Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis.

Abstract:

:The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.

journal_name

Acta Biochim Pol

journal_title

Acta biochimica Polonica

authors

Micota B,Sadowska B,Podsędek A,Redzynia M,Różalska B

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

385-8

issue

2

eissn

0001-527X

issn

1734-154X

pii

2013_651

journal_volume

61

pub_type

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