An Innovative, Prospective, Hybrid Cohort-Cluster Study Design to Characterize Dengue Virus Transmission in Multigenerational Households in Kamphaeng Phet, Thailand.

Abstract:

:Difficulties inherent in the identification of immune correlates of protection or severe disease have challenged the development and evaluation of dengue vaccines. There persist substantial gaps in knowledge about the complex effects of age and sequential dengue virus (DENV) exposures on these correlations. To address these gaps, we were conducting a novel family-based cohort-cluster study for DENV transmission in Kamphaeng Phet, Thailand. The study began in 2015 and is funded until at least 2023. As of May 2019, 2,870 individuals in 485 families were actively enrolled. The families comprise at least 1 child born into the study as a newborn, 1 other child, a parent, and a grandparent. The median age of enrolled participants is 21 years (range 0-93 years). Active surveillance is performed to detect acute dengue illnesses, and annual blood testing identifies subclinical seroconversions. Extended follow-up of this cohort will detect sequential infections and correlate antibody kinetics and sequence of infections with disease outcomes. The central goal of this prospective study is to characterize how different DENV exposure histories within multigenerational family units, from DENV-naive infants to grandparents with multiple prior DENV exposures, affect transmission, disease, and protection at the level of the individual, household, and community.

journal_name

Am J Epidemiol

authors

Anderson KB,Buddhari D,Srikiatkhachorn A,Gromowski GD,Iamsirithaworn S,Weg AL,Ellison DW,Macareo L,Cummings DAT,Yoon IK,Nisalak A,Ponlawat A,Thomas SJ,Fernandez S,Jarman RG,Rothman AL,Endy TP

doi

10.1093/aje/kwaa008

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

648-659

issue

7

eissn

0002-9262

issn

1476-6256

pii

5714864

journal_volume

189

pub_type

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