Abstract:
OBJECTIVE:Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma. In addition to its classical endocrine character known for hemodynamic regulation, the renin-angiotensin system (RAS) can be associated with inflammation, wound healing, and cancer. The aim of this study was to explore a potential expression of the RAS in BE, with or without the presence of dysplasia. MATERIAL AND METHODS:Biopsy material was prepared for western blotting and immunohistochemistry. Non-BE patients (controls) were compared with BE patients regarding RAS in the squamous epithelium. In the columnar BE mucosa, RAS expression was studied in patients with and without dysplasia. Key components of the 'classical' RAS were assessed: the angiotensin-converting enzyme (ACE) and the angiotensin II subtype 1 and 2 receptors (AT1R and AT2R). RESULTS:The presence of RAS factors was confirmed in the esophageal mucosa of both control and BE patients. ACE protein expression was 48% lower (p = 0.001) whereas AT1R was 45% higher (p = 0.039) in the squamous epithelium of BE patients compared to epithelia from non-BE controls. In the metaplastic intestinal-like epithelium, AT1R expression was 37% higher in BE patients with confirmed dysplasia than in patients without dysplasia (p = 0.009). Immunohistochemistry showed an altered distribution of RAS proteins in BE patients with dysplasia. CONCLUSIONS:The differential RAS expression observed may prove to be useful as a biomarker or a pharmaceutical target.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Bratlie SO,Edebo A,Casselbrant A,Helander HF,Fändriks Ldoi
10.1080/00365521.2016.1174881subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1037-42issue
9eissn
0036-5521issn
1502-7708journal_volume
51pub_type
杂志文章abstract::Serological analysis by radioimunoassay of sera from 297 patients hospitalized with acute non-toxic hepatitis was used for classification according to virus etiology. Radioimmunoassays included tests for hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), antibody to hepatitis A virus (anti-HAV), anti-H...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528209181064
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abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent angiogenic, vascular permeability-enhancing, and calcium-dependent enzyme-modulating cytokine with overexpression in various pathologic disorders, including granulomatous inflammation, tissue repair, delayed hypersensitivity reactions, rheumatoid arthriti...
journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
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更新日期:1989-11-01 00:00:00
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更新日期:2012-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1080/00365521.2019.1672781
更新日期:2019-10-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00365529309098307
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655200750024137
更新日期:2000-03-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00365528009181454
更新日期:1980-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520802078325
更新日期:2008-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
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更新日期:1997-10-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
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更新日期:1996-10-01 00:00:00
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更新日期:2002-11-01 00:00:00
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更新日期:2005-01-01 00:00:00