Serum leptin changes with metformin treatment in polycystic ovarian syndrome: correlation with ovulation, insulin and testosterone levels.

abstract：:Endometriosis is defined by presence of endometrial-like-tissue outside the uterus. Recently, ectopic endometriotic lesions have been suggested to originate by abnormal differentiation of endometrial mesenchymal stem cells (eMSCs). MicroRNAs (miRNAs) play an important role in the pathophysiology of endometriosis. Thro...

journal_title：EXCLI journal

authors： Abdel-Rasheed M,Nour Eldeen G,Mahmoud M,ElHefnawi M,Abu-Shahba N,Reda M,Elsetohy K,Nabil M,Elnoury A,Taha T,Azmy O

更新日期：2017-06-14 00:00:00

abstract：:Some debates exist regarding the association of diabetes mellitus (DM) with COVID-19 infection severity and mortality. In this study, we aimed to describe and compare the clinical characteristics and outcomes of hospitalized COVID-19 patients with and without DM. In this single-centered, retrospective, observational s...

journal_title：EXCLI journal

authors： Mansour A,Sajjadi-Jazi SM,Kasaeian A,Khosravi B,Sorouri M,Azizi F,Rajabi Z,Motamedi F,Sirusbakht A,Eslahi M,Mojtabbavi H,Sima AR,Radmard AR,Mohajeri-Tehrani MR,Abdollahi M

更新日期：2020-11-16 00:00:00

abstract：:Toxoplasma gondii is a common protozoan parasite, which infects warm-blooded mammals, including mice and humans, throughout the world. The negative effects of T. gondii infection on the human reproductive system have been documented, especially in females. However, only few studies have examined the effects of T. gond...

journal_title：EXCLI journal

authors： Saki J,Sabaghan M,Arjmand R,Teimoori A,Rashno M,Saki G,Shojaee S

更新日期：2020-08-24 00:00:00

abstract：:We present the case of a 77 year old male patient with metastatic pancreatic neuroendocrine tumor (NET). The patient was initially treated by extensive surgical resection that however, led to severe complications with delayed recovery. During follow-up, a number of new liver metastases were detected, one of which was ...

journal_title：EXCLI journal

authors： Ataeinia B,Loberg C,Kravets H,Beheshti M,von Mallek D,Mottaghy FM,Heinzel A

更新日期：2019-05-21 00:00:00

abstract：:Patients with diabetes tend to have an increased risk of osteoporosis that may be related to hyperglycemia. In vitro evidence has shown that high glucose can affect the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs). Tissue regeneration depends mainly on MSCs. However, the exact mechanis...

journal_title：EXCLI journal

authors： Wang J,Wang B,Li Y,Wang D,Lingling E,Bai Y,Liu H

更新日期：2013-06-27 00:00:00

abstract：:Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from ...

journal_title：EXCLI journal

authors： Khalighi Sikaroudi M,Mokhtare M,Shidfar F,Janani L,Faghihi Kashani A,Masoodi M,Agah S,Dehnad A,Shidfar S

更新日期：2020-05-19 00:00:00

abstract：:Previous research has shown the beneficial effects of aqueous extract of Piper sarmentosum (P.s) on atherosclerosis. The first stage in atherosclerosis is the formation of foam cell. The aim of this study was to investigate the effect of the methanol extract of P.s on fatty streaks by calculating neointimal foam cell ...

journal_title：EXCLI journal

authors： Amran AA,Zakaria Z,Othman F,Das S,Al-Mekhlafi HM,Raj S,Nordin NA

更新日期：2012-06-15 00:00:00

abstract：:L-asparaginase and L-glutaminase can be effectively used for the treatment of patients who suffer from accute lymphoblastic leukemia and tumor cells. Microbial sources are the best source for the bulk production of these enzymes. However, their long-term administration may cause immunological responses, so screening f...

journal_title：EXCLI journal

authors： Shirazian P,Asad S,Amoozegar MA

更新日期：2016-04-18 00:00:00

abstract：:A reliable biomarker has not been identified to predict the outcome of traumatic brain injury (TBI) in children. Therefore, the present systematic review and meta-analysis aimed to assess the association between neuron specific enolase (NSE) and traumatic brain injury (TBI) in children. Two independent reviewers searc...

journal_title：EXCLI journal

authors： Nakhjavan-Shahraki B,Yousefifard M,Oraii A,Sarveazad A,Hosseini M

更新日期：2017-07-03 00:00:00

abstract：:Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive con...

journal_title：EXCLI journal

authors： Gargouri M,Soussi A,Akrouti A,Magné C,El Feki A

更新日期：2018-03-02 00:00:00

abstract：:Bladder cancer (BC) is the sixth most common malignancy in men and 17th in women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study is to evaluate the clinical significance of urine exosomal PVT-1, ANRIL and PCAT-1 as a biomarker in BC patients with tumors cla...

journal_title：EXCLI journal

authors： Abbastabar M,Sarfi M,Golestani A,Karimi A,Pourmand G,Khalili E

更新日期：2020-03-04 00:00:00

abstract：:This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, including nitrous oxide, isoflurane, and sevoflurane was associated with any hepatotoxic or nephrotoxic changes. Fifty-two operating room personnel and 52 non-exposed subjects were studied. A questionnaire pe...

journal_title：EXCLI journal

authors： Neghab M,Amiri F,Soleimani E,Yousefinejad S,Hassanzadeh J

更新日期：2020-03-25 00:00:00

abstract：:Hepatocellular carcinoma or Liver cancer (LC) is the sixth most common cancer and the fourth cause of death worldwide in 2018. There has not been a comprehensive study on the survival rate of patients with LC in Asia yet. Therefore, the present study was conducted to evaluate the survival rate of patients with LC in A...

journal_title：EXCLI journal

authors： Hassanipour S,Vali M,Gaffari-Fam S,Nikbakht HA,Abdzadeh E,Joukar F,Pourshams A,Shafaghi A,Malakoutikhah M,Arab-Zozani M,Salehiniya H,Mansour-Ghanaei F

更新日期：2020-01-13 00:00:00

abstract：:Nanoencapsulation of drug/small molecules in nanocarriers (NCs) is a very promising approach for development of nanomedicine. Modern drug encapsulation methods allow efficient loading of drug molecules inside the NCs thereby reducing systemic toxicity associated with drugs. Targeting of NCs can enhance the accumulatio...

journal_title：EXCLI journal

authors： Kumari A,Singla R,Guliani A,Yadav SK

更新日期：2014-03-20 00:00:00

abstract：:Genome editing technologies include techniques used for desired genetic modifications and allow the insertion, modification or deletion of specific DNA fragments. Recent advances in genome biology offer unprecedented promise for interdisciplinary collaboration and applications in gene editing. New genome editing techn...

journal_title：EXCLI journal

authors： Görücü Yilmaz S

更新日期：2021-01-04 00:00:00

abstract：:Phoenix sylvestris (Arecaceae family) known as Indian Date Palm has been identified as a component of traditional medicine against various ailments. The present study was focused on phytochemical screening of crude hexane, dichloromethane and methanol leaf extracts. The crude extracts showed the presence of alkaloids,...

journal_title：EXCLI journal

authors： Sharma DC,Shukla R,Ali J,Sharma S,Bajpai P,Pathak N

更新日期：2016-02-05 00:00:00

abstract：:The aim of this study is to investigate the mechanism of electro-acupuncture (EA) on the recovery of injured spinal cord. Rats were randomly divided into normal control, sham-operated, SCI, SCI+EA group and T10 segment spinal cord injury (SCI) rat model was established by the modified Allen's method. After 7 days, the...

journal_title：EXCLI journal

authors： Zhu Y,Wu Y,Zhang R

更新日期：2017-03-23 00:00:00

abstract：:Spontaneous eye-blinks occur much more often than it would be necessary to maintain the tear film on the eyes. Various factors like cognitive demand, task engagement, or fatigue are influencing spontaneous blink rate. During cognitive information processing there is evidence that blinks occur preferably at moments tha...

journal_title：EXCLI journal

authors： Wascher E,Heppner H,Möckel T,Kobald SO,Getzmann S

更新日期：2015-11-27 00:00:00

abstract：:The liver is famous for its strong regenerative capacity, employing different modes of regeneration according to type and extent of injury. Mature liver cells are able to proliferate in order to replace the damaged tissue allowing the recovery of the parenchymal function. In more severe scenarios hepatocytes are belie...

journal_title：EXCLI journal

authors： Verhulst S,Best J,van Grunsven LA,Dollé L

更新日期：2015-01-06 00:00:00

abstract：:Nephropathy associated with type 2 diabetes is the single most common cause of end-stage renal disease. The aim of the present study was to evaluate the preventive effect of ethanolic extract of Embelia ribes fruit (EER) against high fat diet (HFD) and low dose streptozotocin (STZ)-induced diabetic nephrotoxicity in W...

journal_title：EXCLI journal

authors： Chaudhari HS,Bhandari U,Khanna G

更新日期：2013-09-24 00:00:00

abstract：:Objective: Although osteoarthritis (OA) is widely accepted as a degenerative disease, autoimmune processes are believed to be involved in the pathogenesis. There are limited studies in this area and most of them focused on antibodies against chondrocyte membrane. In an attempt to address the paucity of evidence in thi...

journal_title：EXCLI journal

authors： Sakthiswary R,Rajalingam S,Norazman MR,Hussein H

更新日期：2012-09-07 00:00:00

abstract：:Recently, many articles have reported different levels and distribution of amphetamine hitherto detected in biological fluids now appreciably found in aquatic environment at ng/L levels. Identification and measurement of amphetamine and its metabolites in surface and sewage waters using higher performance liquid chrom...

journal_title：EXCLI journal

authors： Mustapha AO,Ajao UL

更新日期：2011-08-19 00:00:00

abstract：:Renin Angiotensin Aldosterone System (RAAS) plays an important role in the development of hypertension. On the other hand, hypertension is a well-known and independent risk factor for cognitive impairment. The aim of the present study was to evaluate the relationship of blood pressure control, plasma angiotensin pepti...

journal_title：EXCLI journal

authors： Sen S,Gürel N,Ufuktepe B,Özünal ZG,Büyüklü Ç,Üresin Y

更新日期：2017-03-10 00:00:00

abstract：:Recently, bioinformatics has advanced to the level that it allows almost accurate prediction of molecular interactions that hold together a protein and a ligand in the bound state. For instance, the program AutoDock has been developed to provide a procedure for predicting the interaction of small molecules with macrom...

journal_title：EXCLI journal

authors： Rizvi SM,Shakil S,Haneef M

更新日期：2013-09-23 00:00:00

abstract：:From both the structural and functional points of view, β-turns play important biological roles in proteins. In the present study, a novel two-stage hybrid procedure has been developed to identify β-turns in proteins. Binary logistic regression was initially used for the first time to select significant sequence param...

journal_title：EXCLI journal

authors： Asghari MP,Hayatshahi SH,Abdolmaleki P

更新日期：2012-07-05 00:00:00

abstract：:Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic pote...

journal_title：EXCLI journal

authors： Sharif A,Akhtar MF,Akhtar B,Saleem A,Manan M,Shabbir M,Ashraf M,Peerzada S,Ahmed S,Raza M

更新日期：2017-04-24 00:00:00

abstract：:R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain. Here, curcumin, fl...

journal_title：EXCLI journal

authors： Malami I,Muhammad A,Etti IC,Waziri PM,Alhassan AM

更新日期：2017-12-08 00:00:00

abstract：:Octyl gallate (OG) is an antioxidant commonly used in food, although there is no definition of its acceptable daily intake. There are reports in vitro and in vivo showing that food additives and drugs can alter lipid metabolism. Lipid droplet accumulation in hepatic cells is one of the main findings in the unregulated...

journal_title：EXCLI journal

authors： Lima KG,Schneider Levorse VG,Rosa Garcia MC,de Souza Basso B,Pasqualotto Costa B,Antunes GL,Luft C,Haute GV,Leal Xavier L,Donadio MVF,Rodrigues de Oliveira J

更新日期：2020-07-06 00:00:00

abstract：:The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6...

journal_title：EXCLI journal

authors： Tila D,Yazdani-Arazi SN,Ghanbarzadeh S,Arami S,Pourmoazzen Z

更新日期：2015-01-06 00:00:00

abstract：:The effect of leaf essential oil of Hoslundia opposita (Vahl) on the haematological parameters of alloxan-induced diabetic rats was investigated. Forty-eight albino rats (Rattus norvegicus), of average weight 132.5 g, were randomly selected into normal and diabetic groups, each with four sub-groups. The rats were trea...

journal_title：EXCLI journal

authors： Muhammad NO,Akolade JO,Usman LA,Oloyede OB

更新日期：2012-09-25 00:00:00