Abstract：
:Despite the lack of clinical data about the role of the endocannabinoid system (ECS) in affective disorders, preclinical work suggests that the ECS is relevant in both with regard to the etiology of depression as well as the mediation of antidepressant effects. We measured the intraindividual levels of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) in the cerebrospinal fluid of 12 patients suffering from a major depressive episode before and after the antidepressant treatment by electroconvulsive therapy (ECT). AEA was significantly elevated after ECT as compared to baseline. The AEA increase positively correlated with the number of individually performed ECT sessions. Although the sample size was small and confounders were not rigorously controlled for, our finding corroborates preclinical work and should encourage further exploration of the involvement of the ECS in depressive disorder.
journal_name
Eur Arch Psychiatry Clin Neurosciauthors
Kranaster L,Hoyer C,Aksay SS,Bumb JM,Leweke FM,Janke C,Thiel M,Lutz B,Bindila L,Sartorius Adoi
10.1007/s00406-017-0789-7subject
Has Abstractpub_date
2017-12-01 00:00:00pages
781-786issue
8eissn
0940-1334issn
1433-8491pii
10.1007/s00406-017-0789-7journal_volume
267pub_type
杂志文章abstract：:The aim of this study was to estimate the prevalence and incidence of mood disorders, anxiety disorders, and stress and adjustment disorders in primary health care in Sweden and to analyse the relationship between socioeconomic and demographic factors and incidence of these disorders. Prevalence and incidence data on ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0422-3
更新日期：2014-04-01 00:00:00
abstract：AIM:This study examined the extent to which fathers' and infants' interaction behavior were related to children's externalizing behavior problems at age 8 and 11 years. METHODS:In a prospective longitudinal study of children at risk for later psychopathology, 72 fathers and their 3-month-old children were videotaped a...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-006-0642-x
更新日期：2006-09-01 00:00:00
abstract：:Thirty inpatients with somatoform disorders were examined with the structured clinical interview SCID for psychiatric lifetime diagnosis. In the present diagnoses, we found a concordance of 63% for somatoform and affective disorders and the lifetime comorbidity of both disorders was 87%. Additionally, patients with so...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02190259
更新日期：1992-01-01 00:00:00
abstract：:The National Institute on Aging-Alzheimer's Association (NIA-AA) clinical research criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) incorporate the use of biomarkers to classify patients according to the likelihood of the presence of AD pathology. The aim of the study was to compare the ris...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0349-0
更新日期：2013-06-01 00:00:00
abstract：:Endophenotypes mediate pathways between genetic variations and the psychiatric phenotype, or share genetic risk with the psychiatric phenotype. Identifying endophenotypes is an important step to unravel disease pathways underlying complex psychiatric phenotypes such as ADHD. Potential viable endophenotypes for ADHD ac...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-019-00993-3
更新日期：2019-09-01 00:00:00
abstract：:Diagnostic checklists for the assessment of DSM-III-R Axis I diagnoses have proven to be a reliable and feasible instrument in research and routine clinical care. Therefore, a checklist for the assessment of the DSM-III-R Personality Disorders (MDCL-P) has been developed. An English version of the MDCL-P is available....
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02191550
更新日期：1992-01-01 00:00:00
abstract：:In recent studies, the glutamate (Glu) level has been quantified using the modified STEAM sequence on 3T MRI. We enrolled 15 healthy volunteers and a group of 51 patients who experienced stroke for the first time and had a good prognosis. The patients with infarction were divided into three groups according to their s...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-011-0209-3
更新日期：2012-02-01 00:00:00
abstract：:Alzheimer's disease (AD) is characterized neuropathologically by the presence of amyloid plaques, neuritic plaques, and neurofibrillary tangles (NFTs). These lesions occur not only in demented individuals with AD but also in non-demented persons. In non-demented individuals, amyloid and neuritic plaques are usually ac...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0449-5
更新日期：2013-11-01 00:00:00
abstract：:Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psy...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,多中心研究
doi：10.1007/s00406-018-0890-6
更新日期：2019-06-01 00:00:00
abstract：:Studies addressing the relationship between a history of obstetric complications (OCs) and neurological abnormalities in schizophrenia have produced contradictory findings. Using a pre-posttreatment design in a neuroleptic-naive sample of psychotic patients, we examined the relationship of a history of OC to primary a...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-006-0653-7
更新日期：2006-10-01 00:00:00
abstract：:Evidence suggests that the anterior cingulate cortex (ACC) plays a key role in the development of posttraumatic stress disorder (PTSD). Owing to the region's highly variable patterns, three different studies of PTSD have yielded inconsistent volume reductions. Accordingly, in order to measure the correct borders and v...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0408-1
更新日期：2013-10-01 00:00:00
abstract：:Preventive endeavours in psychotic disorders have been hampered by many obstacles over the past century. One important barrier has been the corrosive pessimism which has attached to the treatment prospects for schizophrenia in particular since the time of Kraepelin, and the isolation of this disorder from progressive ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s004060050014
更新日期：1998-01-01 00:00:00
abstract：:Previous research on neuropsychological disturbances in first-episode and chronic schizophrenic patients has provided mixed results which can be partially attributed to methodological inconsistencies. For the present study, 70 schizophrenic patients (40 with chronic and 30 with first-episode schizophrenia) were compar...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s004060200006
更新日期：2002-02-01 00:00:00
abstract：:Event-related potentials (ERPs) can serve as markers for cognitive processing stages. Identification of those ERPs altered in schizophrenia offer information about cognitive dysfunction. Auditory evoked potentials (AEPs) were elicited within an oddball paradigm in 35 schizophrenic patients and compared with 35 healthy...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s004060050055
更新日期：1998-01-01 00:00:00
abstract：:This study concerns the validation of an instrument, the SAB2, designed to measure child behaviour and to help identify emotional problems which arise because the child has been a victim of child sexual abuse. Clinically disturbed children, mainstream school children and sexually abused youngsters were assessed. Relia...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02916247
更新日期：1997-01-01 00:00:00
abstract：:Impaired perceptual inference has been suggested to be at the core of positive symptoms in schizophrenia. Apparent motion (AM) is a visual illusion in which perceptual inference gives rise to the experience of a single object moving back and forth when two spatially separated objects are flashed in alternation. Here, ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0344-5
更新日期：2013-04-01 00:00:00
abstract：:The relationship between cannabis and cognitive performance is controversial. While both acute administration and long-term cannabis use impair cognitive performance in healthy subjects, several studies have shown improved cognitive outcomes in patients with schizophrenia spectrum disorders who use cannabis. The aim o...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0404-5
更新日期：2013-12-01 00:00:00
abstract：:Smartphone applications ("apps") may contribute to closing the treatment gap for depression by reaching large populations at relatively low costs. The general public seems open towards the use of apps for mental disorders but less is known about the attitudes of health care professionals. Therefore, the aim of this st...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-018-0974-3
更新日期：2020-03-01 00:00:00
abstract：:Previous research suggests disturbed emotional learning and memory in borderline personality disorder (BPD). Studies investigating the neural correlates of aversive differential delay conditioning in BPD are currently lacking. We aimed to investigate acquisition, within-session extinction, between-session extinction r...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-015-0593-1
更新日期：2016-06-01 00:00:00
abstract：:In this review, we discuss current structural and functional imaging data on ADHD in a neurological and neuroanatomical framework. At present, the literature on adult ADHD is somewhat sparse, and so results from imaging have to therefore be considered mainly from the childhood or adolescence perspective. Most work has...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-006-1005-3
更新日期：2006-09-01 00:00:00
abstract：:The course of obsessive-compulsive disorder (OCD) is variable, ranging from episodic to chronic. We hypothesised that the former course is more likely to be related to bipolar mood disorders. With the use of a specially constructed OCD questionnaire, we studied 135 patients fulfilling DSM-III-R criteria for OCD with a...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s004060050044
更新日期：1998-01-01 00:00:00
abstract：:Circadian rhythm disturbance is highly prevalent in attention deficit hyperactivity disorder (ADHD). Recently, the association between the CLOCK gene and ADHD has been demonstrated in clinical samples, and the CLOCK gene's role was thought to be mediated by rhythm dysregulation. Meanwhile, ADHD has been suggested as t...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0443-y
更新日期：2014-02-01 00:00:00
abstract：:The aim of this study was to evaluate residual symptoms in patients achieving remission according to the consensus criteria and to analyze their potential influence on the patient's outcome one year after discharge. In total, 399 patients suffering from a schizophrenia spectrum disorder were evaluated within a natural...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,多中心研究
doi：10.1007/s00406-014-0528-2
更新日期：2015-03-01 00:00:00
abstract：:Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to current treatment approaches. The glutamatergic system has been implicated in the pathophysiology of schizophrenia and affective disorders. A key component is the dysfunction of the glutamate...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-013-0399-y
更新日期：2013-08-01 00:00:00
abstract：:We performed an updated meta-analysis of randomized double-blind placebo-controlled trials (RCTs) on the effects of varenicline adjuvant therapy for smoking cessation in people with schizophrenia, on the basis of a previous meta-analysis (Tsoi in Cochrane Database Syst Rev 2:CD007253, 2013). We searched PubMed, the Co...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00406-014-0551-3
更新日期：2015-04-01 00:00:00
abstract：:The diagnosis of muscle cramp is based on clinical features. Algorithms are presented for the diagnosis of muscle cramp and cramp syndromes. ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/BF02191149
更新日期：1991-01-01 00:00:00
abstract：:Knowledge on the reliability of family history information is essential for every family study. However, systematic analyses of interinformant reliability of family history information on individual relatives have not yet been published. Consequently, family history information on 1306 first-degree relatives and spous...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s004060050025
更新日期：1998-01-01 00:00:00
abstract：:Decreased availability of serotonin in the central nervous system has been suggested to be a central factor in the pathogenesis of depression. Activation of indoleamine 2-3 dioxygenase following a pro-inflammatory state could reduce the amount of tryptophan converted to serotonin and increase the production of tryptop...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-016-0731-4
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:Risk factors, emergence and accumulation of symptoms in the untreated early course were studied as a basis for understanding the relationship between schizophrenia and depression. MATERIALS AND METHODS:130 representative first admissions for schizophrenia were compared retrospectively with 130 individually m...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-005-0584-8
更新日期：2005-06-01 00:00:00
abstract：:Complaints of sleep disturbances are common among alcohol dependent patients during subacute abstinence. Recovered patients may show persistent sleep abnormalities for months or even years. In the present study we studied the issue whether periodic limb movements in sleep and disturbances of nocturnal respiration are ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-002-0371-8
更新日期：2002-06-01 00:00:00
