Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.

abstract：:Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with the T allele. In the ...

journal_title：Acta biochimica Polonica

authors： Saeed HM,Alanazi MS,Alshahrani O,Parine NR,Alabdulkarim HA,Shalaby MA

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to evaluate the therapeutic potential of oxidative stress (OS) reduction by using pyridoindole (PI) antioxidants in adjuvant arthritis (AA). The substances tested were stobadine dipalmitate (STB) and SMe1. AA was used as animal model. The experiments included healthy animals, control arthriti...

journal_title：Acta biochimica Polonica

authors： Ponist S,Mihalova D,Jancinova V,Snirc V,Ondrejickova O,Mascia C,Poli G,Stancikova M,Nosal R,Bauerová K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:MicroRNAs play a crucial role in diabetic peripheral neuropathic pain (DPNP). miR-590-3p is a novel miRNA and involved in multiple diseases. However, the pathological mechanism of miR-590-3p in DPNP needs to be elucidated. MATERIALS AND METHODS:The db/db mice and db/m mice were selected to mimic diabetes an...

journal_title：Acta biochimica Polonica

authors： Wu Y,Gu Y,Shi B

更新日期：2020-12-17 00:00:00

abstract：:Several mammalian enzymes are anchored to the outer surface of the plasma membrane by a covalently attached glycosylphosphatidylinositol (GPI) structure. These include acetylcholinesterase, alkaline phosphatase (AP) and 5'-nucleotidase among other enzymes. Recently, it has been reported that these membrane enzymes can...

journal_title：Acta biochimica Polonica

authors： Sadeghirizi A,Yazdanparast R

更新日期：2007-01-01 00:00:00

abstract：:Short peptides resembling the Helicobacter pylori urease antigen (UreB F8 Ser-Ile-Lys-Glu-Asp-Val-Gln-Phe) with deleted aspartic acid and glutamic acid residues, anchored through a triazine linker via the N-terminal moiety to cellulose plate were prepared. The peptides were used for binding of antibodies from sera of ...

journal_title：Acta biochimica Polonica

authors： Białek M,Grabowski S,Kamiński Z,Kaca W

更新日期：2006-01-01 00:00:00

abstract：:Some properties of the sulphate transport system and the isolation of sulphate permease mutants in E. coli K12 are described. The gene coding for sulphate permease is located in the same region as the cysA gene in Salmonella typhimurium. ...

journal_title：Acta biochimica Polonica

authors： Karbonowska H,Wiater A,Hulanicka D

更新日期：1977-01-01 00:00:00

abstract：:The protective action of quercetin against the pro-oxidant and apoptotic effect of etoposide was investigated in HL-60 cells with a high level of myeloperoxidase (MPO) activity and in cells treated with MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH). Quercetin significantly protected MPO-rich cells against the pr...

journal_title：Acta biochimica Polonica

authors： Papież MA,Krzyściak W

更新日期：2014-01-01 00:00:00

abstract：:Unusual chemical properties of hypermodified nucleosides N6-(threoninocarbonyl)adenosine (t6 A) located at position 37 and 3-(3-amino-3-carboxypropyl)uridine (acp3U) located at position 20:1 have been utilized for the introduction of photoreactive azidonitrophenyl probes to the anticodon loop and to the dihydrouridine...

journal_title：Acta biochimica Polonica

authors： Podkowinski J,Dymarek-Babs T,Gornicki P

更新日期：1989-01-01 00:00:00

abstract：:Advanced oxidation protein products (AOPPs) are protein markers of oxidative stress with pro-inflammatory properties that accumulated in liver cirrhosis. In the present study, we investigated the association between chronic inflammatory response triggered by AOPPs and the severity of liver disease as assessed by the C...

journal_title：Acta biochimica Polonica

authors： Zuwała-Jagiełło J,Pazgan-Simon M,Simon K,Warwas M

更新日期：2011-01-01 00:00:00

abstract：:Transcriptionally active and inactive chromatin fractions were isolated from Physarum polycephalum after depolymerization of chromatin with DNAase II or micrococcal nuclease, followed by fractionation in 5 mM-MgCl2. The active fraction of chromatin comprised up to 21% of nuclear DNA and was enriched 22-fold in the lab...

journal_title：Acta biochimica Polonica

authors： Czupryn M,Toczko K

更新日期：1980-01-01 00:00:00

abstract：:Geranylgeranyl diphosphate (GGPP) synthase was purified to homogeneity from bovine brain in a one-step affinity column procedure. For the construction of the affinity column, a farnesyl diphosphate (FPP) analog, O-(6-amino-1-hexyl)-P-farnesylmethyl phosphonophosphate, was synthesized and linked to the spacer of the ma...

journal_title：Acta biochimica Polonica

authors： Sagami H,Morita Y,Korenaga T,Ogura K

更新日期：1994-01-01 00:00:00

abstract：:Annexins belong to a family of multi-functional membrane- and Ca(2+)-binding proteins. The characteristic feature of these proteins is that they can bind membrane phospholipids in a reversible, Ca(2+)-dependent manner. While animal annexins have been known for a long time and are fairly well characterized, their plant...

journal_title：Acta biochimica Polonica

authors： Talukdar T,Gorecka KM,de Carvalho-Niebel F,Downie JA,Cullimore J,Pikula S

更新日期：2009-01-01 00:00:00

abstract：:Public and private EST (Expressed Sequence Tag) programs provide access to a large number of ESTs from a number of plant species, including Arabidopsis, corn, soybean, rice, wheat. In addition to the homology of each EST to genes in GenBank, information about homology to all other ESTs in the data base can be obtained...

journal_title：Acta biochimica Polonica

authors： Rafalski JA,Hanafey M,Miao GH,Ching A,Lee JM,Dolan M,Tingey S

更新日期：1998-01-01 00:00:00

abstract：:Bacteriophage lambda is not able to lysogenise the Escherichia coli rpoA341 mutant. This mutation causes a single amino acid substitution Lys271Glu in the C-terminal domain of the RNA polymerase alpha subunit (alphaCTD). Our previous studies indicated that the impaired lysogenisation of the rpoA341 host is due to a de...

journal_title：Acta biochimica Polonica

authors： Gabig M,Obuchowski M,Ciesielska A,Latała B,Wegrzyn A,Thomas MS,Wegrzyn G

更新日期：1998-01-01 00:00:00

abstract：:RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are involved in transcription and replication of viral single-stranded RNA g...

journal_title：Acta biochimica Polonica

authors： Borowski P,Niebuhr A,Schmitz H,Hosmane RS,Bretner M,Siwecka MA,Kulikowski T

更新日期：2002-01-01 00:00:00

abstract：:Epidemiological studies have revealed a strong correlation between high intake of fruit and vegetables and low incidence of certain cancers. Micronutrients present in these foods are thought to decrease free radical attack on DNA and hence protect against mutations that cause cancer, but the fine details of the causal...

journal_title：Acta biochimica Polonica

authors： Fillion L,Collins A,Southon S

更新日期：1998-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) cells are highly radiosensitive. Historically, the main modality for NPC has been radiotherapy. Now, to explore a novel and more effective approach to NPC therapy, a combined strategy of suicide gene and radiation was developed. The yeast CDglyTK (yCDglyTK) gene controlled by a synthetic...

journal_title：Acta biochimica Polonica

authors： Tang A,Zhang J,Tang Y,Feng Y,Wu L,Pan Q,Long Z,Dai H,Zhao S,Liu T,Chen Z,Xia K,Xia J

更新日期：2005-11-06 00:00:00

abstract：:We here report the influence of the cell cycle abrogator UCN-01 on RKO human colon carcinoma cells differing in p53 status following exposure to two DNA damaging agents, the topoisomerase inhibitors etoposide and camptothecin. Cells were treated with the two drugs at the IC90 concentration for 24 h followed by post-in...

journal_title：Acta biochimica Polonica

authors： Bozko P,Larsen AK,Raymond E,Skladanowski A

更新日期：2002-01-01 00:00:00

abstract：:The primary hepatocytes culture is still one of the main challenges in toxicology studies in the drug discovery process, development of in vitro models to study liver function, and cell-based therapies. Isolated hepatocytes display a rapid decline in viability and liver-specific functions including albumin production,...

journal_title：Acta biochimica Polonica

authors： Wencel A,Zakrzewska KE,Samluk A,Noszczyk BH,Pijanowska DG,Pluta KD

更新日期：2017-01-01 00:00:00

abstract：:1. The activity of trypsin inhibitors in lung and pancreas increased with age of the animals. 2. In foetal lung the activity of the basic Kunitz-type inhibitor was 1% that, and in calf lung 5-30% that, found in adult animals. 3. In foetal pancreas the basic Kunitz-type inhibitor was not detected, and in calf pancreas ...

journal_title：Acta biochimica Polonica

authors： Wilusz T,Wilimowska-Pelc A,Mejbaum-Katzenellenbogen W

更新日期：1976-01-01 00:00:00

abstract：:All organisms are exposed to numerous stress factors, which include harmful xenobiotics. The diversity of these compounds is enormous, thus in the course of evolution diverse biological defense mechanisms at various levels of organization have developed. One of them engages an evolutionarily conserved family of transp...

journal_title：Acta biochimica Polonica

authors： Szczygieł M,Markiewicz M,Szafraniec M,Zuziak R,Urbańska K,Fiedor L

更新日期：2017-01-01 00:00:00

abstract：:Fucoxanthin, diadinoxanthin and diatoxanthin are carotenoids found in brown algae and most other heterokonts. These pigments are involved in photosynthetic and photoprotective reactions, and they have many potential health benefits. They can be extracted from diatom Phaeodactylum tricornutum by sonication, extraction ...

journal_title：Acta biochimica Polonica

authors： Tokarek W,Listwan S,Pagacz J,Leśniak P,Latowski D

更新日期：2016-01-01 00:00:00

abstract：:Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cyt...

journal_title：Acta biochimica Polonica

authors： Koczurkiewicz P,Czyż J,Podolak I,Wójcik K,Galanty A,Janeczko Z,Michalik M

更新日期：2015-01-01 00:00:00

abstract：:The presence of the single metals (Cd, Pb, Cu, Zn) induces ROS (reactive oxygen species) production and causes oxidative stress in plants. While applied in two-element combinations, trace metals impact organisms in a more complex way. To assess the resultant effect we treated the pea grown hydroponically with the trac...

journal_title：Acta biochimica Polonica

authors： Malecka A,Piechalak A,Zielińska B,Kutrowska A,Tomaszewska B

更新日期：2014-01-01 00:00:00

abstract：:Potassium permanganate oxidation of pyrimidine bases is often used to probe single-stranded regions in functional DNA-protein complexes. However, so far reactivity of these bases in double-stranded DNA has not been studied quantitatively. We have investigated the kinetics of oxidation of pyrimidines in supercoiled pDS...

journal_title：Acta biochimica Polonica

authors： Loziński T,Wierzchowski KL

更新日期：2001-01-01 00:00:00

abstract：:Two winter triticale (x Triticosecale Wittmack) model cultivars: Hewo (tolerant to pink snow mould) and Magnat (sensitive) were used to test the effect of cold-hardening (4 weeks at 4°C) on soluble ≤50 kDa protein profiles of the seedling leaves. The presence and abundance of individual proteins were analysed via two-...

journal_title：Acta biochimica Polonica

authors： Golebiowska GJ,Bonar E,Emami K,Wędzony M

更新日期：2019-09-10 00:00:00

abstract：:Restricting food intake to a level below that consumed voluntarily (85%, 70% and 50% of the ad libitum energy intake for 3 or 30 days) and re-feeding ad libitum for 48 h results in an increase of malic enzyme (ME) gene expression in rat white adipose tissue. The increase of ME gene expression was much more pronounced ...

journal_title：Acta biochimica Polonica

authors： Stelmanska E,Korczynska J,Swierczynski J

更新日期：2004-01-01 00:00:00

abstract：:X-ray crystallography provides important insights into structure-function relationship in biomolecules. However, protein crystals are usually hard to obtain which hinders our understanding of multiple important processes. Crystallization requires large amount of protein sample, whereas recombinant proteins are often u...

journal_title：Acta biochimica Polonica

authors： Janczak M,Bukowski M,Górecki A,Dubin G,Dubin A,Wladyka B

更新日期：2015-01-01 00:00:00

abstract：:Little is known about the molecular background of clinical variability of Charcot-Marie-Tooth type 1A (CMT1A) disease and hereditary neuropathy with liability to pressure palsies (HNPP). The CMT1A and HNPP disorders result from duplication and deletion of the PMP22 gene respectively. In a series of studies performed o...

journal_title：Acta biochimica Polonica

authors： Sinkiewicz-Darol E,Kabzińska D,Moszyńska I,Kochański A

更新日期：2010-01-01 00:00:00

abstract：:The mammalian deoxyribonucleoside kinases thymidine kinase 1 and 2, deoxycytidine kinase and deoxyguanosine kinase phosphorylate deoxyribonucleosides and provide an alternative to de novo synthesis of DNA precursors. Their activities are essential for activation of several chemotherapeutically important nucleoside ana...

journal_title：Acta biochimica Polonica

authors： Johansson NG,Eriksson S

更新日期：1996-01-01 00:00:00