Dietary Fat Intake and Fecundability in 2 Preconception Cohort Studies.

Abstract:

:The association between dietary fat and fertility is not well studied. We evaluated intakes of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids (TFA), ω-3 fatty acids, and ω-6 fatty acids in relation to fecundability in Danish and North American preconception cohort studies. Women who were attempting to become pregnant completed a validated food frequency questionnaire at baseline. Pregnancy status was updated bimonthly for 12 months or until pregnancy. Fecundability ratios (FR) and 95% confidence intervals were estimated using multivariable proportional probabilities regression. Intakes of total fat and saturated, monounsaturated, polyunsaturated, and ω-6 fatty acids were not appreciably associated with fecundability. TFA intake was associated with reduced fecundability in North American women (for the fourth quartile vs. the first, FR = 0.86, 95% confidence interval (CI): 0.71, 1.04) but not Danish women (for the fourth quartile vs. the first, FR = 1.04, 95% CI: 0.86, 1.25), though intake among Danish women was low. In North America, ω-3 fatty acid intake was associated with higher fecundability, but there was no dose-response relationship (among persons who did not use fish oil supplements: for the fourth quartile vs. the first, FR = 1.40, 95% CI: 1.13, 1.73); no association was found in Danish women, among whom low intake was rare. In the present study, high TFA intake and low ω-3 fatty acid intake were associated with reduced fecundity.

journal_name

Am J Epidemiol

authors

Wise LA,Wesselink AK,Tucker KL,Saklani S,Mikkelsen EM,Cueto H,Riis AH,Trolle E,McKinnon CJ,Hahn KA,Rothman KJ,Sørensen HT,Hatch EE

doi

10.1093/aje/kwx204

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

60-74

issue

1

eissn

0002-9262

issn

1476-6256

pii

3863377

journal_volume

187

pub_type

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