Abstract:
:Voltage-sensing dyes and voltage-sensing fluorescence proteins have been continually improved and as a result have provided a wealth of insights into neuronal circuits. Further improvements in voltage-sensing dyes and voltage-sensing fluorescence proteins are needed, however, for routine detection of single action potentials across a large number of individual neurons in a large field-of-view of a live mammalian brain. On the other hand, recent experiments and calculations suggest that semiconducting nanoparticles could act as efficient voltage sensors, suitable for the above-mentioned task. This study presents quantum mechanical calculations, including Auger recombination rates, of the quantum-confined Stark effect in membrane-embedded semiconducting nanoparticles, examines their possible utility as membrane voltage sensors, and provide design rules for their structure and composition.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Park K,Weiss Sdoi
10.1016/j.bpj.2016.12.047subject
Has Abstractpub_date
2017-02-28 00:00:00pages
703-713issue
4eissn
0006-3495issn
1542-0086pii
S0006-3495(17)30041-3journal_volume
112pub_type
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