Abstract:
:Embryo implantation requires a reciprocal interaction between the blastocyst and endometrium and is associated with complex regulatory mechanisms. Since their discovery, microRNAs became prominent candidates providing missing links for many biological pathways. In recent years, microRNAs were implicated as one of the important players in regulation of various biological and physiological endometrial related processes. This chapter aims to present recent knowledge pertaining to the diverse aspects of microRNAs in the embryo-endometrial relationship. We will focus on the role of microRNAs in decidualization and their part in natural and stimulated cycles. Next, we will present recent studies deliberating the role of microRNAs in recurrent pregnancy loss and in the important phenomenon of recurrent implantation failure. Lastly, demonstrating an important aspect of embryo implantation and invasion, we will outline few microRNA related shared pathways of implantation and carcinogenesis.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Chill HH,Dior UP,Kogan L,Revel Adoi
10.1007/978-3-319-22380-3_8subject
Has Abstractpub_date
2015-01-01 00:00:00pages
143-55eissn
0065-2598issn
2214-8019journal_volume
887pub_type
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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