Dobutamine increases oxygen consumption during constant flow cardiopulmonary bypass.

Abstract:

:We have studied the effects of flow and dobutamine on systemic haemodynamic variables, oxygen delivery (DO2) and oxygen consumption (VO2) in 20 patients during cardiopulmonary bypass (CPB) with mild hypothermia (34 degrees C). In a subgroup of seven patients, we also studied the effects on gastric microcirculatory blood flow (MCF) using laser Doppler flowmetry. During CPB, measurements were made before and after two interventions: the first consisted of increasing flow from 2.4 to 3.0 litre min-1 m-2 for 10 min; the second consisted of an infusion of dobutamine at a rate of 6 micrograms kg-1 min-1 for 10 min during constant flow CPB. There were no significant differences in DO2, VO2 or haemodynamic variables between the two baseline measurements. The increase in flow raised DO2 (27%, P < 0.001), mean arterial pressure (P < 0.01) and MCF (P < 0.01), but failed to increase VO2. In contrast, dobutamine infusion increased VO2 (11%, P < 0.001) during constant flow CPB without significant changes in DO2, systemic haemodynamic variables or MCF. These results indicate that increases in VO2 during dobutamine may be flow-independent.

journal_name

Br J Anaesth

authors

Karzai W,Lötte A,Günnicker M,Vorgrimler-Karzai UM,Priebe HJ

doi

10.1093/bja/76.1.5

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

5-8

issue

1

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)43930-4

journal_volume

76

pub_type

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