Abstract：
BACKGROUND AND AIM:Upper gastrointestinal (UGI) symptoms are common; however, the role of Helicobacter pylori and gastric corpus atrophy in the generation of these symptoms is controversial. The aim of this study was to determine the risk factors for UGI symptoms in adults in an endemic area of H. pylori infection. METHODS:Korean adults who completed questionnaires on the day of serum anti-H. pylori IgG and pepsinogen (PG) assays before UGI endoscopy were included. Gastric corpus atrophy was based on the criteria of a serum PG I/II ratio <3.0 and a PG I <70 ng/ml. RESULTS:Of the 2275 included subjects, 723 (31.8%) had at least one UGI symptom. A total of 374 (16.4%) subjects had multiple symptoms without significant correlations between the symptoms (λ < 0.2). The H. pylori serology assay was positive in 1382 (60.7%) subjects, and gastric corpus atrophy was present in 291 (12.8%). Neither H. pylori seropositivity (p = 0.077) nor gastric corpus atrophy (p = 0.138) was related to the presence of UGI symptoms. Female gender and smoking were independent risk factors for heartburn and upper abdominal pain (all p < 0.001). Furthermore, female gender was the only independent risk factor for multiple UGI symptoms (p < 0.001), globus sensation (p < 0.001), early satiety (p < 0.001), epigastric soreness (p = 0.001), and chest discomfort (p = 0.003). CONCLUSIONS:In an H. pylori seroprevalent population, female gender is the most common risk factor followed by smoking for UGI symptom generation. Neither H. pylori seropositivity nor gastric corpus atrophy is an independent risk factor for UGI symptom generation.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Lee SP,Lee SY,Kim JH,Sung IK,Park HS,Shim CSdoi
10.1007/s10620-017-4529-7subject
Has Abstractpub_date
2017-06-01 00:00:00pages
1561-1570issue
6eissn
0163-2116issn
1573-2568pii
10.1007/s10620-017-4529-7journal_volume
62pub_type
杂志文章abstract：BACKGROUND:Acid reflux has been associated with poor outcomes following lung transplantation. Unlike surgical fundoplication, the role of noninvasive, pharmacologic acid suppression remains uncertain. AIMS:To assess the relationship between post-transplant acid suppression with proton pump inhibitors (PPI) or histamin...
journal_title：Digestive diseases and sciences
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更新日期：2018-02-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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更新日期：1984-01-01 00:00:00
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更新日期：1994-12-01 00:00:00
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更新日期：2009-04-01 00:00:00
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更新日期：1997-07-01 00:00:00
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更新日期：1985-06-01 00:00:00
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更新日期：2007-09-01 00:00:00
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更新日期：2019-01-01 00:00:00
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更新日期：2018-06-01 00:00:00
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更新日期：1986-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF01296499
更新日期：1992-10-01 00:00:00
