Abstract:
:Single epithelial Na+ channels incorporated into planar lipid bilayers were studied to determine the effects of Na concentration on its own conductance. Amiloride-sensitive Na+ channels were obtained from apical membrane vesicles made from A6 cells, a continuous epithelial cell-line derived from amphibian kidney. Single-channel conductance was found to be a saturable function of Na+ concentration, with a Michaelis constant of approximately 17 or 47 mM, for a Gmax of approximately 4 or 44 pS, respectively.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Olans L,Sariban-Sohraby S,Benos DJdoi
10.1016/S0006-3495(84)84082-5subject
Has Abstractpub_date
1984-12-01 00:00:00pages
831-5issue
6eissn
0006-3495issn
1542-0086pii
S0006-3495(84)84082-5journal_volume
46pub_type
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