Abstract:
:The association between dietary fat and fertility is not well studied. We evaluated intakes of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids (TFA), ω-3 fatty acids, and ω-6 fatty acids in relation to fecundability in Danish and North American preconception cohort studies. Women who were attempting to become pregnant completed a validated food frequency questionnaire at baseline. Pregnancy status was updated bimonthly for 12 months or until pregnancy. Fecundability ratios (FR) and 95% confidence intervals were estimated using multivariable proportional probabilities regression. Intakes of total fat and saturated, monounsaturated, polyunsaturated, and ω-6 fatty acids were not appreciably associated with fecundability. TFA intake was associated with reduced fecundability in North American women (for the fourth quartile vs. the first, FR = 0.86, 95% confidence interval (CI): 0.71, 1.04) but not Danish women (for the fourth quartile vs. the first, FR = 1.04, 95% CI: 0.86, 1.25), though intake among Danish women was low. In North America, ω-3 fatty acid intake was associated with higher fecundability, but there was no dose-response relationship (among persons who did not use fish oil supplements: for the fourth quartile vs. the first, FR = 1.40, 95% CI: 1.13, 1.73); no association was found in Danish women, among whom low intake was rare. In the present study, high TFA intake and low ω-3 fatty acid intake were associated with reduced fecundity.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Wise LA,Wesselink AK,Tucker KL,Saklani S,Mikkelsen EM,Cueto H,Riis AH,Trolle E,McKinnon CJ,Hahn KA,Rothman KJ,Sørensen HT,Hatch EEdoi
10.1093/aje/kwx204subject
Has Abstractpub_date
2018-01-01 00:00:00pages
60-74issue
1eissn
0002-9262issn
1476-6256pii
3863377journal_volume
187pub_type
杂志文章abstract::The aim of this study was to determine whether there was a relation between male exposure to pesticides and the amount of time needed to conceive (time to pregnancy) for farmers and agricultural workers in France and Denmark. The authors used retrospective studies to compare the time to pregnancy of couples in which t...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/oxfordjournals.aje.a009975
更新日期:1999-07-15 00:00:00
abstract::Data derived from laboratory investigations suggest that a number of dietary variables may contribute to bladder carcinogenesis. Although bladder cancer is the fourth leading cause of cancer in men in the United States, dietary studies are few. The authors examined the relations between intakes of macro- and micronutr...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/152.12.1145
更新日期:2000-12-15 00:00:00
abstract::Within the past decade, the infection control nurse (ICN) has become an important element in organized infection surveillance and control programs. Before 1970, only a few hospitals (6%) had an ICN, but, by 1977, over 80% had hired at least one ICN, the majority of those hospitals having done so since 1973. To determi...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112936
更新日期:1980-05-01 00:00:00
abstract::This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free dermatologic controls who had had noncancerous skin disorders diagnosed bet...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117297
更新日期:1994-10-01 00:00:00
abstract::Although coronary heart disease (CHD) is currently the leading cause of death among American Indians, information on the prevalence of CHD and its association with known cardiovascular risk factors is limited. The Strong Heart Study was initiated in 1988 to quantify cardiovascular disease and its risk factors among th...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117632
更新日期:1995-08-01 00:00:00
abstract::We used full-system-estimation instrumental-variables simultaneous equations modeling (IV-SEM) to examine physical activity relative to body mass index (BMI; weight (kg)/height (m)(2)) using 25 years of data (1985/1986 to 2010/2011) from the Coronary Artery Risk Development in Young Adults (CARDIA) Study (n = 5,115; a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww010
更新日期:2016-09-15 00:00:00
abstract::Sibling and twin study designs provide control for confounding factors that are typically unmeasured in traditional cohort studies. Using nationally representative data from the National Longitudinal Study of Adolescent Health collected at 3 visits during 1994-2002, the authors evaluated the longitudinal association b...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq169
更新日期:2010-09-01 00:00:00
abstract::Obesity (body mass index >or=30 kg/m(2)) is a growing urban health concern, but few studies have examined whether, how, or why obesity prevalence has changed over time within cities. This study characterized the individual- and neighborhood-level determinants and distribution of obesity in New York City from 2003 to 2...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp458
更新日期:2010-04-01 00:00:00
abstract::Some researchers have recently questioned the validity of associations between birth weight and health in later life. They argue that these associations might be due in part to inappropriate statistical adjustment for variables on the causal pathway (such as current body size), which creates an artifactual statistical...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwi002
更新日期:2005-01-01 00:00:00
abstract::Accurate measurement of central fat patterning is difficult to obtain by conventional anthropometry. Direct measurement of intra-abdominal fat area by magnetic resonance imaging, while accurate, is impractical for large-scale observational studies. This report examines the sex-specific associations of conventional ant...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008934
更新日期:1996-08-15 00:00:00
abstract::The term shoe-leather epidemiology is often synonymous with field epidemiology or intervention epidemiology. All 3 terms imply investigations initiated in response to urgent public health problems and for which the investigative team does much of its work in the field (i.e., outside the office or laboratory). Alexande...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq252
更新日期:2010-09-15 00:00:00
abstract::Power considerations for trials evaluating vaccines against infectious diseases are complicated by indirect protective effects of vaccination. While cluster-randomized controlled trials (cRCTs) are less statistically efficient than individually randomized controlled trials (iRCTs), a cRCT's ability to measure direct a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwy047
更新日期:2018-08-01 00:00:00
abstract::The association between standardized cancer mortality rate ratios from 1969-1978 and dietary practices was examined in an ecologic study of the 24 counties of Sweden by means of several independent data sources. The study supports the hypothesis that a high intake of cereal fiber protects against colorectal cancer (r ...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.aje.a114789
更新日期:1988-01-01 00:00:00
abstract::In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.5.478
更新日期:2002-03-01 00:00:00
abstract::Between 1977 and 1981, there were 4.9 episodes of community-acquired bacteremia and 5.1 episodes of hospital-acquired bacteremia per 1,000 patients in the four major hospitals of one metropolitan area. Case fatality rates were 30.1 per cent based on deaths due to all causes and 14.7 per cent based on deaths attributed...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114205
更新日期:1986-01-01 00:00:00
abstract::Some reports indicate that exposure to specific polychlorinated biphenyl (PCB) congeners is related to breast cancer risk. The authors recruited participants in a case-control study from October 1994 to March 1997 to assess the relation between breast cancer risk and concentrations of 14 PCB congeners measured in plas...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.7.629
更新日期:2002-04-01 00:00:00
abstract::Risk factors for fibroadenoma were examined in a case-control study involving 117 fibroadenoma cases ascertained by a major private pathology laboratory in Adelaide, Australia, between January 1983 and October 1985. For each case a population control was randomly selected from the electoral roll in Adelaide and matche...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116278
更新日期:1992-02-01 00:00:00
abstract::A single nucleotide polymorphism, - 160C-->A, has been identified in the promoter region of the E-cadherin gene and has been shown to alter its transcriptional activity. To assess susceptibility of -160A allele carriers to seven types of cancers, the authors conducted a comprehensive meta-analysis, up to November 2006...
journal_title:American journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/aje/kwm264
更新日期:2008-01-01 00:00:00
abstract::The authors examined the impact of cumulative neighborhood risk of psychosocial stress on allostatic load (AL) among adolescents as a mechanism through which life stress, including neighborhood conditions, may affect health and health inequities. They conducted multilevel analyses, weighted for sampling and propensity...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kws185
更新日期:2012-10-01 00:00:00
abstract::Difficulties inherent in the identification of immune correlates of protection or severe disease have challenged the development and evaluation of dengue vaccines. There persist substantial gaps in knowledge about the complex effects of age and sequential dengue virus (DENV) exposures on these correlations. To address...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwaa008
更新日期:2020-07-01 00:00:00
abstract::Soft drinks and other sweetened beverages may contribute to risk of type 2 diabetes and obesity. However, research has not addressed higher risk and Asian populations. The authors examined the association between soft drinks and juice and the risk of type 2 diabetes among Chinese Singaporeans enrolled in a prospective...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp452
更新日期:2010-03-15 00:00:00
abstract::Low birth weight of offspring has been associated with increased risk of maternal cardiovascular mortality, and cardiovascular risk factors measured within pregnancy have been related to offspring birth weight. It is not clear whether cardiovascular risk factors assessed prior to pregnancy are associated with the offs...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm272
更新日期:2007-12-15 00:00:00
abstract::This study examined individual and household socioeconomic status (SES) in relation to phenotypes of neural tube defects, orafacial clefts, and conotruncal heart defects using data from the National Birth Defects Prevention Study with 2,551 nonmalformed liveborn controls and 1,841 cases delivered in 1997-2000. The ind...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwm283
更新日期:2008-01-15 00:00:00
abstract::Sequences of treatments that adapt to a patient's changing condition over time are often needed for the management of chronic diseases. An adaptive treatment strategy (ATS) consists of personalized treatment rules to be applied through the course of a disease that input the patient's characteristics at the time of dec...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwz272
更新日期:2020-05-05 00:00:00
abstract::The methods used for selecting subjects yield three types of case-control studies: 1) incident cases are compared to non-cases chosen to be representative of the exposure distribution among the person-years which produced the cases. In this type of study the exposure-odds ratio equals the incidence density ratio; 2) i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112614
更新日期:1978-09-01 00:00:00
abstract::A recent cohort mortality study of 19,608 male employees of a major Texas chemical production facility had suggested that they might be at higher risk of lung cancer compared with the male population of the United States or Texas but not with the male population of the five-county area in which they reside. An occupat...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114370
更新日期:1986-07-01 00:00:00
abstract::In the summer of 1991, four inmates from prison A in Upstate New York died of multi-drug-resistant tuberculosis. To determine the extent of resistant tuberculosis at prison A and transmission patterns, the authors interviewed staff and reviewed medical records and inmate movement histories. Contact investigation resul...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117222
更新日期:1994-07-15 00:00:00
abstract::Increased lung cancer risks among hairdressers were observed in large registry-based cohort studies from Scandinavia, but these studies could not adjust for smoking. Our objective was to evaluate the lung cancer risk among hairdressers while adjusting for smoking and other confounders in a pooled database of 16 case-c...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt119
更新日期:2013-11-01 00:00:00
abstract::In view of the carcinogenic potential and widespread use of conjugated estrogens (CEs), this study evaluated patterns and determinants of oral ambulatory CE use. Among 1273 women 30 to 69 years of age interviewed in Greater-Boston hospitals, there were 161 (13%) ever-users of CEs; 88 (7%) had used the drug within the ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112731
更新日期:1979-06-01 00:00:00
abstract::The relationship of the risk of cancer and death to total serum cholesterol was studied in a random population sample from two counties of Eastern Finland. Data on total serum cholesterol were recorded between February and April 1972 for 3745 men and 4221 women aged 30 to 59 years who had no history of cancer, diabete...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113445
更新日期:1982-10-01 00:00:00