Effect of physostigmine on morphine-induced postoperative pain and somnolence.

Abstract:

:The effects of physostigmine 1 mg i.v. were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10 mg/60 kg i.v. in 10 patients recovering from surgery. Within 5-10 min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values. Analgesia, assessed by an independent observer and by the patient was, if anything, increased by physostigmine. The analeptic effect of physostigmine lasted 40-60 min.

journal_name

Br J Anaesth

authors

Weinstock M,Davidson JT,Rosin AJ,Schnieden H

doi

10.1093/bja/54.4.429

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

429-34

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)42771-1

journal_volume

54

pub_type

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