Abstract:
:Difficulties inherent in the identification of immune correlates of protection or severe disease have challenged the development and evaluation of dengue vaccines. There persist substantial gaps in knowledge about the complex effects of age and sequential dengue virus (DENV) exposures on these correlations. To address these gaps, we were conducting a novel family-based cohort-cluster study for DENV transmission in Kamphaeng Phet, Thailand. The study began in 2015 and is funded until at least 2023. As of May 2019, 2,870 individuals in 485 families were actively enrolled. The families comprise at least 1 child born into the study as a newborn, 1 other child, a parent, and a grandparent. The median age of enrolled participants is 21 years (range 0-93 years). Active surveillance is performed to detect acute dengue illnesses, and annual blood testing identifies subclinical seroconversions. Extended follow-up of this cohort will detect sequential infections and correlate antibody kinetics and sequence of infections with disease outcomes. The central goal of this prospective study is to characterize how different DENV exposure histories within multigenerational family units, from DENV-naive infants to grandparents with multiple prior DENV exposures, affect transmission, disease, and protection at the level of the individual, household, and community.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Anderson KB,Buddhari D,Srikiatkhachorn A,Gromowski GD,Iamsirithaworn S,Weg AL,Ellison DW,Macareo L,Cummings DAT,Yoon IK,Nisalak A,Ponlawat A,Thomas SJ,Fernandez S,Jarman RG,Rothman AL,Endy TPdoi
10.1093/aje/kwaa008subject
Has Abstractpub_date
2020-07-01 00:00:00pages
648-659issue
7eissn
0002-9262issn
1476-6256pii
5714864journal_volume
189pub_type
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