Abstract:
:Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations (more than 100 µM) saponins exert cytotoxic and haemolytic effects via permeabilization of the cell membranes. Noteworthy, the inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations. Saponins might affect the expression of genes associated with malignancy. These alterations are directly related to the invasive phenotype of cancer cells and depend on "cellular context". It illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells. Here, we discuss the hallmarks of anti-cancer activity of saponins with the particular emphasis on anti-invasive effect of diverse groups of saponins that have been investigated in relation to tumor therapy.
journal_name
Acta Biochim Poljournal_title
Acta biochimica Polonicaauthors
Koczurkiewicz P,Czyż J,Podolak I,Wójcik K,Galanty A,Janeczko Z,Michalik Mdoi
10.18388/abp.2015_1089subject
Has Abstractpub_date
2015-01-01 00:00:00pages
383-93issue
3eissn
0001-527Xissn
1734-154Xpii
2015_1089journal_volume
62pub_type
杂志文章,评审abstract::The role of Survivin in the pathogenesis of leukemia was explored in order to discover the effective avenues for gene therapy. Most primary leukemia cells isolated from patients as well as three leukemia cell lines (HL-60, K562, and U937) all expressed Survivin gene. To investigate the relationship between Survivin an...
journal_title:Acta biochimica Polonica
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doi:10.18388/abp.2015_1050
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doi:10.18388/abp.2019_2804
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.18388/abp.2019_2814
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:10.18388/abp.2015_1106
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2016_1481
更新日期:2017-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2017_1622
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doi:
更新日期:1999-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2019_2883
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pub_type: 杂志文章
doi:0350041239
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journal_title:Acta biochimica Polonica
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doi:10.18388/abp.2015_1221
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