Abstract:
:Aldehyde dehydrogenases are a family of enzymes that oxidize aldehydes to carboxylic acids. These enzymes are important in cellular homeostasis during oxidative stress by the elimination of toxic aldehyde by-products from various cellular processes. In osteosarcoma, aldehyde dehydrogenase 1A1has been described as a cancer stem cell marker. Its activity has been found to correlate with metastatic potential and the metastatic phenotype. As such, a more complete understanding of aldehyde dehydrogenase in osteosarcoma will give us a deeper knowledge of its impact on osteosarcoma metastatic potential. Our hope is that this knowledge can be translated into novel antimetastatic therapeutic strategies and thus improve osteosarcoma prognoses.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Belayneh R,Weiss Kdoi
10.1007/978-3-030-43085-6_10subject
Has Abstractpub_date
2020-01-01 00:00:00pages
157-166eissn
0065-2598issn
2214-8019journal_volume
1258pub_type
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