Cytokines and the immunomodulatory function of the vagus nerve.

Abstract:

:Cytokine synthesis and release is an essential component of the innate immune system, but inappropriate, excessive production results in a generalized systemic inflammatory response which damages distant organs. Recent research has identified an immunomodulatory function of the vagus nerve whereby activation of the efferent arm results in regulation of cytokine production. Termed the 'cholinergic anti-inflammatory pathway', this neuro-immune communication provides the host with a fast, discrete, and localized means of controlling the immune response and preventing excessive inflammation. Stimulation of the vagus nerve attenuates cytokine production and improves survival in experimental sepsis, haemorrhagic shock, ischaemia-reperfusion injury, and other conditions of cytokine excess and research is now underway in developing new and novel therapeutics aimed at stimulating the vagus nerve either directly or targeting specific components of the pathway.

journal_name

Br J Anaesth

authors

Johnston GR,Webster NR

doi

10.1093/bja/aep037

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

453-62

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)34466-5

journal_volume

102

pub_type

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