Abstract:
:Under the assumption that vesicles are the anatomic correlate of quantal release, the forces governing the movement of synaptic vesicles inside neurons are analyzed. Semiquantitative calculations are presented to show that a diffuse layer field penetrates a few Debye lengths into the axoplasm. This field binds tightly a monolayer of water to the membrane forming the potential barrier for miniature end-plate potential (mepp) release. The action potential destroys the monolayer and pulls the vesicle to the membrane. The vesicles are brought to the synaptic zone and held there by a Na(+) leak in the synaptic membrane. A stochastic theory of synaptic vesicle release is presented to explain experimental results. The rate of vesicle release is fractionated into a rate of membrane contacts by a vesicle and a rate of vesicle discharge per contact.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Remler MPdoi
10.1016/S0006-3495(73)85973-9subject
Has Abstractpub_date
1973-02-01 00:00:00pages
104-17issue
2eissn
0006-3495issn
1542-0086pii
S0006-3495(73)85973-9journal_volume
13pub_type
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/S0006-3495(98)74022-6
更新日期:1998-02-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(93)81385-7
更新日期:1993-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.bpj.2017.11.3812
更新日期:2018-02-27 00:00:00
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pub_type: 杂志文章
doi:10.1016/S0006-3495(79)85274-1
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.104.051748
更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-06-01 00:00:00
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更新日期:1990-10-01 00:00:00
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更新日期:2004-03-01 00:00:00
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更新日期:2006-05-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.106.094425
更新日期:2007-06-15 00:00:00
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更新日期:1998-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-06-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:1971-01-01 00:00:00