The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide.

abstract：:The amniotic fluid (AF) was fractionated by dialysis, gel filtration and SDS/PAGE, and submitted to the assay of collagenous constituents. The collagenous character of peptides and proteins of amniotic fluid was confirmed by hydroxyproline (Hyp) assay and treatment with bacterial collagenase followed by electrophoresi...

journal_title：Acta biochimica Polonica

authors： Gogiel T,Bielecki DA,Bańkowski E

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study was to analyse the correlation between HPV16 E6 variants and the physical status of viral genome (integrated, mixed, episomal) among patients with cervical cancer (n=40) and low-grade squamous intraepithelial lesions - LSIL (n=40). The study was performed on 80 HPV16 positive samples. HPV16 E6 va...

journal_title：Acta biochimica Polonica

authors： Szostek S,Zawilinska B,Klimek M,Kosz-Vnenchak M

更新日期：2017-01-01 00:00:00

abstract：:We examined the molecular basis of factor IX deficiency in 53 unrelated Polish patients with hemophilia B. Heteroduplex analysis and direct sequencing of polymerase chain reaction (PCR) products were applied to identify the gene defect. Forty-three different point mutations were detected in the factor IX gene of 47 pa...

journal_title：Acta biochimica Polonica

authors： Wulff K,Bykowska K,Lopaciuk S,Herrmann FH

更新日期：1999-01-01 00:00:00

abstract：:People are exposed to heavy metals both in an occupational and natural environment. The most pronounced effects of heavy metals result from their interaction with cellular genetic material packed in form of chromatin. Heavy metals influence chromatin, mimicking and substituting natural microelements in various process...

journal_title：Acta biochimica Polonica

authors： Sas-Nowosielska H,Pawlas N

更新日期：2015-01-01 00:00:00

abstract：:A new enzymatic activity, which catalyses formation in vitro of di-O-(indole-3-acetyl)-D-glucose from 1-O-(indole-3-acetyl)-beta-D-glucose has been found in extracts of Zea mays seedlings. The structure of di-O-(indole-3-acetyl)-D-glucose, not as yet described, has been assigned by GC-MS, 1H NMR and ammonolysis. ...

journal_title：Acta biochimica Polonica

authors： Szmidt-Jaworska A,Kesy J,Kopcewicz J

更新日期：1997-01-01 00:00:00

abstract：:Asparaginases catalyze the hydrolysis of asparagine to aspartic acid and ammonia. Enzymes with asparaginase activity play an important role both in the metabolism of all living organisms as well as in pharmacology. The main goal of this paper is to attempt a classification of all known enzymes with asparaginase activi...

journal_title：Acta biochimica Polonica

authors： Borek D,Jaskólski M

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is a chronic, heterogenous inflammatory disease of unclear pathogenesis. JIA is hypothesized to be linked to a defective immune regulation. Anti-inflammatory cytokines belong to the best known regulatory factors. T-regulatory cells are a crucial cellular component of immun...

journal_title：Acta biochimica Polonica

authors： Sznurkowska K,Boćkowska M,Zieliński M,Plata-Nazar K,Trzonkowski P,Liberek A,Kamińska B,Szlagatys-Sidorkiewicz A

更新日期：2018-01-01 00:00:00

abstract：:Pharmaceutical substances and their residues are increasingly present in the environment. Therefore, attempts at their removal are made by using different processes. Increasingly important among these processes are those modeled on natural phenomena which occur in wetland ecosystems, called technical scale constructed...

journal_title：Acta biochimica Polonica

authors： Nowrotek M,Ziembińska-Buczyńska A,Miksch K

更新日期：2015-01-01 00:00:00

abstract：:The fuzzy oil drop model suggests that the tertiary conformation of a protein - particularly a globular one - can be likened to a spherical micelle. During the folding process, hydrophilic residues are exposed on the surface, while hydrophobic residues are retained inside the protein. The resulting hydrophobicity dist...

journal_title：Acta biochimica Polonica

authors： Ptak-Kaczor M,Banach M,Konieczny L,Roterman I

更新日期：2019-11-20 00:00:00

abstract：:The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of Lu...

journal_title：Acta biochimica Polonica

authors： Djaber N,Ounaceur LS,Moubine BN,Khaldi T,Rouag M,Berrouague S,Amara H,Taibi F,Boumendjel M,Boumendjel A,Messarah M

更新日期：2020-03-18 00:00:00

abstract：:beta-Secretase, a beta-site amyloid precursor protein (APP) cleaving enzyme (BACE), participates in the secretion of beta-amyloid peptides (Abeta), the major components of the toxic amyloid plaques found in the brains of patients with Alzheimer's disease (AD). According to the amyloid hypothesis, accumulation of Abeta...

journal_title：Acta biochimica Polonica

authors： Nawrot B

更新日期：2004-01-01 00:00:00

abstract：:The effect of vitamin D3 on the activity of different forms of alkaline phosphatase as well as on the ability of their subunits to form phosphorylated intermediates in the presence of [gamma-32P]ATP was studied. In experiments with rats fed a diet enriched in vitamin D3 phosphatase F3 activity was doubled and the radi...

journal_title：Acta biochimica Polonica

authors： Dupuis Y,Tardivel S,Ranivosoa A,Fournier P,Razanamaniraka L,Zelazowska E,Porembska Z

更新日期：1990-01-01 00:00:00

abstract：:Temporin A (TA) and a cecropin A-temporin A hybrid peptide (CATA) were synthesized and assayed for their hemolytic, anticoagulant, and antifungal properties. CATA retains significant antifungal activity, is less hemolytic than TA, and inhibits blood coagulation. These results recommend further studies of the biologica...

journal_title：Acta biochimica Polonica

authors： Wade D,Silveira A,Rollins-Smith L,Bergman T,Silberring J,Lankinen H

更新日期：2001-01-01 00:00:00

abstract：:In this paper transcriptional factor IIIA (TFIIIA) has been used as a probe for identity of three-dimensional-structure of eukaryotic 5S rRNAs. I was interested in finding a common motif in plant and Xenopus 5S rRNAs for TFIIIA recognition. I found that the two eukaryotic 5S rRNAs (from wheat germ and lupin seeds) are...

journal_title：Acta biochimica Polonica

authors： Barciszewska MZ

更新日期：1994-01-01 00:00:00

abstract：:The presence of the single metals (Cd, Pb, Cu, Zn) induces ROS (reactive oxygen species) production and causes oxidative stress in plants. While applied in two-element combinations, trace metals impact organisms in a more complex way. To assess the resultant effect we treated the pea grown hydroponically with the trac...

journal_title：Acta biochimica Polonica

authors： Malecka A,Piechalak A,Zielińska B,Kutrowska A,Tomaszewska B

更新日期：2014-01-01 00:00:00

abstract：:Despite senescence-induced chlorophyll depletion in plants has been widely studied, the enzymatic background of this physiologically regulated process still remains highly unclear. The purpose of this study was to determine selected biochemical properties of partially purified fractions of chlorophyllase (Chlase, chlo...

journal_title：Acta biochimica Polonica

authors： Sytykiewicz H,Sprawka I,Czerniewicz P,Sempruch C,Leszczyński B,Sikora M

更新日期：2013-01-01 00:00:00

abstract：:Leukemia is a particular type of cancer characterized by the failure of cell death or disability in differentiation of hematopoietic cells. Chronic myelogenus leukemia (CML) is the most studied kind of this cancer. In this study, anti-cancer effect of dihydro-pyranochromenes derivatives were investigated in the human ...

journal_title：Acta biochimica Polonica

authors： Rahimi R,Mahdavi M,Pejman S,Zare P,Balalaei S

更新日期：2015-01-01 00:00:00

abstract：:An analysis has been made, with the aid of 1H NMR spectroscopy, of the solution conformation of the known antimetabolite, 9-beta-D-xylofuranosyladenine (xyloA), and of its 8-bromo analogue. For xyloA, the results point to a strong preference for the sugar ring of the conformation type N (C(3') endo), a relatively low ...

journal_title：Acta biochimica Polonica

authors： Ekiel I,Shugar D

更新日期：1979-01-01 00:00:00

abstract：:Secondary structures of the N-terminal fragments of 18 preproteins were analysed taking advantage of the method of Chou & Fasman (Biochemistry, 1974, 13, 222-245; J. Mol. Biol., 1977, 115, 135-175) and the known sequences of amino acid residues. Positions of alpha-helices, beta-sheet structures and beta-turns in the l...

journal_title：Acta biochimica Polonica

authors： Tłomak P,Nowak K

更新日期：1981-01-01 00:00:00

abstract：:The use of nucleotides and their analogs in the pharmacological studies of nucleotide receptors (P2 class) should be preceded by detailed studies on their degradation connected with ecto-enzymes of a given cell type. In the present studies we have analyzed stability of some phosphorothioate and phosphonate analogs of ...

journal_title：Acta biochimica Polonica

authors： Gendaszewska-Darmach E,Maszewska M,Zakłos M,Koziołkiewicz M

更新日期：2003-01-01 00:00:00

abstract：:The capabilities of porcine adrenal cortex mitochondria to oxidize glycerol-3-phosphate (GP) were studied. In comparison with bovine adrenal cortex mitochondria, porcine mitochondria oxidized GP about three times more actively (18.9 vs 6.1 nmol O(2)/min per mg protein in the presence of ADP) and the activity of mitoch...

journal_title：Acta biochimica Polonica

authors： Popinigis J,Antosiewicz J,Kaczor JJ,Rauchová H,Lenaz G

更新日期：2004-01-01 00:00:00

abstract：:Human mitochondrial polynucleotide phosphorylase (hPNPase) is an exoribonuclease localized in mitochondria. The exact physiological function of this enzyme is unknown. Recent studies have revealed the existence of a relationship between induction of hPNPase mRNA and both cellular senescence and growth arrest of melano...

journal_title：Acta biochimica Polonica

authors： Gewartowski K,Tomecki R,Muchowski L,Dmochow Ska A,Dzwonek A,Malecki M,Skurzak H,Ostrowski J,Stepien PP

更新日期：2006-01-01 00:00:00

abstract：:Trans-diamminedichloroplatinum(II) (trans-DDP) forms with DNA at 37 degrees C, more numerous interstrand cross-links than cis-DDP in the isolated DNA and DNA in the chromatin complex. An increase in the temperature to 42.5 degrees C had no effect on the interstrand cross-links of DND-Pt-DNA formed by the two isomers, ...

journal_title：Acta biochimica Polonica

authors： Kulamowicz I,Walter Z,Krupa R

更新日期：1990-01-01 00:00:00

abstract：:Although both uveal (UM) and cutaneous (CM) melanoma cells derive from the transformed melanocytes, their biology varies significantly in several aspects. Malignant transformation is frequently associated with alternations in cell glycosylation, in particular those concerning branched complex-type N-glycans. These cha...

journal_title：Acta biochimica Polonica

authors： Pocheć E,Rydlewska M,Przybyło M,Lityńska A

更新日期：2015-01-01 00:00:00

abstract：:Isoelectric focusing of homogenous arylsulfatase B from human placenta pointed to the presence of enzymatically active and inactive forms of high pI (pH 9-8) and of lower pI (pH 6.5-5.5). Glycan chain analysis performed with the use of a Glycan Differentiation Kit showed that basic forms of arylsulfatase B from human ...

journal_title：Acta biochimica Polonica

authors： Laidler P,Gałka-Walczak M,Lityńska A

更新日期：1995-01-01 00:00:00

abstract：:Computer modelling related to the real dimensions of both the whole filament and the myosin molecule subfragments has revealed two alternative modes for myosin molecule packing which lead to the head disposition similar to that observed by EM on the surface of the cross-bridge zone of the relaxed vertebrate skeletal m...

journal_title：Acta biochimica Polonica

authors： Skubiszak L,Kowalczyk L

更新日期：2002-01-01 00:00:00

abstract：:In the post-mitochondrial fraction of murine LBN/b leukemic cells, four fractions with DNA polymerase activity (I, II, III, IV) were found. On the basis of ion exchanger affinity and poly(A), poly(C) and poly(Cm) replication ability, fraction I was classified as RNA-directed DNA polymerase of viral origin. On the basi...

journal_title：Acta biochimica Polonica

authors： Siedlecki JA,Mikke R,Zmudzka B

更新日期：1976-01-01 00:00:00

abstract：:1. The interaction of copper(II) with inosine, 2'-deoxyinosine, 1-methylinosine, 7-deazainosine, 6-methoxypurine riboside and IMP was examined. 2. Copper binds with the purine base of the nucleosides, and in IMP also with the phosphate group. Non interaction with ribose hydroxyl groups was observed. 3. In non-aqueous ...

journal_title：Acta biochimica Polonica

authors： Maskos K

更新日期：1978-01-01 00:00:00

abstract：:Potassium permanganate oxidation of pyrimidine bases is often used to probe single-stranded regions in functional DNA-protein complexes. However, so far reactivity of these bases in double-stranded DNA has not been studied quantitatively. We have investigated the kinetics of oxidation of pyrimidines in supercoiled pDS...

journal_title：Acta biochimica Polonica

authors： Loziński T,Wierzchowski KL

更新日期：2001-01-01 00:00:00

abstract：:All organisms are exposed to numerous stress factors, which include harmful xenobiotics. The diversity of these compounds is enormous, thus in the course of evolution diverse biological defense mechanisms at various levels of organization have developed. One of them engages an evolutionarily conserved family of transp...

journal_title：Acta biochimica Polonica

authors： Szczygieł M,Markiewicz M,Szafraniec M,Zuziak R,Urbańska K,Fiedor L

更新日期：2017-01-01 00:00:00