different and potentially superior pharmacokinetics and pharmacodynamics are under development. These include the benzodiazepine receptor agonists CNS7056 and JM-1232 (-), the etomidate-based methoxycarbony...

journal_title：British journal of anaesthesia

authors： Sneyd JR,Rigby-Jones AE

更新日期：2010-09-01 00:00:00

abstract：:Thirty hypertensive patients scheduled for cholecystectomy or hernia repair under general anaesthesia with thiopentone-fentanyl-nitrous oxide-pancuronium were divided into two groups of 15. One group received metoprolol tablets 200 mg in a slow release form, once daily for at least 2 weeks including the morning of sur...

journal_title：British journal of anaesthesia

authors： Magnusson J,Thulin T,Werner O,Järhult J,Thomson D

更新日期：1986-03-01 00:00:00

abstract：:Amethocaine 1% solution was mixed with equal volumes of water, 0.9% saline or 10% dextrose to prepare respectively, hypobaric, isobaric and hyperbaric solutions which were compared for intradural spinal anaesthesia in 60 patients. Thirty patients received 10 mg and 30 patients received 15 mg of amethocaine. Injections...

journal_title：British journal of anaesthesia

authors： Brown DT,Wildsmith JA,Covino BG,Scott DB

更新日期：1980-06-01 00:00:00

abstract：:Plasma concentrations of amethocaine were measured after topical application of amethocaine cream 2 g (5% w/w) to the dorsum of the right hand of 10 adult volunteers. The cream was applied for 240 min and plasma was assayed for amethocaine and its metabolite p-n-butylaminobenzoic acid at 0, 30, 60, 90, 120 and 240 min...

journal_title：British journal of anaesthesia

authors： Mazumdar B,Tomlinson AA,Faulder GC

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Ivabradine lowers heart rate (HR) without affecting contractility or vascular tone. It is licensed for HR control in chronic heart diseases. We performed a systematic review and meta-analyses to examine whether ivabradine could decrease major adverse cardiovascular events (MACE) and mortality in critically i...

journal_title：British journal of anaesthesia

authors： Chen A,Elia N,Dunaiceva J,Rudiger A,Walder B,Bollen Pinto B

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients after major surgery. An association between POCD and the development of dementia has been suspected. In this study, we assessed if POCD was a risk factor for the occurrence of dementia. METHODS:Danish patients enrolled b...

journal_title：British journal of anaesthesia

authors： Steinmetz J,Siersma V,Kessing LV,Rasmussen LS,ISPOCD Group.

更新日期：2013-06-01 00:00:00

abstract：:The 119 patients who had undergone previous Caesarean section lumbar extradural block was administered to 77 (65%); the other 42 (35%) received analgesia with ketobemidone 0.8-1.0 ml i.m. or nitrous oxide in oxygen intermittently, or both. Controlled i.v. infusion of oxytocin for induction or acceleration of labour wa...

journal_title：British journal of anaesthesia

authors： Carlsson C,Nybell-Lindahl G,Ingemarsson I

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:The Laryngeal Tube (LT) performs similarly to the classic laryngeal mask airway during controlled ventilation but with an improved airway seal. We compared the laryngeal tube with the ProSeal laryngeal mask airway (PLMA) throughout anaesthesia. METHODS:Thirty-two patients were studied using a randomized cro...

journal_title：British journal of anaesthesia

authors： Cook TM,McKinstry C,Hardy R,Twigg S

更新日期：2003-11-01 00:00:00

abstract：:In a prospective randomized multi-centre study, the mortality following internal fixation surgery for fracture of the upper femur was investigated in 538 elderly patients allocated to receive subarachnoid blockade or general (narcotic-relaxant) anaesthesia. The 28-day mortality was 6.6% with subarachnoid, and 5.9% wit...

journal_title：British journal of anaesthesia

authors： Davis FM,Woolner DF,Frampton C,Wilkinson A,Grant A,Harrison RT,Roberts MT,Thadaka R

更新日期：1987-09-01 00:00:00

abstract：:General anaesthesia for emergency surgery in a pressurized habitat is likely to involve the use of i.v. agents. The anaesthetic property of such agents is known to be antagonized by pressure, but the effect on their duration of action is not easily predicted. The recovery of mice from a single i.v. dose of Althesin, k...

journal_title：British journal of anaesthesia

authors： Shearer AJ,Ross JA,Manson HJ

更新日期：1981-05-01 00:00:00

abstract：:We have investigated the effect of a bolus injection of atracurium 0.6 mg kg-1 on the cardiovascular system in 16 patients undergoing aortocoronary bypass surgery. H1- and H2-receptor antagonists were administered to eight patients before the neuromuscular blocker. A standard anaesthetic was used comprising fentanyl, ...

journal_title：British journal of anaesthesia

authors： Adt M,Baumert JH,Reimann HJ

更新日期：1992-02-01 00:00:00

abstract：:Local reactions after i.v. injection of diazepam, flunitrazepam and isotonic saline were studied in patients who received extradural analgesia or general anaesthesia. The frequency of thrombophlebitis on the 1st, 3rd and 5th days after the injection of diazepam was 2.1%, 17.0% and 14.9% respectively, after flunitrazep...

journal_title：British journal of anaesthesia

authors： Mikkelsen H,Hoel TM,Bryne H,Krohn CD

更新日期：1980-08-01 00:00:00

abstract：:One hundred patients presenting for surgical treatment of fractured neck of femur were allocated to receive either spinal (SAB) or general (GA) anaesthesia. Before operation, the mean PaO2 was 9.04 kPa. There was a significant decrease in PaO2 of 0.68 kPa in GA group at 1 h after operation, while blood-gas values were...

journal_title：British journal of anaesthesia

authors： McKenzie PJ,Wishart HY,Dewar KM,Gray I,Smith G

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:In a series of ex vivo and in vivo studies we investigated the ability of repetitive ketamine administration to alter the metabolism and anaesthetic effect of propofol and the role of ketamine-mediated P-450 2B induction in rats. METHODS:Male Wistar rats were pretreated with 80 mg kg(-1) ketamine i.p. twice...

journal_title：British journal of anaesthesia

authors： Chan WH,Chen TL,Chen RM,Sun WZ,Ueng TH

更新日期：2006-09-01 00:00:00

abstract：:Cytokine synthesis and release is an essential component of the innate immune system, but inappropriate, excessive production results in a generalized systemic inflammatory response which damages distant organs. Recent research has identified an immunomodulatory function of the vagus nerve whereby activation of the ef...

journal_title：British journal of anaesthesia

authors： Johnston GR,Webster NR

更新日期：2009-04-01 00:00:00

abstract：:The time course of the plasma lignocaine concentration, following caudal anaesthesia, was studied in 11 healthy children (3.5-9 yr). Plasma lignocaine concentrations were measured for up to 6 h after administration (5 mg kg-1). Peak plasma concentration was 2.05 +/- 0.08 micrograms ml-1 and occurred at 28.2 +/- 2.9 mi...

journal_title：British journal of anaesthesia

authors： Ecoffey C,Desparmet J,Berdeaux A,Maury M,Giudicelli JF,Saint-Maurice C

更新日期：1984-12-01 00:00:00

abstract：:The effect of incubation at 37 degrees C, 46 degrees C, 47 degrees C and 48 degrees C for 1 h on the osmotic fragility of blood was determined. Blood taken from volunteers into ACD and CPD was examined after 1, 7, 14 and 21 days of storage. In addition, 22-day-old blood stored in CPD was examined. The osmotic fragilit...

journal_title：British journal of anaesthesia

authors： Van der Walt JH,Russell WJ

更新日期：1978-08-01 00:00:00

abstract：:A combination of exogenous surfactant and partial liquid ventilation (PLV) with perfluorocarbons should enhance gas exchange, improve respiratory mechanics and reduce tissue damage of the lung in acute lung injury (ALI). We used a small dose of exogenous surfactant with and without PLV in an experimental model of ALI ...

journal_title：British journal of anaesthesia

authors： Wolf S,Lohbrunner H,Busch T,Sterner-Kock A,Deja M,Sarrafzadeh A,Neumann U,Kaisers U

更新日期：2001-10-01 00:00:00

abstract：:The effect of the administration of propranolol 0.15 mg per kg body weight i.v. on the metabolic response to pelvic surgery was compared with results in similar patients who had not received propranolol. The only significant difference between the two groups was a lower plasma insulin concentration in the beta-blockad...

journal_title：British journal of anaesthesia

authors： Cooper GM,Paterson JL,Mashiter K,Hall GM

更新日期：1980-12-01 00:00:00

abstract：:The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1...

journal_title：British journal of anaesthesia

authors： Aun CS,Short SM,Leung DH,Oh TE

更新日期：1992-01-01 00:00:00

abstract：:Regional haemodynamic control by the cardiovascular baroreceptors was examined in dogs anaesthetized with 1 + MAC halothane in oxygen (1%). The open-loop relationships between carotid sinus pressure (CSP) and regional haemodynamics in the iliac, renal, mesenteric, aortic and coeliac beds were examined before vagotomy,...

journal_title：British journal of anaesthesia

authors： Bagshaw RJ,Cox RH

更新日期：1977-06-01 00:00:00

abstract：:The haemodynamic effects of diltiazem were studied in six dogs during fentanyl-nitrous oxide (in oxygen) anaesthesia. A bolus of diltiazem 300 micrograms kg-1 was given, followed by infusions at 30, 60 and 90 micrograms kg-1 min-1 which produced plasma diltiazem concentrations of 392 +/- 30, 908 +/- 54 and 1483 +/- 13...

journal_title：British journal of anaesthesia

authors： Griffin RM,Dimich I,Jurado R,Kaplan JA

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Atelectasis is known to develop during anaesthesia and after operation atelectasis leads to impaired oxygenation. Lung recruitment manoeuvres, positive end-expiratory pressure (PEEP), and continuous positive airway pressure (CPAP) have been proposed for reduction of atelectasis but their benefits have not be...

journal_title：British journal of anaesthesia

authors： Lumb AB,Greenhill SJ,Simpson MP,Stewart J

更新日期：2010-05-01 00:00:00

abstract：:The effects of the i.v. infusion of insulin, 70 mu. kg-1h-1 for the first 60 min and 35 mu. kg-1h-1 subsequently, on the metabolic and endocrine responses to gynaecological surgery were investigated. In comparison with a control group of patients, the insulin infusion caused a marked decrease in circulating glucose, n...

journal_title：British journal of anaesthesia

authors： Hall GM,Walsh ES,Paterson JL,Mashiter K

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:As general anaesthesia may compromise the immune system, it has been hypothesized that latent varicella-zoster virus is more likely to be reactivated and cause herpes zoster in mothers after Caesarean deliveries under general anaesthesia. Our study was thus aimed at investigating the risk of herpes zoster am...

journal_title：British journal of anaesthesia

authors： Chen YH,Rau RH,Keller JJ,Lin HC

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The population in the UK is growing older and the number of elderly patients cared for on intensive care units (ICU) is increasing. This study was designed to identify risk factors for mortality in critically ill patients of >80 yr of age after surgery. METHODS:We identified 275 patients, aged 80 yr or grea...

journal_title：British journal of anaesthesia

authors： Ford PN,Thomas I,Cook TM,Whitley E,Peden CJ

更新日期：2007-12-01 00:00:00