Abstract:
:This study aimed to evaluate the antidotal potency of tenocyclidine (TCP) that probably might protect acetylcholinesterase (AChE) in the case of organophosphate poisoning. TCP was tested alone as a pretreatment or in combination with atropine as a therapy in rats poisoned with (1/4) and (1/2) of LD(50) of soman. Possible genotoxic effects of TCP in white blood cells and brain tissue were also studied. Results were compared with previous findings on the adamantyl tenocyclidine derivative TAMORF. TCP given alone as pretreatment, 5 min before soman, seems to be superior in the protection of cholinesterase (ChE) catalytic activity in the plasma than in brain, especially after administration of the lower dose of soman. Plasma activities of the enzyme after a joint treatment with TCP and soman were significantly increased at 30 min (P<0.001) and 24 h (P=0.0043), as compared to soman alone. TCP and atropine, given as therapy, were more effective than TCP administered alone as a pretreatment. The above therapy significantly increased activities of the enzyme at 30 min (P=0.046) and 24 h (P<0.001), as compared to controls treated with (1/4) LD(50) of soman alone. Using the alkaline comet assay, acceptable genotoxicity of TCP was observed. However, the controversial role of TCP in brain protection of soman-poisoned rats should be studied further.
journal_name
Acta Biochim Poljournal_title
Acta biochimica Polonicaauthors
Petek MJ,Berend S,Kopjar N,Zeljezić D,Mladinić M,Radić B,Vrdoljak ALsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
97-105issue
1eissn
0001-527Xissn
1734-154Xpii
20081589journal_volume
55pub_type
杂志文章abstract::The endogenous electric field may provide an important signal for directional cell migration during cancer metastasis but the mechanism of cell electrotaxis is poorly understood. It was postulated that microtubules play a central role in the polarization and directional migration of several types of cells. In this pap...
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journal_title:Acta biochimica Polonica
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更新日期:2009-01-01 00:00:00
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更新日期:2006-01-01 00:00:00
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doi:024903597
更新日期:2002-01-01 00:00:00
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doi:
更新日期:2005-01-01 00:00:00
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journal_title:Acta biochimica Polonica
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更新日期:1984-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00